New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk
Yingchang Lu(Child Health and Development Institute), Felix R. Day(University of Cambridge), Stefan Gustafsson(Uppsala University), Martin L. Buchkovich(University of North Carolina at Chapel Hill), Jianbo Na(Icahn School of Medicine at Mount Sinai), Véronique Bataille(King's College London), Diana L. Cousminer(University of Helsinki), Zari Dastani(Jewish General Hospital), Alexander Drong(Centre for Human Genetics), Tõnu Esko(Broad Institute), David M. Evans(Translational Research Institute), Mario Falchi(King's College London), Mary F. Feitosa(Washington University in St. Louis), Teresa Ferreira(Centre for Human Genetics), Åsa K. Hedman(Uppsala University), Robin Haring(Universitätsmedizin Greifswald), Pirro G. Hysi(King's College London), Mark M. Iles(University of Leeds), Anne E. Justice(University of North Carolina at Chapel Hill), Stavroula Kanoni(Queen Mary University of London), Vasiliki Lagou(Centre for Human Genetics), Rui Li(Jewish General Hospital), Xin Li(Harvard University), Adam E. Locke(University of Michigan), Lu Chen(Boston University), Reedik Mägi(Centre for Human Genetics), John R. B. Perry(University of Cambridge), Tune H. Pers(Statens Serum Institut), Qibin Qi(Albert Einstein College of Medicine), Marianna Sanna(King's College London), Ellen M. Schmidt(University of Michigan), William R. Scott(Ealing Hospital), Dmitry Shungin(Lund University), Alexander Teumer(Universitätsmedizin Greifswald), Anna A. E. Vinkhuyzen(The University of Queensland), Ryan W. Walker(Child Health and Development Institute), Harm-Jan Westra(Broad Institute), Mingfeng Zhang(Brigham and Women's Hospital), Weihua Zhang(Ealing Hospital), Wei Zhao(University of Cambridge), Zhihong Zhu(The University of Queensland), Uzma Afzal(Ealing Hospital), Tarunveer S. Ahluwalia(University of Copenhagen), Stephan J. L. Bakker(University Medical Center Groningen), Claire Bellis(Texas Biomedical Research Institute), Amélie Bonnefond(Centre National de la Recherche Scientifique), Katja Borodulin(Finnish Institute for Health and Welfare), Aron S. Buchman(Rush University Medical Center), Tommy Cederholm(Uppsala University), Audrey C. Choh(Wright State University), Hyung Jin Choi(Seoul National University), Joanne E. Curran(The University of Texas Rio Grande Valley), C.P.G.M. de Groot(Wageningen University & Research), Philip L. De Jager(Broad Institute), R.A.M. Dhonukshe-Rutten(Wageningen University & Research), Anke W. Enneman(Erasmus MC), Elodie Eury(Centre National de la Recherche Scientifique), Daniel S. Evans(Translational Research Institute), Tom Forsén(University of Helsinki), Nele Friedrich(Universitätsmedizin Greifswald), Frédéric Fumeron(Délégation Paris 5), Melissa E. Garcia(National Institute on Aging), Simone Gärtner(Universitätsmedizin Greifswald), Bok‐Ghee Han(Korea National Institute of Health), Aki S. Havulinna(Finnish Institute for Health and Welfare), Caroline Hayward(Institute of Genetics and Cancer), Dena Hernández(National Institutes of Health), Hans L. Hillege(University Medical Center Groningen), Till Ittermann(Universitätsmedizin Greifswald), Jack W. Kent(Texas Biomedical Research Institute), Ivana Kolčić(University of Split), Tiina Laatikainen(University of Eastern Finland), Jari Lahti(University of Helsinki), Irene Mateo Leach(University Medical Center Groningen), Christine G. Lee(Oregon Health & Science University), Jong‐Young Lee(Korea National Institute of Health), Tian Liu(Max Planck Institute for Human Development), Youfang Liu(University of North Carolina at Chapel Hill), Stéphane Lobbens(Centre National de la Recherche Scientifique), Marie Loh(Agency for Science, Technology and Research), Leo‐Pekka Lyytikäinen(Tampere University), Carolina Medina‐Gómez(Erasmus MC), Karl Michaëlsson(Uppsala University), Mike A. Nalls(National Institutes of Health), Carrie M. Nielson(Oregon Health & Science University), Laticia Oozageer(Ealing Hospital), Laura Pascoe(Newcastle University), Lavinia Paternoster(University of Bristol), Ozren Polašek(Centre for Global Health Research), Samuli Ripatti(University of Helsinki), Mark A. Sarzynski(Pennington Biomedical Research Center), Chan Soo Shin(Seoul National University), Nina Smolej Narančić(Institute for Anthropological Research), Dominik Spira(British Geriatrics Society), Priya Srikanth(Oregon Health & Science University), Elisabeth Steinhagen–Thiessen(British Geriatrics Society), Yun Ju Sung(Washington University in St. Louis), Karin M. A. Swart(Amsterdam Public Health), Leena Taittonen(Vaasa Central Hospital), Toshiko Tanaka(National Institute on Aging), Emmi Tikkanen(University of Helsinki), Nathalie van der Velde(Erasmus MC), Natasja M. van Schoor(Amsterdam Public Health), Niek Verweij(University Medical Center Groningen), Alan F. Wright(Institute of Genetics and Cancer), Lei Yu(Rush University Medical Center), Joseph M. Zmuda(University of Pittsburgh), Niina Eklund(Finnish Institute for Health and Welfare), Terrence Forrester(University of the West Indies System), Niels Grarup(University of Copenhagen), Anne Jackson(University of Michigan), Kati Kristiansson(University of Helsinki), Teemu Kuulasmaa(University of Eastern Finland), Johanna Kuusisto(University of Eastern Finland), Peter Lichtner(Helmholtz Zentrum München), Jian’an Luan(University of Cambridge), Anubha Mahajan(Centre for Human Genetics), Satu Männistö(Finnish Institute for Health and Welfare), Cameron D. Palmer(Broad Institute), Janina S. Ried(Helmholtz Zentrum München), Robert A. Scott(University of Cambridge), Alena Stančáková(University of Eastern Finland), Peter J. Wagner(University of Helsinki), Ayşe Demirkan(Erasmus MC), Angela Döring(Helmholtz Zentrum München), Vilmundur Guðnason(University of Iceland), Douglas P. Kiel(Beth Israel Deaconess Medical Center), Brigitte Kühnel(Helmholtz Zentrum München), Massimo Mangino(King's College London), Barbara McKnight(University of Washington), Cristina Menni(King's College London), Jeffrey R. O’Connell(University of Maryland, Baltimore), Ben A. Oostra(Erasmus MC), Alan R. Shuldiner(University of Maryland, Baltimore), Kijoung Song(GlaxoSmithKline (United States)), Liesbeth Vandenput(University of Gothenburg), Cornelia M. van Duijn(Erasmus MC), Péter Vollenweider(University of Lausanne), Charles C. White(Boston University), Michael Boehnke(University of Michigan), Yvonne Boettcher(IFB Adiposity Diseases), Richard S. Cooper(Loyola University Chicago), Nita G. Forouhi(University of Cambridge), Christian Gieger(Helmholtz Zentrum München), Harald Grallert(Helmholtz Zentrum München), Aroon D. Hingorani(University College London), Torben Jørgensen(University of Copenhagen), Pekka Jousilahti(Finnish Institute for Health and Welfare), Mika Kivimäki(University College London), Meena Kumari(University College London), Markku Laakso(University of Eastern Finland), Claudia Langenberg(University of Cambridge), Allan Linneberg(Glostrup Hospital), Amy Luke(Loyola University Chicago), Colin A. McKenzie(University of the West Indies System), Aarno Palotie(Wellcome Sanger Institute), Oluf Pedersen(University of Copenhagen), Annette Peters(Helmholtz Zentrum München), Konstantin Strauch(Helmholtz Zentrum München), Bamidele O. Tayo(Loyola University Chicago), Nicholas J. Wareham(University of Cambridge), David A. Bennett(Rush University Medical Center), Lars Bertram(Institute for Integrative and Experimental Genomics), John Blangero(The University of Texas Rio Grande Valley), Matthias Blüher(IFB Adiposity Diseases), Claude Bouchard(Pennington Biomedical Research Center), Harry Campbell(Centre for Global Health Research), Nam H. Cho(Ajou University), Steven R. Cummings(California Pacific Medical Center), Stefan A. Czerwinski(Wright State University), Ilja Demuth(British Geriatrics Society), Rahel Eckardt(British Geriatrics Society), Johan G. Eriksson(University of Helsinki), Luigi Ferrucci(National Institute on Aging), Oscar H. Franco(Erasmus MC), Philippe Froguel(Centre National de la Recherche Scientifique), Ron T. Gansevoort(University Medical Center Groningen), Torben Hansen(University of Copenhagen), Tamara B. Harris(National Institute on Aging), Nicholas D. Hastie(Institute of Genetics and Cancer), Markku Heliövaara(Finnish Institute for Health and Welfare), Albert Hofman(Erasmus MC), Joanne M. Jordan(University of North Carolina at Chapel Hill), Antti Jula(Finnish Institute for Health and Welfare), Mika Kähönen(Tampere University Hospital), Eero Kajantie(University of Helsinki), Paul Knekt(Finnish Institute for Health and Welfare), Seppo Koskinen(Finnish Institute for Health and Welfare), Péter Kovács(IFB Adiposity Diseases), Terho Lehtimäki(Tampere University), Lars Lind(Uppsala University), Ching‐Ti Liu(University of North Carolina at Chapel Hill), Eric Orwoll(Oregon Health & Science University), Clive Osmond(Southampton General Hospital), Markus Perola(Finnish Institute for Health and Welfare), Louis Përusse(Université Laval), Olli T. Raitakari(University of Turku), Tuomo Rankinen(Pennington Biomedical Research Center), D. C. Rao(Washington University in St. Louis), Treva Rice(Washington University in St. Louis), Fernando Rivadeneira(Erasmus MC), Igor Rudan(Centre for Global Health Research), Veikko Salomaa(Finnish Institute for Health and Welfare), Thorkild I. A. Sørensen(Novo Nordisk Foundation), Michael Stümvoll(IFB Adiposity Diseases), Anke Tönjes(Leipzig University), Bradford Towne(Wright State University), Gregory J. Tranah(California Pacific Medical Center), Angelo Tremblay(Université Laval), André G. Uitterlinden(Erasmus MC), Pim van der Harst(University Medical Center Groningen), Erkki Vartiainen(Finnish Institute for Health and Welfare), Jorma SA Viikari(University of Turku), Véronique Vitart(Institute of Genetics and Cancer), Marie‐Claude Vohl(Université Laval), Henry Völzke(Universitätsmedizin Greifswald), Mark Walker(Broad Institute), Henri Wallaschofski(Universitätsmedizin Greifswald), Sarah H. Wild(University of Edinburgh), James F. Wilson(Centre for Global Health Research), Loïc Yengo(Centre National de la Recherche Scientifique), D. Timothy Bishop(University of Leeds), Ingrid B. Borecki(Regeneron (United States)), John C. Chambers(Imperial College Healthcare NHS Trust), L. Adrienne Cupples(Boston University), Abbas Dehghan(Erasmus MC), Panos Deloukas(Queen Mary University of London), Ghazaleh Fatemifar(University of Bristol), Caroline S. Fox(Harvard University), Terrence S. Furey(University of North Carolina at Chapel Hill), Lude Franke(University Medical Center Groningen), Jiali Han(Indiana University Health), David J. Hunter(Broad Institute), Juha Karjalainen(University Medical Center Groningen), Fredrik Karpe(Churchill Hospital), Robert C. Kaplan(Albert Einstein College of Medicine), Jaspal S. Kooner(Imperial College Healthcare NHS Trust), Mark I. McCarthy(Centre for Human Genetics), Joanne M. Murabito(Boston University), Andrew P. Morris(Centre for Human Genetics), Julia Newton‐Bishop(University of Leeds), Kari E. North(University of North Carolina at Chapel Hill), Claes Ohlsson(University of Gothenburg), Ken K. Ong(University of Cambridge), Inga Prokopenko(Centre for Human Genetics), J. Brent Richards(King's College London), Eric E. Schadt(Icahn School of Medicine at Mount Sinai), Tim D. Spector(King's College London), Elisabeth Widén(University of Helsinki), Cristen J. Willer(University of Michigan), Jian Yang(The University of Queensland), Erik Ingelsson(Uppsala University), Karen L. Mohlke(University of North Carolina at Chapel Hill), Joel N. Hirschhorn(Broad Institute), J. Andrew Pospisilik(Max Planck Institute of Immunobiology and Epigenetics), M. Carola Zillikens(Erasmus MC), Cecilia M. Lindgren(Broad Institute), Tuomas O. Kilpeläinen(University of Copenhagen), Ruth J. F. Loos(Child Health and Development Institute)
Cited by 316Open Access
Abstract
To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (P<5 × 10(-8)), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and lean mass. In particular, the loci more strongly associated with BF% showed distinct cross-phenotype association signatures with a range of cardiometabolic traits revealing new insights in the link between adiposity and disease risk.
Related Papers
No related papers found
Powered by citation graph analysis