Designer emulsions using microfluidics
Rhutesh K. Shah(Harvard University), Ho Cheung Shum(Harvard University), Amy C. Rowat(Harvard University), Daeyeon Lee(Harvard University), Jeremy J. Agresti(Harvard University), Andrew S. Utada(Harvard University), Liang‐Yin Chu(Sichuan University), Jin Woong Kim(Harvard University), Alberto Fernández‐Nieves(Georgia Institute of Technology), Carlos J. Martinez(Harvard University), David A. Weitz(Harvard University)
Cited by 754Open Access
Abstract
We describe new developments for the controlled fabrication of monodisperse emulsions using microfluidics. We use glass capillary devices to generate single, double, and higher order emulsions with exceptional precision. These emulsions can serve as ideal templates for generating well-defined particles and functional vesicles. Polydimethylsiloxane microfluidic devices are also used to generate picoliter-scale water-in-oil emulsions at rates as high as 10 000 drops per second. These emulsions have great potential as individual microvessels in high-throughput screening applications, where each drop serves to encapsulate single cells, genes, or reactants.
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