Evolutionary and Biomedical Insights from the Rhesus Macaque Genome
Richard A. Gibbs(Texas Biomedical Research Institute), Jeffrey Rogers(Texas Biomedical Research Institute), Michael G. Katze(Texas Biomedical Research Institute), Roger E. Bumgarner(Texas Biomedical Research Institute), George M. Weinstock(Texas Biomedical Research Institute), Elaine R. Mardis(Texas Biomedical Research Institute), Karin Remington(Texas Biomedical Research Institute), Robert L. Strausberg(Texas Biomedical Research Institute), J. Craig Venter(Texas Biomedical Research Institute), Richard K. Wilson(Texas Biomedical Research Institute), Mark A. Batzer(Texas Biomedical Research Institute), Carlos D. Bustamante(Texas Biomedical Research Institute), Evan E. Eichler(Texas Biomedical Research Institute), Matthew W. Hahn(Texas Biomedical Research Institute), Ross C. Hardison(Texas Biomedical Research Institute), Kateryna D. Makova(Texas Biomedical Research Institute), Webb Miller(Texas Biomedical Research Institute), Aleksandar Milosavljevic(Texas Biomedical Research Institute), Robert E. Palermo(Texas Biomedical Research Institute), Adam Siepel(Texas Biomedical Research Institute), James M. Sikela(Texas Biomedical Research Institute), Tony Attaway(Texas Biomedical Research Institute), Stephanie Bell(Texas Biomedical Research Institute), Kelly E. Bernard(Texas Biomedical Research Institute), Christian Buhay(Texas Biomedical Research Institute), Mimi N. Chandrabose(Texas Biomedical Research Institute), Marvin Dao(Texas Biomedical Research Institute), Clay Davis(Texas Biomedical Research Institute), Kimberly D. Delehaunty(Texas Biomedical Research Institute), Yan Ding(Texas Biomedical Research Institute), Huyen Dinh(Texas Biomedical Research Institute), Shannon Dugan-Rocha(Texas Biomedical Research Institute), Lucinda A. Fulton(Texas Biomedical Research Institute), Ramatu Ayiesha Gabisi(Texas Biomedical Research Institute), Toni T. Garner(Texas Biomedical Research Institute), Jennifer Godfrey(Texas Biomedical Research Institute), Alicia Hawes(Texas Biomedical Research Institute), Judith Hernandez(Texas Biomedical Research Institute), Sandra Hines(Texas Biomedical Research Institute), Michael Holder(Texas Biomedical Research Institute), Jennifer Hume(Texas Biomedical Research Institute), Shalini N. Jhangiani(Texas Biomedical Research Institute), Vandita Joshi(Texas Biomedical Research Institute), Ziad Khan(Texas Biomedical Research Institute), Ewen F. Kirkness(Texas Biomedical Research Institute), Andrew Cree(Texas Biomedical Research Institute), R. Gerald Fowler(Texas Biomedical Research Institute), Sandra Lee(Texas Biomedical Research Institute), Lora Lewis(Texas Biomedical Research Institute), Zhangwan Li(Texas Biomedical Research Institute), Yih-shin Liu(Texas Biomedical Research Institute), Stephanie Moore(Texas Biomedical Research Institute), Donna M. Muzny(Texas Biomedical Research Institute), Lynne V. Nazareth(Texas Biomedical Research Institute), Dinh Ngoc Ngo(Texas Biomedical Research Institute), Geoffrey Okwuonu(Texas Biomedical Research Institute), Grace Pai(Texas Biomedical Research Institute), David L. Parker(Texas Biomedical Research Institute), Heidie A. Paul(Texas Biomedical Research Institute), Cynthia Pfannkoch(Texas Biomedical Research Institute), Craig Pohl(Texas Biomedical Research Institute), Yu-Hui Rogers(Texas Biomedical Research Institute), San Juana Ruiz(Texas Biomedical Research Institute), Aniko Sabo(Texas Biomedical Research Institute), Jireh Santibanez(Texas Biomedical Research Institute), Brian Schneider(Texas Biomedical Research Institute), Scott M. Smith(Texas Biomedical Research Institute), Erica Sodergren(Texas Biomedical Research Institute), Amanda F. Svatek(Texas Biomedical Research Institute), Teresa R. Utterback(Texas Biomedical Research Institute), Selina Vattathil(Texas Biomedical Research Institute), Wesley C. Warren(Texas Biomedical Research Institute), Courtney White(Texas Biomedical Research Institute), Asif Chinwalla(Texas Biomedical Research Institute), Yucheng Feng(Texas Biomedical Research Institute), Aaron L. Halpern(Texas Biomedical Research Institute), LaDeana W. Hillier(Texas Biomedical Research Institute), Xiaoqiu Huang(Texas Biomedical Research Institute), Pat Minx(Texas Biomedical Research Institute), Joanne O. Nelson(Texas Biomedical Research Institute), Kymberlie Pepin(Texas Biomedical Research Institute), Xiang Qin(Texas Biomedical Research Institute), Granger G. Sutton(Texas Biomedical Research Institute), Eli Venter(Texas Biomedical Research Institute), Brian P. Walenz(Texas Biomedical Research Institute), John W. Wallis(Texas Biomedical Research Institute), Kim C. Worley(Texas Biomedical Research Institute), Shiaw‐Pyng Yang(Texas Biomedical Research Institute), Steven M. Jones(Texas Biomedical Research Institute), Marco A. Marra(Texas Biomedical Research Institute), Mariano Rocchi(Texas Biomedical Research Institute), Jacqueline E. Schein(Texas Biomedical Research Institute), Robert Baertsch(Texas Biomedical Research Institute), Laura Clarke(Texas Biomedical Research Institute), Miklós Csürös(Texas Biomedical Research Institute), Jarret Glasscock(Texas Biomedical Research Institute), R. Alan Harris(Texas Biomedical Research Institute), Paul Havlak(Texas Biomedical Research Institute), Andrew Jackson(Texas Biomedical Research Institute), Huaiyang Jiang(Texas Biomedical Research Institute), Yue Liu(Texas Biomedical Research Institute), D. Messina(Texas Biomedical Research Institute), Yufeng Shen(Texas Biomedical Research Institute), Henry Song(Texas Biomedical Research Institute), Todd Wylie(Texas Biomedical Research Institute), Lan Zhang(Texas Biomedical Research Institute), Ewan Birney(Texas Biomedical Research Institute), Kyudong Han(Texas Biomedical Research Institute), Miriam K. Konkel(Texas Biomedical Research Institute), Jungnam Lee(Texas Biomedical Research Institute), Arian F. A. Smit(Texas Biomedical Research Institute), Brygg Ullmer(Texas Biomedical Research Institute), Hui Wang(Texas Biomedical Research Institute), Jinchuan Xing(Texas Biomedical Research Institute), Richard Burhans(Texas Biomedical Research Institute), Ze Cheng(Texas Biomedical Research Institute), John Karro(Texas Biomedical Research Institute), Jian Ma(Texas Biomedical Research Institute), Brian J. Raney(Texas Biomedical Research Institute), Xinwei She(Texas Biomedical Research Institute), Michael J. Cox(Texas Biomedical Research Institute), Jeffery P. Demuth(Texas Biomedical Research Institute), Laura Dumas(Texas Biomedical Research Institute), Sang-Gook Han(Texas Biomedical Research Institute), Janet A. Hopkins(Texas Biomedical Research Institute), Anis Karimpour‐Fard(Texas Biomedical Research Institute), Young Ho Kim(Texas Biomedical Research Institute), Jonathan R. Pollack(Texas Biomedical Research Institute), Tomáš Vinař(Texas Biomedical Research Institute), Charles Addo‐Quaye(Texas Biomedical Research Institute), Jeremiah D. Degenhardt(Texas Biomedical Research Institute), Alexandra Denby(Texas Biomedical Research Institute), Melissa J. Hubisz(Texas Biomedical Research Institute), Amit Indap(Texas Biomedical Research Institute), Carolin Kosiol(Texas Biomedical Research Institute), Bruce T. Lahn(Texas Biomedical Research Institute), Heather A. Lawson(Texas Biomedical Research Institute), Alison Marklein(Texas Biomedical Research Institute), Rasmus Nielsen(Texas Biomedical Research Institute), Eric J. Vallender(Texas Biomedical Research Institute), Andrew G. Clark(Texas Biomedical Research Institute), Betsy Ferguson(Texas Biomedical Research Institute), Ryan D. Hernandez(Texas Biomedical Research Institute), Kashif Hirani(Texas Biomedical Research Institute), Hildegard Kehrer‐Sawatzki(Texas Biomedical Research Institute), Jessica Kolb(Texas Biomedical Research Institute), Shobha Patil(Texas Biomedical Research Institute), Lingling Pu(Texas Biomedical Research Institute), Yanru Ren(Texas Biomedical Research Institute), David Glenn Smith(Texas Biomedical Research Institute), David A. Wheeler(Texas Biomedical Research Institute), Ian Schenck(Texas Biomedical Research Institute), Edward V. Ball(Texas Biomedical Research Institute), Rui Chen(Texas Biomedical Research Institute), D.N. Cooper(Texas Biomedical Research Institute), Belinda Giardine(Texas Biomedical Research Institute), Fan Hsu(Texas Biomedical Research Institute), W. James Kent(Texas Biomedical Research Institute), Arthur M. Lesk(Texas Biomedical Research Institute), David L. Nelson(Texas Biomedical Research Institute), William E. O’Brien(Texas Biomedical Research Institute), Kay Prüfer(Texas Biomedical Research Institute), Peter D. Stenson(Texas Biomedical Research Institute), James C. Wallace(Texas Biomedical Research Institute), Ke HUI(Texas Biomedical Research Institute), Xiaoming Liu(Texas Biomedical Research Institute), Peng Wang(Texas Biomedical Research Institute), Andy Peng Xiang(Texas Biomedical Research Institute), Fan Yang(Texas Biomedical Research Institute), Galt P Barber(Texas Biomedical Research Institute), David Haussler(Texas Biomedical Research Institute), Donna Karolchik(Texas Biomedical Research Institute), Andy D. Kern(Texas Biomedical Research Institute), Robert M. Kuhn(Texas Biomedical Research Institute), Kayla Smith(Texas Biomedical Research Institute), Ann S. Zwieg(Texas Biomedical Research Institute)
Cited by 1,436Open Access
Abstract
The rhesus macaque (Macaca mulatta) is an abundant primate species that diverged from the ancestors of Homo sapiens about 25 million years ago. Because they are genetically and physiologically similar to humans, rhesus monkeys are the most widely used nonhuman primate in basic and applied biomedical research. We determined the genome sequence of an Indian-origin Macaca mulatta female and compared the data with chimpanzees and humans to reveal the structure of ancestral primate genomes and to identify evidence for positive selection and lineage-specific expansions and contractions of gene families. A comparison of sequences from individual animals was used to investigate their underlying genetic diversity. The complete description of the macaque genome blueprint enhances the utility of this animal model for biomedical research and improves our understanding of the basic biology of the species.
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