Unique features of a global human ectoparasite identified through sequencing of the bed bug genome

Joshua B. Benoit(University of Cincinnati), Zach N. Adelman(Virginia Tech), Klaus Reinhardt(Technische Universität Dresden), Amanda Dolan(University of Rochester), Monica F. Poelchau(National Agricultural Library), Emily C. Jennings(University of Cincinnati), Elise M. Szuter(University of Cincinnati), Richard Hagan(University of Cincinnati), Hemant Gujar(University of Kentucky), Jayendra Nath Shukla(University of Kentucky), Fang Zhu(University of Kentucky), M. Mohan(Indian Council of Agricultural Research), David R. Nelson(University of Tennessee Health Science Center), Andrew J. Rosendale(University of Cincinnati), Christian Derst(University of Cologne), Valentina Resnik(Goethe University Frankfurt), Sebastian Wernig(Goethe University Frankfurt), Pamela Menegazzi(University of Würzburg), Christian Wegener(University of Würzburg), Nicolai Peschel(University of Würzburg), Jacob M. Hendershot(University of Cincinnati), Wolfgang Blenau(University of Cologne), Reinhard Predel(University of Cologne), Paul R. Johnston(Freie Universität Berlin), Panagiotis Ioannidis(University of Geneva), Robert M. Waterhouse(Broad Institute), Ralf Nauen(Bayer (Germany)), Corinna Schorn(Bayer (Germany)), Mark‐Christoph Ott(Bayer (Germany)), Frank Maiwald(Bayer (Germany)), J. Spencer Johnston(Texas A&M University), Ameya D. Gondhalekar(Purdue University West Lafayette), Michael E. Scharf(Purdue University West Lafayette), Brittany F. Peterson(Purdue University West Lafayette), Kapil R. Raje(Purdue University West Lafayette), Benjamin A. Hottel(University of Florida), David Armisén(École Normale Supérieure de Lyon), Antonin Crumière(École Normale Supérieure de Lyon), Peter Refki(École Normale Supérieure de Lyon), M. Emília Santos(École Normale Supérieure de Lyon), Essia Sghaier(École Normale Supérieure de Lyon), Séverine Viala(École Normale Supérieure de Lyon), Abderrahman Khila(École Normale Supérieure de Lyon), Seung‐Joon Ahn(Max Planck Institute for Chemical Ecology), Christopher Childers(National Agricultural Library), Chien‐Yueh Lee(National Taiwan University), Han Lin(National Taiwan University), Daniel Hughes(Baylor College of Medicine), Elizabeth J. Duncan(University of Otago), Shwetha C. Murali(Baylor College of Medicine), Jiaxin Qu(Baylor College of Medicine), Shannon Dugan(Baylor College of Medicine), Sandra L. Lee(Baylor College of Medicine), Hsu Chao(Baylor College of Medicine), Huyen Dinh(Baylor College of Medicine), Yi Han(Baylor College of Medicine), HarshaVardhan Doddapaneni(Baylor College of Medicine), Kim C. Worley(Baylor College of Medicine), Donna M. Muzny(Baylor College of Medicine), David A. Wheeler(Massey University), Kristen A. Panfilio(University of Cologne), Iris M. Vargas Jentzsch(University of Cologne), Edward L. Vargo(Texas A&M University), Warren Booth(University of Tulsa), Markus Friedrich(Wayne State University), Matthew T. Weirauch(Cincinnati Children's Hospital Medical Center), Michelle A. E. Anderson(Virginia Tech), Jeffery W. Jones(Wayne State University), Omprakash Mittapalli(The Ohio State University), Chaoyang Zhao(The Ohio State University), Jing‐Jiang Zhou(Rothamsted Research), Jay D. Evans(Agricultural Research Service), Geoffrey M. Attardo(Yale University), Hugh M. Robertson(University of Illinois Urbana-Champaign), Evgeny M. Zdobnov(University of Geneva), José M. C. Ribeiro(National Institute of Allergy and Infectious Diseases), Richard A. Gibbs(Baylor College of Medicine), John H. Werren(University of Rochester), Subba Reddy Palli(University of Kentucky), Coby Schal(North Carolina State University), Stephen Richards(Baylor College of Medicine)
Nature Communications
February 2, 2016
10.1038/ncomms10165
Cited by 227Open Access
Full Text

Abstract

The bed bug, Cimex lectularius, has re-established itself as a ubiquitous human ectoparasite throughout much of the world during the past two decades. This global resurgence is likely linked to increased international travel and commerce in addition to widespread insecticide resistance. Analyses of the C. lectularius sequenced genome (650 Mb) and 14,220 predicted protein-coding genes provide a comprehensive representation of genes that are linked to traumatic insemination, a reduced chemosensory repertoire of genes related to obligate hematophagy, host-symbiont interactions, and several mechanisms of insecticide resistance. In addition, we document the presence of multiple putative lateral gene transfer events. Genome sequencing and annotation establish a solid foundation for future research on mechanisms of insecticide resistance, human-bed bug and symbiont-bed bug associations, and unique features of bed bug biology that contribute to the unprecedented success of C. lectularius as a human ectoparasite.

Related Papers

No related papers found

Powered by citation graph analysis