Cyclic Hydroxyamidines as Amide Isosteres: Discovery of Oxadiazolines and Oxadiazines as Potent and Highly Efficacious γ-Secretase Modulators in Vivo
Z. J. Sun, Zhaoning Zhu(Merck & Co., Inc., Rahway, NJ, USA (United States)), Xiaohong Zhu, Gioconda Gallo, Michael Czarniecki(Merck & Co., Inc., Rahway, NJ, USA (United States)), Anandan Palani, Monica Vicarel, Eric M. Parker(University of New Hampshire), Troy McCracken, Giuseppe Terracina, Amin A. Nomeir, Xianhai Huang, Hubert Josien(Merck & Co., Inc., Rahway, NJ, USA (United States)), Mary Cohen-Williams, William J. Greenlee, Qi Zhang, Robert Mazzola, Irina Kazakevich, Malcolm MacCoss, Theodros Asberom, Johannes Voigt, Lixin Song, Hongmei Li(Shenyang Aerospace University), Lili Zhang(San Francisco Foundation), Ruo Xu, Zhiqiang Zhao, Julie Lee, Duane A. Burnett, Jun Qin, Nicholas A. Jones, Mihir B. Mandal, Xiaoxiang Liu, Chad Bennett, John W. Clader, James Durkin(Merck & Co., Inc., Rahway, NJ, USA (United States)), Lynn A. Hyde(Merck & Co., Inc., Rahway, NJ, USA (United States)), Inhou Chu, Thomas Bara, David Cole(Georgetown University), Dmitri Pissarnitski
Cited by 53
Related Papers
Chronic Treatment with the γ-Secretase Inhibitor LY-411,575 Inhibits β-Amyloid Peptide Production and Alters Lymphopoiesis and Intestinal Cell Differentiation
|Journal of Biological Chemistry|2004|716
The BACE1 inhibitor verubecestat (MK-8931) reduces CNS β-amyloid in animal models and in Alzheimer’s disease patients
|Science Translational Medicine|2016|416
A Green Chemistry Approach to Asymmetric Catalysis: Solvent-Free and Highly Concentrated Reactions
|Chemical Reviews|2007|353
MLi-2, a Potent, Selective, and Centrally Active Compound for Exploring the Therapeutic Potential and Safety of LRRK2 Kinase Inhibition
|Journal of Pharmacology and Experimental Therapeutics|2015|336
Reconstitutively active G protein-coupled receptors purified from baculovirus-infected insect cells.
|Journal of Biological Chemistry|1991|283