Stability of the Latent Reservoir for HIV‐1 in Patients Receiving Valproic Acid
Janet D. Siliciano(Johns Hopkins University), Jun Lai(Johns Hopkins University), Marc Callender(Johns Hopkins University), Eleanor Pitt(Johns Hopkins University), Hao Zhang(Johns Hopkins University), Joseph B. Margolick(Johns Hopkins University), Joel E. Gallant(Johns Hopkins Medicine), Joseph Cofrancesco(Johns Hopkins University), Richard D. Moore(Johns Hopkins Medicine), Stephen J. Gange(Johns Hopkins University), Robert F. Siliciano(Johns Hopkins University)
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Abstract
In light of a recent report that short-term treatment with valproic acid (VA) might accelerate the decay of the latent reservoir for HIV-1 in patients receiving combination therapy and allow eventual eradication of the infection, we studied patients with prolonged suppression of viremia who were receiving combination therapy and who had also been receiving chronic VA therapy for neurological or psychiatric conditions. Latently infected cells were readily detected in all patients at levels comparable to those seen in patients receiving combination therapy alone. We conclude that the clinical use of VA has no ancillary effect on the decay of the latent reservoir.
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