Discovery of Pyrophosphate Diesters as Tunable, Soluble, and Bioorthogonal Linkers for Site-Specific Antibody–Drug Conjugates
Jeffrey C. Kern, R. M. Garbaccio(Merck & Co., Inc., Rahway, NJ, USA (United States)), Mark T. Cancilla, Rena Zhang, Anthony Palmieri, Prasanthi Geda, Peter Stivers, Andrew Beck(Beth Israel Deaconess Medical Center), Isabel Figueroa(Merck & Co., Inc., Rahway, NJ, USA (United States)), Nick Knudsen(Ambrx (United States)), Jeffrey Zhang(Merck & Co., Inc., Rahway, NJ, USA (United States)), Mangeng Cheng, Kristen Kwasnjuk, Anthony Manibusan(Ambrx (United States)), Daniela M. Tomazela(Merck & Co., Inc., Rahway, NJ, USA (United States)), Juhi Firdos(Ambrx (United States)), Peter G. Schultz(Scripps Research Institute), Damien Bresson(Ambrx (United States)), Maribel Beaumont(Merck & Co., Inc., Rahway, NJ, USA (United States)), Guo Feng, Linda Liang(Merck & Co., Inc., Rahway, NJ, USA (United States)), SuChun Hsieh(Merck & Co., Inc., Rahway, NJ, USA (United States)), Ying Sun(Wuhan University), Dennis Gately(Ambrx (United States)), Philip E. Brandish, Sanjiv Shah, Deborah Dooney
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