A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation carriers and is associated with hormone receptor–negative breast cancer in the general population

EMBRACE; Antonis C. Antoniou; GEMO Study Collaborators; HEBON; kConFab; SWE-BRCA; MOD SQUAD; GENICA; Xianshu Wang; Zachary S. Fredericksen; Lesley McGuffog; Robert F. Tarrell; Olga M. Sinilnikova; Sue Healey; Jonathan J. Morrison; Christiana Kartsonaki; Timothy G. Lesnick; Maya Ghoussaini; Daniel Barrowdale; Susan Peock; Margaret Cook; Clare Oliver; Debra Frost; Diana Eccles; D. Gareth Evans; Rosalind A. Eeles; Louise Izatt; Carol Chu; Fiona Douglas; J. Paterson; Dominique Stoppa-Lyonnet; Claude Houdayer; Sylvie Mazoyer; Sophie Giraud; Christine Lasset; Audrey Remenieras; Olivier Caron; Agnès Hardouin; Pascaline Berthet; Frans B.L. Hogervorst; Matti A. Rookus; Agnes Jager; Ans van den Ouweland; Nicoline Hoogerbrugge; Rob B. van der Luijt; Hanne Meijers‐Heijboer; E. Gómez; Peter Devilee; Maaike P.G. Vreeswijk; Jan Lubiński; Anna Jakubowska; Jacek Gronwald; Tomasz Huzarski; Tomasz Byrski; Bohdan Górski; Cezary Cybulski; Amanda B. Spurdle; Helene Holland; David E Goldgar; Esther M. John; John L. Hopper; Melissa C. Southey; Saundra S. Buys; Mary B. Daly; Mary Beth Terry; Rita K. Schmutzler; Barbara Wappenschmidt; Christoph Engel; Alfons Meindl; Sabine Preisler‐Adams; Norbert Arnold; Dieter Niederacher; Christian Sutter; Susan M. Domchek; Katherine L. Nathanson; Timothy R. Rebbeck; Joanne L. Blum; Marion Piedmonte; Gustavo C. Rodriguez; Katie Wakeley; John F. Boggess; Jack Basil; Stephanie V. Blank; Eitan Friedman; Bella Kaufman; Yael Laitman; Roni Milgrom; Irene L. Andrulis; Gord Glendon; Hilmi Özçelik; Tomas Kirchhoff; Joseph Vijai; Mia M. Gaudet; David Altshuler; Candace Guiducci; Niklas Loman; Katja Harbst; Johanna Rantala; Hans Ehrencrona; Anne‐Marie Gerdes; Mads Thomassen; Lone Sunde; Paolo Peterlongo; Siranoush Manoukian; Bernardo Bonanni; Alessandra Viel; Paolo Radice; Trinidad Caldés; Miguel de la Hoya; Christian F. Singer; Anneliese Fink-Retter; Mark H. Greene; Phuong L Mai; Jennifer T. Loud; Lucia Guidugli; Noralane M. Lindor; Thomas van Overeem Hansen; Finn C. Nielsen; Ignacio Blanco; Conxi Lázaro; Judy Garber; Susan J. Ramus; Simon A. Gayther; Catherine Phelan; Stephen Narod; Csilla I. Szabo; Javier Benítez; Ana Osório; Heli Nevanlinna; Tuomas Heikkinen; Maria A. Caligo; Mary Beattie; Ute Hamann; Andrew K Godwin; Marco Montagna; Cinzia Casella; Susan L. Neuhausen; Beth Y Karlan; Nadine Tung; Amanda Ewart Toland; Jeffrey N. Weitzel; O. I. Olopade; Jacques Simard; Penny Soucy; Wendy S. Rubinstein; Aðalgeir Arason; Gad Rennert; Nicholas G. Martin; Grant W. Montgomery; Jenny Chang‐Claude; Dieter Flesch-Janys; Hiltrud Brauch; Gianluca Severi; Laura Baglietto; Angela Cox; Simon S. Cross; Penelope Miron; Sue Gerty; William Tapper; Drakoulis Yannoukakos; George Fountzilas; Peter A Fasching; Matthias W Beckmann; Isabel dos‐Santos‐Silva; Julian Peto; Diether Lambrechts; R. Paridaens; Thomas Rüdiger; Asta Försti; Robert Winqvist; Katri Pylkäs; Robert B. Diasio; Adam M. Lee; Jeanette E. Eckel‐Passow; Celine M. Vachon; Fiona M. Blows; Kristy Driver; Alison M. Dunning; Paul D.P. Pharoah; Kenneth Offit; V. Shane Pankratz; Hakon Hakonarson; Georgia Chenevix‐Trench; Douglas F. Easton; Fergus J. Couch

doi:10.1038/ng.669

A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation carriers and is associated with hormone receptor–negative breast cancer in the general population

EMBRACE(University of Cambridge), Antonis C. Antoniou(Mayo Clinic), GEMO Study Collaborators(Mayo Clinic in Florida), HEBON(University of Cambridge), kConFab(Mayo Clinic in Florida), SWE-BRCA(Centre Léon Bérard), MOD SQUAD(QIMR Berghofer Medical Research Institute), GENICA(University of Cambridge), Xianshu Wang(Mayo Clinic), Zachary S. Fredericksen(Mayo Clinic in Florida), Lesley McGuffog(QIMR Berghofer Medical Research Institute), Robert F. Tarrell(University of Cambridge), Olga M. Sinilnikova(Centre National de la Recherche Scientifique), Sue Healey(QIMR Berghofer Medical Research Institute), Jonathan J. Morrison(University of Cambridge), Christiana Kartsonaki(University of Cambridge), Timothy G. Lesnick(Princess Anne Hospital), Maya Ghoussaini(National Health Service), Daniel Barrowdale(Royal Marsden NHS Foundation Trust), Susan Peock(Guy's and St Thomas' NHS Foundation Trust), Margaret Cook(University of Cambridge), Clare Oliver(University of Cambridge), Debra Frost(University of Cambridge), Diana Eccles(Inserm), D. Gareth Evans(Inserm), Rosalind A. Eeles(Université Claude Bernard Lyon 1), Louise Izatt(Guy's and St Thomas' NHS Foundation Trust), Carol Chu(Université Claude Bernard Lyon 1), Fiona Douglas(Institut Gustave Roussy), J. Paterson(Institut Gustave Roussy), Dominique Stoppa-Lyonnet(Centre François Baclesse), Claude Houdayer(Délégation Paris 5), Sylvie Mazoyer(Délégation Paris 5), Sophie Giraud(The Netherlands Cancer Institute), Christine Lasset(Université Claude Bernard Lyon 1), Audrey Remenieras(Institut Gustave Roussy), Olivier Caron(Radboud University Nijmegen), Agnès Hardouin(University Medical Center Utrecht), Pascaline Berthet(Centre François Baclesse), Frans B.L. Hogervorst(The Netherlands Cancer Institute), Matti A. Rookus(Leiden University Medical Center), Agnes Jager(Leiden University Medical Center), Ans van den Ouweland(Erasmus MC), Nicoline Hoogerbrugge(Radboud University Nijmegen), Rob B. van der Luijt(University Medical Center Utrecht), Hanne Meijers‐Heijboer(International Hereditary Cancer Center), E. Gómez(International Hereditary Cancer Center), Peter Devilee(Leiden University Medical Center), Maaike P.G. Vreeswijk(International Hereditary Cancer Center), Jan Lubiński(QIMR Berghofer Medical Research Institute), Anna Jakubowska(QIMR Berghofer Medical Research Institute), Jacek Gronwald(University of Utah), Tomasz Huzarski(Cancer Prevention Institute of California), Tomasz Byrski(The University of Melbourne), Bohdan Górski(The University of Melbourne), Cezary Cybulski(University of Utah), Amanda B. Spurdle(Fox Chase Cancer Center), Helene Holland(Peter MacCallum Cancer Centre), David E Goldgar(University of Cologne), Esther M. John(University of Cologne), John L. Hopper(Leipzig University), Melissa C. Southey(TUM Klinikum), Saundra S. Buys, Mary B. Daly(Christian-Albrechts-Universität zu Kiel), Mary Beth Terry(Düsseldorf University Hospital), Rita K. Schmutzler(Heidelberg University), Barbara Wappenschmidt(University of Pennsylvania), Christoph Engel(University of Pennsylvania), Alfons Meindl(University of Pennsylvania), Sabine Preisler‐Adams(Texas Oncology), Norbert Arnold(Roswell Park Comprehensive Cancer Center), Dieter Niederacher(NorthShore University HealthSystem), Christian Sutter(Tufts University), Susan M. Domchek(University of North Carolina at Chapel Hill), Katherine L. Nathanson(St. Elizabeth Healthcare), Timothy R. Rebbeck(New York University), Joanne L. Blum(Sheba Medical Center), Marion Piedmonte(Sheba Medical Center), Gustavo C. Rodriguez(Sheba Medical Center), Katie Wakeley(Sheba Medical Center), John F. Boggess(Cancer Care Ontario), Jack Basil(Cancer Care Ontario), Stephanie V. Blank(Mount Sinai Hospital), Eitan Friedman(Memorial Hospital), Bella Kaufman(Memorial Hospital), Yael Laitman(Albert Einstein College of Medicine), Roni Milgrom(Broad Institute), Irene L. Andrulis(Broad Institute), Gord Glendon(Lund University), Hilmi Özçelik(Lund University), Tomas Kirchhoff(Karolinska University Hospital), Joseph Vijai(Uppsala University), Mia M. Gaudet(Rigshospitalet), David Altshuler(Odense University Hospital), Candace Guiducci(Aarhus University Hospital), Niklas Loman(Fondazione IRCCS Istituto Nazionale dei Tumori), Katja Harbst(Fondazione IRCCS Istituto Nazionale dei Tumori), Johanna Rantala(European Institute of Oncology), Hans Ehrencrona(Centro di Riferimento Oncologico), Anne‐Marie Gerdes(Fondazione IRCCS Istituto Nazionale dei Tumori), Mads Thomassen(Hospital Clínico San Carlos), Lone Sunde(European Institute of Oncology), Paolo Peterlongo(Medical University of Vienna), Siranoush Manoukian(Medical University of Vienna), Bernardo Bonanni(National Cancer Institute), Alessandra Viel(National Cancer Institute), Paolo Radice(National Cancer Institute), Trinidad Caldés(Mayo Clinic), Miguel de la Hoya(Mayo Clinic), Christian F. Singer(Copenhagen University Hospital), Anneliese Fink-Retter(Copenhagen University Hospital), Mark H. Greene(Institut Català d'Oncologia), Phuong L Mai(Institut Català d'Oncologia), Jennifer T. Loud(Dana-Farber Cancer Institute), Lucia Guidugli(University College London), Noralane M. Lindor(University College London), Thomas van Overeem Hansen(Women's College Hospital), Finn C. Nielsen(Moffitt Cancer Center), Ignacio Blanco(Mayo Clinic), Conxi Lázaro(Spanish National Cancer Research Centre), Judy Garber(Spanish National Cancer Research Centre), Susan J. Ramus(Helsinki University Hospital), Simon A. Gayther(Helsinki University Hospital), Catherine Phelan(University of Pisa), Stephen Narod(University of California, San Francisco), Csilla I. Szabo(German Cancer Research Center), Javier Benítez(Fox Chase Cancer Center), Ana Osório(Istituto Oncologico Veneto), Heli Nevanlinna(Istituto Oncologico Veneto), Tuomas Heikkinen(City of Hope), Maria A. Caligo(Cedars-Sinai Medical Center), Mary Beattie(Beth Israel Deaconess Medical Center), Ute Hamann(The Ohio State University), Andrew K Godwin(City of Hope), Marco Montagna(University of Chicago Medical Center), Cinzia Casella(Centre hospitalier universitaire de Québec), Susan L. Neuhausen(Centre hospitalier universitaire de Québec), Beth Y Karlan(NorthShore University HealthSystem), Nadine Tung(Reykjavík University), Amanda Ewart Toland(QIMR Berghofer Medical Research Institute), Jeffrey N. Weitzel(Carmel Medical Center), O. I. Olopade(Carmel Medical Center), Jacques Simard(German Cancer Research Center), Penny Soucy(Universität Hamburg), Wendy S. Rubinstein(Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology), Aðalgeir Arason(Cancer Council Victoria), Gad Rennert(Cancer Council Victoria), Nicholas G. Martin(University of Sheffield), Grant W. Montgomery(University of Sheffield), Jenny Chang‐Claude(Dana-Farber Cancer Institute), Dieter Flesch-Janys(Princess Anne Hospital), Hiltrud Brauch(Université Claude Bernard Lyon 1), Gianluca Severi(National Centre of Scientific Research "Demokritos"), Laura Baglietto(Aristotle University of Thessaloniki), Angela Cox(University of California, Los Angeles), Simon S. Cross(Institut Gustave Roussy), Penelope Miron(University of London), Sue Gerty(University of London), William Tapper, Drakoulis Yannoukakos(La Ligue Contre le Cancer), George Fountzilas(The Netherlands Cancer Institute), Peter A Fasching(German Cancer Research Center), Matthias W Beckmann(Oulu University Hospital), Isabel dos‐Santos‐Silva(Oulu University Hospital), Julian Peto(Mayo Clinic), Diether Lambrechts(Mayo Clinic), R. Paridaens(Mayo Clinic in Florida), Thomas Rüdiger(Mayo Clinic in Florida), Asta Försti(University of Cambridge), Robert Winqvist(University of Cambridge), Katri Pylkäs(University of Cambridge), Robert B. Diasio(University of Cambridge), Adam M. Lee(University of Toronto), Jeanette E. Eckel‐Passow(Mayo Clinic in Florida), Celine M. Vachon(Children's Hospital of Philadelphia), Fiona M. Blows(QIMR Berghofer Medical Research Institute), Kristy Driver(University of Cambridge), Alison M. Dunning(Mayo Clinic), Paul D.P. Pharoah, Kenneth Offit, V. Shane Pankratz, Hakon Hakonarson(Leiden University Medical Center), Georgia Chenevix‐Trench, Douglas F. Easton, Fergus J. Couch

Nature Genetics

September 19, 2010

10.1038/ng.669

Cited by 342Open Access

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