Characterization of a Novel Coronavirus Associated with Severe Acute Respiratory Syndrome
Paul A. Rota(Centers for Disease Control and Prevention), M. Steven Oberste(Centers for Disease Control and Prevention), Stephan S. Monroe(Centers for Disease Control and Prevention), W. Allan Nix(Centers for Disease Control and Prevention), Raymond P. Campagnoli(Centers for Disease Control and Prevention), Joseph P. Icenogle(Centers for Disease Control and Prevention), Silvia Peñaranda(Centers for Disease Control and Prevention), Bettina Bankamp(Centers for Disease Control and Prevention), Kaija Maher(Centers for Disease Control and Prevention), Min-hsin Chen(Centers for Disease Control and Prevention), Suxiong Tong(Centers for Disease Control and Prevention), Azaibi Tamin(Centers for Disease Control and Prevention), Luis Lowe(Centers for Disease Control and Prevention), Michael Frace(Centers for Disease Control and Prevention), Joseph L. DeRisi(Centers for Disease Control and Prevention), Qi Chen(Centers for Disease Control and Prevention), David Wang(Centers for Disease Control and Prevention), Dean D. Erdman(Centers for Disease Control and Prevention), Teresa C. T. Peret(Centers for Disease Control and Prevention), Cara C. Burns(Centers for Disease Control and Prevention), Thomas G. Ksiazek(Centers for Disease Control and Prevention), Pierre E. Rollin(Centers for Disease Control and Prevention), Anthony Sanchez(Centers for Disease Control and Prevention), Stephanie Liffick(Centers for Disease Control and Prevention), Brian Holloway(Centers for Disease Control and Prevention), Josef Limor(Centers for Disease Control and Prevention), Karen A. McCaustland(Centers for Disease Control and Prevention), Melissa Olsen-Rasmussen(Centers for Disease Control and Prevention), Ron A. M. Fouchier(Centers for Disease Control and Prevention), Stephan Günther(Centers for Disease Control and Prevention), Albert D. M. E. Osterhaus(Centers for Disease Control and Prevention), Christian Drosten(Centers for Disease Control and Prevention), Mark A. Pallansch(Centers for Disease Control and Prevention), Larry J. Anderson(Centers for Disease Control and Prevention), William J. Bellini(Centers for Disease Control and Prevention)
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Abstract
In March 2003, a novel coronavirus (SARS-CoV) was discovered in association with cases of severe acute respiratory syndrome (SARS). The sequence of the complete genome of SARS-CoV was determined, and the initial characterization of the viral genome is presented in this report. The genome of SARS-CoV is 29,727 nucleotides in length and has 11 open reading frames, and its genome organization is similar to that of other coronaviruses. Phylogenetic analyses and sequence comparisons showed that SARS-CoV is not closely related to any of the previously characterized coronaviruses.
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