MLi-2, a Potent, Selective, and Centrally Active Compound for Exploring the Therapeutic Potential and Safety of LRRK2 Kinase Inhibition
Matthew Fell(Merck & Co., Inc., Rahway, NJ, USA (United States)), John A. Morrow(Merck & Co., Inc., Rahway, NJ, USA (United States)), Duane E. DeMong(Merck & Co., Inc., Rahway, NJ, USA (United States)), Eric M. Parker(University of New Hampshire), Michael A. Miller(University of Alabama at Birmingham), Matthew Kennedy(Merck & Co., Inc., Rahway, NJ, USA (United States)), Christian Mirescu(Merck & Co., Inc., Rahway, NJ, USA (United States)), Zhizhang Yin(Merck & Co., Inc., Rahway, NJ, USA (United States)), Jack D. Scott(Merck & Co., Inc., Rahway, NJ, USA (United States)), Kallol Basu(Merck & Co., Inc., Rahway, NJ, USA (United States)), Xiaoping Zhou, Yinghui Lin(Merck & Co., Inc., Rahway, NJ, USA (United States)), Hong Mei(Merck & Co., Inc., Rahway, NJ, USA (United States)), Carrie G. Markgraf(Merck & Co., Inc., Rahway, NJ, USA (United States)), J. Michael Ellis(Bristol-Myers Squibb (United States)), Lynn A. Hyde(Merck & Co., Inc., Rahway, NJ, USA (United States)), Boonlert Cheewatrakoolpong(Merck & Co., Inc., Rahway, NJ, USA (United States)), Frederique M. Poulet, Michelle Smith(Merck & Co., Inc., Rahway, NJ, USA (United States))
Cited by 336
Related Papers
Chronic Treatment with the γ-Secretase Inhibitor LY-411,575 Inhibits β-Amyloid Peptide Production and Alters Lymphopoiesis and Intestinal Cell Differentiation
|Journal of Biological Chemistry|2004|716
The BACE1 inhibitor verubecestat (MK-8931) reduces CNS β-amyloid in animal models and in Alzheimer’s disease patients
|Science Translational Medicine|2016|416
Reconstitutively active G protein-coupled receptors purified from baculovirus-infected insect cells.
|Journal of Biological Chemistry|1991|283
Epigenetic PTEN Silencing in Malignant Melanomas without PTEN Mutation
|American Journal Of Pathology|2000|273
Chimeric muscarinic cholinergic: beta-adrenergic receptors that activate Gs in response to muscarinic agonists.
|Journal of Biological Chemistry|1990|230