Abundant DNA 6mA methylation during early embryogenesis of zebrafish and pig
Jianzhao Liu(Howard Hughes Medical Institute), Yuanxiang Zhu(Chinese Academy of Sciences), Guan‐Zheng Luo(Howard Hughes Medical Institute), Xinxia Wang(Howard Hughes Medical Institute), Yanan Yue(Howard Hughes Medical Institute), Xiaona Wang(Howard Hughes Medical Institute), Xin Zong(Zhejiang University), Kai Chen(Howard Hughes Medical Institute), Hang Yin(Howard Hughes Medical Institute), Ye Fu(Howard Hughes Medical Institute), Dali Han(Howard Hughes Medical Institute), Yizhen Wang(Zhejiang University), Dahua Chen(Chinese Academy of Sciences), Chuan He(Howard Hughes Medical Institute)
Cited by 263Open Access
Abstract
-methyldeoxyadenosine (6mA) is a well-known prokaryotic DNA modification that has been shown to exist and play epigenetic roles in eukaryotic DNA. Here we report that 6mA accumulates up to ∼0.1-0.2% of total deoxyadenosine during early embryogenesis of vertebrates, but diminishes to the background level with the progression of the embryo development. During this process a large fraction of 6mAs locate in repetitive regions of the genome.
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