Structural Basis of Duplex Thermodynamic Stability and Enhanced Nuclease Resistance of 5′-<i>C</i>-Methyl Pyrimidine-Modified Oligonucleotides
Alexander V. Kel’in(Alnylam Pharmaceuticals (United States)), Muthiah Manoharan(Alnylam Pharmaceuticals (United States)), Muthusamy Jayaraman(Forma Therapeutics (United States)), Nate Taneja(Alnylam Pharmaceuticals (United States)), Saeed I. Khan(University of California, Los Angeles), Martin A. Maier(Alnylam Pharmaceuticals (United States)), Rajar M. Manoharan(Alnylam Pharmaceuticals (United States)), Ivan Zlatev(Alnylam Pharmaceuticals (United States)), Kallanthottathil G. Rajeev(Alnylam Pharmaceuticals (United States)), Martin Egli(Vanderbilt University), Jonathan O′Shea(Alnylam Pharmaceuticals (United States)), Anna Bisbe(Alnylam Pharmaceuticals (United States)), Klaus Charissé(Alnylam Pharmaceuticals (United States)), Joel M. Harp(Vanderbilt University)
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