Bidirectional intragraft alloreactivity drives the repopulation of human intestinal allografts and correlates with clinical outcome
Julien Zuber(Columbia University Irving Medical Center), Brittany Shonts(Columbia University Irving Medical Center), Sai Ping Lau(Columbia University Irving Medical Center), Aleksandar Obradović(Columbia University Irving Medical Center), Jianing Fu(Columbia University Irving Medical Center), Suxiao Yang(Columbia University Irving Medical Center), Marion Lambert(Inserm), Shana M. Coley(Columbia University Irving Medical Center), Joshua Weiner(Columbia University Irving Medical Center), Joseph Thome(Columbia University Irving Medical Center), Susan DeWolf(Columbia University Irving Medical Center), Donna L. Färber(Columbia University Irving Medical Center), Yufeng Shen(Columbia University Irving Medical Center), Sophie Caillat‐Zucman(Inserm), Govind Bhagat(Columbia University), Adam Griesemer(Columbia University Irving Medical Center), Mercedes Martínez(Columbia University), Tomoaki Kato(Columbia University), Megan Sykes(Columbia University Irving Medical Center)
Cited by 133Open Access
Abstract
CD8+ alpha beta T cells, marked predominance of HvG clones, and accelerated T cell turnover in the graft. Ultimately, these recipient T cells acquired a steady state tissue-resident phenotype, but regained CD28 expression during rejections. Increased ratios of GvH to HvG clones were seen in non-rejectors, potentially mitigating the constant threat of rejection posed by HvG clones persisting within the tissue-resident graft T cell population.
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