Draft Genome Sequence of the Sexually Transmitted Pathogen <i>Trichomonas vaginalis</i>
Jane M. Carlton(Human Genome Sciences (United States)), Robert P. Hirt(Human Genome Sciences (United States)), Joana C. Silva(Human Genome Sciences (United States)), Arthur L. Delcher(Human Genome Sciences (United States)), Michael C. Schatz(Human Genome Sciences (United States)), Qi Zhao(Human Genome Sciences (United States)), Jennifer R. Wortman(Human Genome Sciences (United States)), Shelby Bidwell(Human Genome Sciences (United States)), U. Cecilia M. Alsmark(Human Genome Sciences (United States)), Sébastien Besteiro(Human Genome Sciences (United States)), Thomas Sicheritz‐Pontén(Human Genome Sciences (United States)), Christophe Noël(Human Genome Sciences (United States)), Joel B. Dacks(Human Genome Sciences (United States)), Peter G. Foster(Human Genome Sciences (United States)), Cédric Simillion(Human Genome Sciences (United States)), Yves Van de Peer(Human Genome Sciences (United States)), Diego Miranda‐Saavedra(Human Genome Sciences (United States)), Geoffrey J. Barton(Human Genome Sciences (United States)), Gareth D. Westrop(Human Genome Sciences (United States)), Sylke Müller(Human Genome Sciences (United States)), Daniele Dessì(Human Genome Sciences (United States)), Pier Luigi Fiori(Human Genome Sciences (United States)), Qinghu Ren(Human Genome Sciences (United States)), Ian T. Paulsen(Human Genome Sciences (United States)), Hanbang Zhang(Human Genome Sciences (United States)), Felix Bastida(Human Genome Sciences (United States)), Augusto Simões-Barbosa(Human Genome Sciences (United States)), Mark T. Brown(Human Genome Sciences (United States)), Richard D. Hayes(Human Genome Sciences (United States)), Mandira Mukherjee(Human Genome Sciences (United States)), Cheryl Okumura(Human Genome Sciences (United States)), Rachel Schneider(Human Genome Sciences (United States)), Alias Smith(Human Genome Sciences (United States)), Stepanka Vanacova(Human Genome Sciences (United States)), Maria Villalvazo(Human Genome Sciences (United States)), Brian J. Haas(Human Genome Sciences (United States)), Mihaela Pertea(Human Genome Sciences (United States)), Tamara V. Feldblyum(Human Genome Sciences (United States)), Terry Utterback(Human Genome Sciences (United States)), Chung-Li Shu(Human Genome Sciences (United States)), Kazutoyo Osoegawa(Human Genome Sciences (United States)), Pieter J. de Jong(Human Genome Sciences (United States)), Ivan Hrdý(Human Genome Sciences (United States)), Lenka Horváthová(Human Genome Sciences (United States)), Zuzana Zubáčová(Human Genome Sciences (United States)), Pavel Doležal(Human Genome Sciences (United States)), Shehre-Banoo Malik(Human Genome Sciences (United States)), John M. Logsdon(Human Genome Sciences (United States)), Katrin Henze(Human Genome Sciences (United States)), Arti Gupta(Human Genome Sciences (United States)), Ching C. Wang(Human Genome Sciences (United States)), Rebecca Dunne(Human Genome Sciences (United States)), Jacqueline Upcroft(Human Genome Sciences (United States)), Peter Upcroft(Human Genome Sciences (United States)), Owen White(Human Genome Sciences (United States)), Steven L. Salzberg(Human Genome Sciences (United States)), Petrus Tang(Human Genome Sciences (United States)), Cheng‐Hsun Chiu(Human Genome Sciences (United States)), Ying‐Shiung Lee(Human Genome Sciences (United States)), T. Martin Embley(Human Genome Sciences (United States)), Graham H. Coombs(Human Genome Sciences (United States)), Jeremy C. Mottram(Human Genome Sciences (United States)), Jan Tachezy(Human Genome Sciences (United States)), Claire M. Fraser(Human Genome Sciences (United States)), Patricia J. Johnson(Human Genome Sciences (United States))
Cited by 840Open Access
Abstract
We describe the genome sequence of the protist Trichomonas vaginalis, a sexually transmitted human pathogen. Repeats and transposable elements comprise about two-thirds of the approximately 160-megabase genome, reflecting a recent massive expansion of genetic material. This expansion, in conjunction with the shaping of metabolic pathways that likely transpired through lateral gene transfer from bacteria, and amplification of specific gene families implicated in pathogenesis and phagocytosis of host proteins may exemplify adaptations of the parasite during its transition to a urogenital environment. The genome sequence predicts previously unknown functions for the hydrogenosome, which support a common evolutionary origin of this unusual organelle with mitochondria.
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