Life with 6000 Genes
A. Goffeau(UCLouvain), B. G. Barrell(Wellcome Sanger Institute), Howard Bussey(McGill University), Ronald W. Davis(Stanford University), Bernard Dujon(Centre National de la Recherche Scientifique), Horst Feldmann(Technical University of Munich), Francis Galibert(Centre National de la Recherche Scientifique), Jörg D. Hoheisel(DKFZ-ZMBH Alliance), Claude Jacq(Centre National de la Recherche Scientifique), Mark Johnston(Washington University in St. Louis), Edward J. Louis(John Radcliffe Hospital), Hans‐Werner Mewes(Max Planck Institute of Biochemistry), Yasufumi Murakami(University of Tsukuba), Peter Philippsen(University of Basel), Hervé Tettelin(UCLouvain), Stephen G. Oliver(University of Manchester)
Cited by 4,256
Abstract
The genome of the yeast Saccharomyces cerevisiae has been completely sequenced through a worldwide collaboration. The sequence of 12,068 kilobases defines 5885 potential protein-encoding genes, approximately 140 genes specifying ribosomal RNA, 40 genes for small nuclear RNA molecules, and 275 transfer RNA genes. In addition, the complete sequence provides information about the higher order organization of yeast's 16 chromosomes and allows some insight into their evolutionary history. The genome shows a considerable amount of apparent genetic redundancy, and one of the major problems to be tackled during the next stage of the yeast genome project is to elucidate the biological functions of all of these genes.