Potential Regulatory Function of Human Dendritic Cells Expressing Indoleamine 2,3-Dioxygenase
David H. Munn(Augusta University), Madhav Sharma(Augusta University), Jeffrey R. Lee(Augusta University), Kanchan G. Jhaver(Augusta University), Theodore S. Johnson(Augusta University), Derin B. Keskin(Augusta University), Brendan Marshall(Augusta University), Phillip Chandler(Augusta University), Scott Antonia(Moffitt Cancer Center), Russell Burgess(Augusta University), Craig L. Slingluff(University of Virginia), Andrew L. Mellor(Augusta University)
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Abstract
Antigen-presenting cells (APCs) can induce tolerance or immunity. We describe a subset of human APCs that express indoleamine 2,3-dioxygenase (IDO) and inhibit T cell proliferation in vitro. IDO-positive APCs constituted a discrete subset identified by coexpression of the cell-surface markers CD123 and CCR6. In the dendritic cell (DC) lineage, IDO-mediated suppressor activity was present in fully mature as well as immature CD123+ DCs. IDO+ DCs could also be readily detected in vivo, which suggests that these cells may represent a regulatory subset of APCs in humans.
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