Large-scale genotyping identifies 41 new loci associated with breast cancer risk

Kyriaki Michailidou; kConFab Investigators; Australian Ovarian Cancer Study Group; The GENICA (Gene Environment Interaction and Breast Cancer in Germany) Network; Per Hall; Anna González‐Neira; Maya Ghoussaini; Joe Dennis; Roger L. Milne; Marjanka K. Schmidt; Jenny Chang‐Claude; Stig E. Bojesen; Manjeet K. Bolla; Qin Wang; Ed Dicks; Andrew Lee; Clare Turnbull; Nazneen Rahman; Olivia Fletcher; Julian Peto; Lorna J. Gibson; Isabel dos‐Santos‐Silva; Heli Nevanlinna; Taru Muranen; Kristiina Aittomäki; Carl Blomqvist; Kamila Czene; Astrid Irwanto; Jianjun Liu; Quinten Waisfisz; Hanne Meijers‐Heijboer; Muriel A. Adank; Rob B. van der Luijt; Rebecca Hein; Norbert Dahmen; L. Beckman; Alfons Meindl; Rita K. Schmutzler; Bertram Müller‐Myhsok; Peter Lichtner; John L. Hopper; Melissa C. Southey; Enes Makalic; Daniel F. Schmidt; André G. Uitterlinden; Albert Hofman; David J. Hunter; Stephen J. Chanock; Daniel Vincent; François Bacot; Daniel C. Tessier; Sander Canisius; Lodewyk F.A. Wessels; Christopher A. Haiman; Mitul Shah; Robert Luben; Judith Brown; Craig Luccarini; Nils Schoof; Keith Humphreys; Jingmei Li; Børge G. Nordestgaard; Sune F. Nielsen; Henrik Flyger; Fergus J. Couch; Xianshu Wang; Celine M. Vachon; Kristen N. Stevens; Diether Lambrechts; Matthieu Moisse; Robert Paridaens; Marie‐Rose Christiaens; Anja Rudolph; Stefan Nickels; Dieter Flesch‐Janys; Nichola Johnson; Zoe Aitken; Kirsimari Aaltonen; Tuomas Heikkinen; Annegien Broeks; Laura J. van’t Veer; C. Ellen van der Schoot; Pascal Guénel; Thérèse Truong; Pierre Laurent‐Puig; F. Ménégaux; Frederik Marmé; Andreas Schneeweiß; Christof Sohn; Barbara Burwinkel; M. Pilar Zamora; José Ignacio Arias Pérez; Guillermo Pita; M. Rosario Alonso; Angela Cox; Ian W. Brock; Simon S. Cross; Malcolm Reed; Elinor J. Sawyer; Ian Tomlinson; Michael J. Kerin; Nicola Miller; Brian E. Henderson; Fredrick R. Schumacher; Loı̈c Le Marchand; Irene L. Andrulis; Julia A. Knight; Gord Glendon; Anna Marie Mulligan; Annika Lindblom; Sara Margolin; Maartje J. Hooning; Antoinette Hollestelle; Ans M.W. van den Ouweland; Agnes Jager; Minh Bui; Jennifer Stone; Gillian S. Dite; Carmel Apicella; Helen Tsimiklis; Graham G. Giles; Gianluca Severi; Laura Baglietto; Peter A. Fasching; Lothar Haeberle; Arif B. Ekici; Matthias W. Beckmann; Hermann Brenner; Heiko Müller; Volker Arndt; Christa Stegmaier; Anthony J. Swerdlow; Alan Ashworth; Nick Orr; Michael E. Jones; Jonine D. Figueroa; Jolanta Lissowska; Louise A. Brinton; Mark S. Goldberg; France Labrèche; Martine Dumont; Robert Winqvist; Katri Pylkäs; Arja Jukkola‐Vuorinen; Mervi Grip; Hiltrud Brauch; Ute Hamann; Thomas Brüning; Paolo Radice; Paolo Peterlongo; Siranoush Manoukian; Bernardo Bonanni; Peter Devilee; Rob A.�E.�M. Tollenaar; Caroline Seynaeve; Christi J. van Asperen; Anna Jakubowska; Jan Lubiński; Katarzyna Jaworska; Katarzyna Durda; Arto Mannermaa; Vesa Kataja; Veli-Matti Kosma; Jaana M. Hartikainen; Natalia Bogdanova; Natalia Antonenkova; Thilo Dörk; Vessela N. Kristensen; Hoda Anton‐Culver; Susan Slager; Amanda E. Toland; Stephen B. Edge; Florentia Fostira; Daehee Kang; Keun-Young Yoo; Dong‐Young Noh; Keitaro Matsuo; Hidemi Ito; Hiroji Iwata; Aiko Sueta; Anna H. Wu; Chiu-Chen Tseng; David Van Den Berg; Daniel O. Stram; Xiao‐Ou Shu; Wei Lu; Yu-Tang Gao; Hui Cai; Soo‐Hwang Teo; Cheng Har Yip; Sze Yee Phuah; Belinda K. Cornes; Mikael Hartman; Hui Miao; Wei Yen Lim; Jen-Hwei Sng; Kenneth Muir; Artitaya Lophatananon; Sarah Stewart‐Brown; Pornthep Siriwanarangsan; Chen‐Yang Shen; Chia-Ni Hsiung; Pei-Ei Wu; Shian-ling Ding; Suleeporn Sangrajrang; Valérie Gaborieau; Paul Brennan; James McKay; William J. Blot; Lisa B. Signorello; Qiuyin Cai; Wei Zheng; Sandra Deming-Halverson; Martha J. Shrubsole; Jirong Long; Jacques Simard; Montserrat García‐Closas; Paul D.P. Pharoah; Georgia Chenevix‐Trench; Alison M. Dunning; Javier Benı́tez; Douglas F. Easton

doi:10.1038/ng.2563

Large-scale genotyping identifies 41 new loci associated with breast cancer risk

Kyriaki Michailidou(University of Cambridge), kConFab Investigators(Karolinska Institutet), Australian Ovarian Cancer Study Group(Spanish National Cancer Research Centre), The GENICA (Gene Environment Interaction and Breast Cancer in Germany) Network(University of Cambridge), Per Hall(University of Cambridge), Anna González‐Neira(Spanish National Cancer Research Centre), Maya Ghoussaini(The Netherlands Cancer Institute), Joe Dennis(German Cancer Research Center), Roger L. Milne(Herlev Hospital), Marjanka K. Schmidt(University of Cambridge), Jenny Chang‐Claude(University of Cambridge), Stig E. Bojesen(University of Cambridge), Manjeet K. Bolla(University of Cambridge), Qin Wang(Institute of Cancer Research), Ed Dicks(Institute of Cancer Research), Andrew Lee(Institute of Cancer Research), Clare Turnbull(London School of Hygiene & Tropical Medicine), Nazneen Rahman(London School of Hygiene & Tropical Medicine), Olivia Fletcher(London School of Hygiene & Tropical Medicine), Julian Peto(University of Helsinki), Lorna J. Gibson(University of Helsinki), Isabel dos‐Santos‐Silva(University of Helsinki), Heli Nevanlinna(University of Helsinki), Taru Muranen(Karolinska Institutet), Kristiina Aittomäki(Genome Institute of Singapore), Carl Blomqvist(Genome Institute of Singapore), Kamila Czene(Amsterdam UMC Location Vrije Universiteit Amsterdam), Astrid Irwanto(Amsterdam UMC Location Vrije Universiteit Amsterdam), Jianjun Liu(Amsterdam UMC Location Vrije Universiteit Amsterdam), Quinten Waisfisz(University Medical Center Utrecht), Hanne Meijers‐Heijboer(German Cancer Research Center), Muriel A. Adank(Johannes Gutenberg University Mainz), Rob B. van der Luijt(Institute for Quality and Efficiency in Health Care), Rebecca Hein(Technical University of Munich), Norbert Dahmen(University of Cologne), L. Beckman(Max Planck Institute of Psychiatry), Alfons Meindl(Helmholtz Zentrum München), Rita K. Schmutzler(The University of Melbourne), Bertram Müller‐Myhsok(The University of Melbourne), Peter Lichtner(The University of Melbourne), John L. Hopper(The University of Melbourne), Melissa C. Southey(Erasmus MC), Enes Makalic(Erasmus MC), Daniel F. Schmidt(Harvard University), André G. Uitterlinden(National Cancer Institute), Albert Hofman(McGill University and Génome Québec Innovation Centre), David J. Hunter(McGill University and Génome Québec Innovation Centre), Stephen J. Chanock(McGill University and Génome Québec Innovation Centre), Daniel Vincent(The Netherlands Cancer Institute), François Bacot(The Netherlands Cancer Institute), Daniel C. Tessier(University of Southern California), Sander Canisius(University of Cambridge), Lodewyk F.A. Wessels(University of Cambridge), Christopher A. Haiman(University of Cambridge), Mitul Shah(University of Cambridge), Robert Luben(Karolinska Institutet), Judith Brown(Karolinska Institutet), Craig Luccarini(Genome Institute of Singapore), Nils Schoof(Herlev Hospital), Keith Humphreys(Herlev Hospital), Jingmei Li(Herlev Hospital), Børge G. Nordestgaard(Mayo Clinic), Sune F. Nielsen(Mayo Clinic), Henrik Flyger(Mayo Clinic in Florida), Fergus J. Couch(Mayo Clinic in Florida), Xianshu Wang, Celine M. Vachon, Kristen N. Stevens(KU Leuven), Diether Lambrechts(KU Leuven), Matthieu Moisse(German Cancer Research Center), Robert Paridaens(German Cancer Research Center), Marie‐Rose Christiaens(Universität Hamburg), Anja Rudolph(Institute of Cancer Research), Stefan Nickels(London School of Hygiene & Tropical Medicine), Dieter Flesch‐Janys(University of Helsinki), Nichola Johnson(University of Helsinki), Zoe Aitken(The Netherlands Cancer Institute), Kirsimari Aaltonen(The Netherlands Cancer Institute), Tuomas Heikkinen(Sanquin), Annegien Broeks(Inserm), Laura J. van’t Veer(Inserm), C. Ellen van der Schoot(Inserm), Pascal Guénel(Inserm), Thérèse Truong(Heidelberg University), Pierre Laurent‐Puig(Heidelberg University), F. Ménégaux(Heidelberg University), Frederik Marmé(Heidelberg University), Andreas Schneeweiß(Hospital Universitario La Paz), Christof Sohn(Hospital Monte Naranco), Barbara Burwinkel(Spanish National Cancer Research Centre), M. Pilar Zamora(Spanish National Cancer Research Centre), José Ignacio Arias Pérez(Yorkshire Cancer Research), Guillermo Pita(Yorkshire Cancer Research), M. Rosario Alonso(University of Sheffield), Angela Cox(Yorkshire Cancer Research), Ian W. Brock(National Health Service), Simon S. Cross(Centre for Human Genetics), Malcolm Reed(University Hospital Galway), Elinor J. Sawyer(University Hospital Galway), Ian Tomlinson(University of Southern California), Michael J. Kerin(University of Southern California), Nicola Miller(University of Hawaiʻi at Mānoa), Brian E. Henderson(Mount Sinai Hospital), Fredrick R. Schumacher(Mount Sinai Hospital), Loı̈c Le Marchand(Mount Sinai Hospital), Irene L. Andrulis(University of Toronto), Julia A. Knight(Karolinska Institutet), Gord Glendon(Karolinska Institutet), Anna Marie Mulligan(Erasmus MC), Annika Lindblom(Erasmus MC), Sara Margolin(Erasmus MC), Maartje J. Hooning(Erasmus MC), Antoinette Hollestelle(The University of Melbourne), Ans M.W. van den Ouweland(The University of Melbourne), Agnes Jager(The University of Melbourne), Minh Bui(The University of Melbourne), Jennifer Stone(The University of Melbourne), Gillian S. Dite(The University of Melbourne), Carmel Apicella(Cancer Council Victoria), Helen Tsimiklis(Cancer Council Victoria), Graham G. Giles(Universitätsklinikum Erlangen), Gianluca Severi(Universitätsklinikum Erlangen), Laura Baglietto(Friedrich-Alexander-Universität Erlangen-Nürnberg), Peter A. Fasching(Universitätsklinikum Erlangen), Lothar Haeberle(Heidelberg University), Arif B. Ekici(Heidelberg University), Matthias W. Beckmann(Heidelberg University), Hermann Brenner(Krebsregister Saarland), Heiko Müller(Institute of Cancer Research), Volker Arndt(Institute of Cancer Research), Christa Stegmaier(Institute of Cancer Research), Anthony J. Swerdlow(Institute of Cancer Research), Alan Ashworth(National Cancer Institute), Nick Orr(The Maria Sklodowska-Curie National Research Institute of Oncology), Michael E. Jones(National Cancer Institute), Jonine D. Figueroa(McGill University), Jolanta Lissowska(Université de Montréal), Louise A. Brinton(Centre hospitalier universitaire de Québec), Mark S. Goldberg(Oulu University Hospital), France Labrèche(Oulu University Hospital), Martine Dumont(Oulu University Hospital), Robert Winqvist(Oulu University Hospital), Katri Pylkäs(Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology), Arja Jukkola‐Vuorinen(German Cancer Research Center), Mervi Grip(Institute for Prevention and Occupational Medicine), Hiltrud Brauch(Fondazione IRCCS Istituto Nazionale dei Tumori), Ute Hamann(Fondazione IRCCS Istituto Nazionale dei Tumori), Thomas Brüning(Istituti di Ricovero e Cura a Carattere Scientifico), Paolo Radice(European Institute of Oncology), Paolo Peterlongo(Leiden University Medical Center), Siranoush Manoukian(Leiden University Medical Center), Bernardo Bonanni(Erasmus MC Cancer Institute), Peter Devilee(Leiden University Medical Center), Rob A.�E.�M. Tollenaar(Pomeranian Medical University), Caroline Seynaeve(Pomeranian Medical University), Christi J. van Asperen(Pomeranian Medical University), Anna Jakubowska(Pomeranian Medical University), Jan Lubiński(University of Eastern Finland), Katarzyna Jaworska(Kuopio University Hospital), Katarzyna Durda(University of Eastern Finland), Arto Mannermaa(University of Eastern Finland), Vesa Kataja(Medizinische Hochschule Hannover), Veli-Matti Kosma(N.N. Alexandrov National Cancer Centre), Jaana M. Hartikainen(Medizinische Hochschule Hannover), Natalia Bogdanova(University of Oslo), Natalia Antonenkova(University of California, Irvine), Thilo Dörk(Mayo Clinic in Florida), Vessela N. Kristensen(The Ohio State University), Hoda Anton‐Culver(Roswell Park Comprehensive Cancer Center), Susan Slager(National Centre of Scientific Research "Demokritos"), Amanda E. Toland(Seoul National University), Stephen B. Edge(Seoul National University), Florentia Fostira(Seoul National University), Daehee Kang(Aichi Cancer Center), Keun-Young Yoo(Aichi Cancer Center), Dong‐Young Noh(Aichi Cancer Center), Keitaro Matsuo(Aichi Cancer Center), Hidemi Ito(University of Southern California), Hiroji Iwata(University of Southern California), Aiko Sueta(University of Southern California), Anna H. Wu(University of Southern California), Chiu-Chen Tseng(Vanderbilt University), David Van Den Berg(Shanghai Municipal Center For Disease Control Prevention), Daniel O. Stram(Shanghai Cancer Institute), Xiao‐Ou Shu(Vanderbilt University), Wei Lu(Cancer Research Malaysia), Yu-Tang Gao(University Malaya Medical Centre), Hui Cai(Cancer Research Malaysia), Soo‐Hwang Teo(National University of Singapore), Cheng Har Yip(National University of Singapore), Sze Yee Phuah(National University of Singapore), Belinda K. Cornes(National University of Singapore), Mikael Hartman(National University of Singapore), Hui Miao(University of Warwick), Wei Yen Lim(University of Warwick), Jen-Hwei Sng(University of Warwick), Kenneth Muir(Ministry of Public Health), Artitaya Lophatananon(Institute of Biomedical Sciences, Academia Sinica), Sarah Stewart‐Brown(Institute of Biomedical Sciences, Academia Sinica), Pornthep Siriwanarangsan(Institute of Biomedical Sciences, Academia Sinica), Chen‐Yang Shen(Kang-Ning Junior College of Medical Care and Management), Chia-Ni Hsiung(National Cancer Institute of Thailand), Pei-Ei Wu(Centre international de recherche sur le cancer), Shian-ling Ding(Centre international de recherche sur le cancer), Suleeporn Sangrajrang(Centre international de recherche sur le cancer), Valérie Gaborieau(Vanderbilt University), Paul Brennan(Vanderbilt University), James McKay(Vanderbilt University), William J. Blot(Vanderbilt University), Lisa B. Signorello(Vanderbilt University), Qiuyin Cai(Vanderbilt University), Wei Zheng(Vanderbilt University), Sandra Deming-Halverson(Centre hospitalier universitaire de Québec), Martha J. Shrubsole(Institute of Cancer Research), Jirong Long(University of Cambridge), Jacques Simard(QIMR Berghofer Medical Research Institute), Montserrat García‐Closas(University of Cambridge), Paul D.P. Pharoah(Centre for Biomedical Network Research on Rare Diseases), Georgia Chenevix‐Trench(University of Cambridge), Alison M. Dunning, Javier Benı́tez, Douglas F. Easton

Nature Genetics

March 27, 2013

10.1038/ng.2563

Cited by 1,105Open Access

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