Whole-Exome Sequencing Identifies Rare and Low-Frequency Coding Variants Associated with LDL Cholesterol
Leslie A. Lange(University of North Carolina at Chapel Hill), Youna Hu(University of Michigan), He Zhang(University of Michigan), Chenyi Xue(University of Michigan), Ellen M. Schmidt(University of Michigan), Zheng-Zheng Tang(University of North Carolina at Chapel Hill), Chris Bizon(Renaissance Computing Institute), Ethan M. Lange(University of North Carolina at Chapel Hill), Joshua D. Smith(University of Washington), Emily H. Turner(University of Washington), Goo Jun(University of Michigan), Hyun Min Kang(University of Michigan), Gina M. Peloso(Broad Institute), Paul L. Auer(Fred Hutch Cancer Center), Kuo-ping Li(University of Michigan), Jason Flannick(Broad Institute), Ji Zhang(University of Michigan), Christian Fuchsberger(University of Michigan), Kyle J. Gaulton(Centre for Human Genetics), Cecilia M. Lindgren(Centre for Human Genetics), Adam E. Locke(University of Michigan), Alisa K. Manning(Broad Institute), Xueling Sim(University of Michigan), Manuel A. Rivas(Centre for Human Genetics), Oddgeir L. Holmen(Norwegian University of Science and Technology), Omri Gottesman(Icahn School of Medicine at Mount Sinai), Yingchang Lu(Icahn School of Medicine at Mount Sinai), Douglas M. Ruderfer(Icahn School of Medicine at Mount Sinai), Eli A. Stahl(Icahn School of Medicine at Mount Sinai), Qing Duan(University of North Carolina at Chapel Hill), Yun Li(University of North Carolina at Chapel Hill), Peter Durda(University of Vermont), Shuo Jiao(Fred Hutch Cancer Center), Aaron Isaacs(Erasmus MC), Albert Hofman(Erasmus MC), Joshua C. Bis(University of Washington), Adolfo Correa(University of Mississippi Medical Center), Michael Griswold(University of Mississippi Medical Center), Jóhanna Jakobsdóttir(Icelandic Heart Association), Albert V. Smith(University of Iceland), Pamela J. Schreiner(University of Minnesota), Mary F. Feitosa, Qunyuan Zhang, Jennifer E. Huffman(Institute of Genetics and Cancer), Jacy R. Crosby(The University of Texas Health Science Center at Houston), Christina L. Wassel(University of Pittsburgh), Ron Do(Broad Institute), Nora Franceschini(University of North Carolina at Chapel Hill), Lisa W. Martin(George Washington University), Jennifer G. Robinson(University of Iowa), Themistocles L. Assimes(Stanford University), David R. Crosslin(University of Washington), Elisabeth A. Rosenthal(University of Washington Medical Center), Michael Y. Tsai(University of Minnesota), Mark J. Rieder(University of Washington), Deborah Farlow(Broad Institute), Aaron R. Folsom(University of Minnesota), Thomas Lumley(University of Auckland), Ervin R. Fox(University of Mississippi Medical Center), Christopher S. Carlson(Fred Hutch Cancer Center), Ulrike Peters(Fred Hutch Cancer Center), Rebecca D. Jackson(The Ohio State University), Cornelia M. van Duijn(Erasmus MC), André G. Uitterlinden(Erasmus MC), Daniel Levy(National Heart Lung and Blood Institute), Jerome I. Rotter(The Lundquist Institute), Herman A. Taylor(Tougaloo College), Vilmundur Guðnason(University of Iceland), David S. Siscovick(University of Washington), Myriam Fornage(The University of Texas Health Science Center at Houston), Ingrid B. Borecki, Caroline Hayward(Institute of Genetics and Cancer), Igor Rudan(University of Edinburgh), Y. Eugene Chen(University of Michigan), Erwin P. Böttinger(Icahn School of Medicine at Mount Sinai), Ruth J. F. Loos(Icahn School of Medicine at Mount Sinai), Pål Sætrom(Norwegian University of Science and Technology), Kristian Hveem(Norwegian University of Science and Technology), Michael Boehnke(University of Michigan), Leif Groop(Lund University), Mark I. McCarthy(Churchill Hospital), Thomas Meitinger(Helmholtz Zentrum München), Christie M. Ballantyne(Houston Methodist), Stacey Gabriel(Broad Institute), Christopher J. O’Donnell(Johns Hopkins University), Wendy S. Post(University of North Carolina at Chapel Hill), Kari E. North(University of North Carolina at Chapel Hill), Alexander P. Reiner(University of Washington), Eric Boerwinkle(Group Health Cooperative), Bruce M. Psaty(Broad Institute), David Altshuler(Broad Institute), Sekar Kathiresan(Broad Institute), Dan-Yu Lin(University of North Carolina at Chapel Hill), Gail P. Jarvik(Boston University), L. Adrienne Cupples(Fred Hutch Cancer Center), Charles Kooperberg(Jackson Memorial Hospital), James G. Wilson(University of Washington), Deborah A. Nickerson(University of Washington), Gonçalo R. Abecasis(University of Michigan), Stephen S. Rich(University of Vermont), Russell P. Tracy(University of Vermont), Cristen J. Willer(Broad Institute), Stacey Gabriel(Broad Institute), David Altshuler(Broad Institute), Gonçalo R. Abecasis(University of Michigan), Hooman Allayee, Sharon Cresci(University of Washington), Mark J. Daly, Paul I. W. de Bakker(Churchill Hospital), Mark A. DePristo(Broad Institute), Ron Do(Broad Institute), Peter Donnelly(Broad Institute), Deborah Farlow(Broad Institute), Tim Fennell, Kiran Garimella, Stanley L. Hazen(University of Michigan), Youna Hu(University of Michigan), Daniel M. Jordan(University of Michigan), Goo Jun(Broad Institute), Sekar Kathiresan(Broad Institute), Hyun Min Kang(University of Michigan), Adam Kieżun, Guillaume Lettre(University of North Carolina at Chapel Hill), Bingshan Li(University of North Carolina at Chapel Hill), Mingyao Li, Christopher Newton‐Cheh, Sandosh Padmanabhan(Broad Institute), Gina M. Peloso(Broad Institute), Sara L. Pulit, Daniel J. Rader(Broad Institute), David Reich, Muredach P. Reilly(Centre for Human Genetics), Manuel A. Rivas(Centre for Human Genetics), Steven M. Schwartz, Laura J. Scott(University of Washington), David S. Siscovick(University of Washington), John A. Spertus, Nathaniel O. Stitziel, Nina Stoletzki, Shamil Sunyaev, Benjamin F. Voight(University of Michigan), Cristen J. Willer(University of Michigan), Stephen S. Rich(University of Virginia), Ermeg L. Akylbekova, Larry D. Atwood(Houston Methodist), Christie M. Ballantyne(Houston Methodist), Maja Barbalić, R. Graham Barr, Emelia J. Benjamin(University of Washington), Joshua C. Bis(University of Washington), Eric Boerwinkle(The University of Texas Health Science Center at Houston), Donald W. Bowden(University of Iowa), Jennifer A. Brody, Matthew J. Budoff, Greg Burke, Sarah G. Buxbaum, Jeff Carr(University of Michigan), Donna T. Chen(University of Michigan), Ida Y. Chen(University of Michigan), Wei‐Min Chen, Patrick Concannon(The University of Texas Health Science Center at Houston), Jacy R. Crosby(Boston University), L. Adrienne Cupples(Framingham Heart Study), Ralph B. D’Agostino, Anita L. DeStefano(University of Iceland), Albert W. Dreisbach, Josée Dupuis(University of Vermont), Jon Peter Durda, Jaclyn Ellis(University of Minnesota), Aaron R. Folsom(University of Minnesota), Myriam Fornage(University of Mississippi Medical Center), Caroline S. Fox(University of Mississippi Medical Center), Ervin R. Fox(University of Mississippi Medical Center), Vincent Funari, Santhi K. Ganesh, Julius M. Gardin(Broad Institute), David C. Goff(University of Michigan), Ora Gordon, Wayne W. Grody, Myron Gross, Xiuqing Guo, Ira M. Hall, Nancy L. Heard‐Costa, Susan R. Heckbert, Nicholas H. Heintz, David M. Herrington, DeMarc A. Hickson, Jie Huang, Shih‐Jen Hwang(University of Washington), David R. Jacobs, Nancy S. Jenny, Andrew D. Johnson, Craig Johnson, Steven M. Kawut, Richard A. Kronmal, Raluca Kurz(University of North Carolina at Chapel Hill), Ethan M. Lange(University of North Carolina at Chapel Hill), Leslie A. Lange(University of North Carolina at Chapel Hill), Martin G. Larson(Churchill Hospital), Mark Lawson, Cora E. Lewis(National Heart Lung and Blood Institute), Daniel Levy(University of North Carolina at Chapel Hill), Dalin Li(University of North Carolina at Chapel Hill), Honghuang Lin, Chunyu Liu, Jiankang Liu, Kiang Liu, Xiaoming Liu, Ching‐Ti Liu, W.T. Longstreth, Cay Loria(University of Auckland), Thomas Lumley(University of Auckland), Kathryn L. Lunetta, Aaron J. Mackey, Rachel H. Mackey(National Heart Lung and Blood Institute), Ani Manichaikul(Tougaloo College), Taylor J. Maxwell, Barbara McKnight, James B. Meigs, Alanna C. Morrison, Solomon K. Musani, Josyf C. Mychaleckyj(University of Iowa), Jennifer A. Nettleton(University of North Carolina at Chapel Hill), Kari E. North(University of North Carolina at Chapel Hill), Christopher J. O’Donnell(National Heart Lung and Blood Institute), Daniel S. OʼLeary, Frank S Ong, Walter Palmas, James S. Pankow, Nathan Pankratz(Fred Hutch Cancer Center), Shom Paul, Marco Pérez, Sharina D. Person, Joseph F. Polak(Johns Hopkins University), Wendy S. Post(Group Health Cooperative), Bruce M. Psaty(University of Minnesota), Aaron R. Quinlan, Leslie J. Raffel, Ramachandran S. Vasan(University of Washington), Alex P. Reiner(University of Washington), Kenneth Rice(The Lundquist Institute), Jerome I. Rotter(The Lundquist Institute), Jill P. Sanders(University of Minnesota), Pamela J. Schreiner(University of Minnesota), Sudha Seshadri, Steve Shea(University of Virginia), Stephen Sidney, Kevin A.T. Silverstein(University of Iceland), Nicholas L. Smith, Nona Sotoodehnia, Asoke Srinivasan(Tougaloo College), Herman A. Taylor(Tougaloo College), Kent D. Taylor(Helmholtz Zentrum München), Fridtjof Thomas(University of Vermont), Russell P. Tracy(University of Vermont), Michael Y. Tsai(University of Minnesota), Kelly A. Volcik(University of Pittsburgh), Chrstina L. Wassel(University of Pittsburgh), Karol Watson(Broad Institute), Gina S. Wei(Johns Hopkins University), Wendy White, Kerri L. Wiggins, Jemma B. Wilk, O. Dale Williams(Jackson Memorial Hospital), G. Wilson(Jackson Memorial Hospital), James G. Wilson(Jackson Memorial Hospital), Phillip Wolf, Neil A. Zakai, John Hardy, James F. Meschia(University of Michigan), Michael A. Nalls, Andrew B. Singleton, Brad Worrall, Michael J. Bamshad, Kathleen C. Barnes, Ibrahim Abdulhamid, Frank J. Accurso(University of North Carolina at Chapel Hill), Ran D. Anbar, Terri Beaty, Abigail W. Bigham, Phillip Black(University of Michigan), Eugene R. Bleecker, Kati J. Buckingham, Anne Marie Cairns(National Heart Lung and Blood Institute), Daniel B. Caplan, Barbara A. Chatfield(University of Minnesota), Aaron Chidekel(University of Michigan), Michael Cho, David C. Christiani, James D. Crapo, Julia M. Crouch, Denise Daley, Anthony T. Dang, Hong Dang, Alicia De Paula, J. DeCelie-Germana, Allen DozorMitch Drumm, Maynard Dyson, Julia Emerson, Mary J. Emond(Helmholtz Zentrum München), Thomas W. Ferkol, Robert Fink, Cassandra Foster(University of Washington), Deborah Froh(University of North Carolina at Chapel Hill), Li Gao, William M. Gershan, Ronald L. Gibson, Elizabeth Godwin, Magdalen Gondor, Héctor Gutiérrez, Nadia N. Hansel, Paul M. Hassoun(Fred Hutch Cancer Center), Peter Hiatt, John E. Hokanson, Michelle S. Howenstine, Laura K. Hummer, Jamshed F. Kanga, Yoonhee Kim, Michael R. Knowles(University of Michigan), Michael W. Konstan(Helmholtz Zentrum München), Thomas Lahiri, Nan M. Laird(University of North Carolina at Chapel Hill), Christoph Lange(University of North Carolina at Chapel Hill), Lin Lin(University of North Carolina at Chapel Hill), Xihong Lin, Tin L. Louie(Broad Institute), David R. Lynch, Barry J. Make(George Washington University), Thomas R. Martin, Steve C. Mathai, Rasika A. Mathias, John McNamara, Sharon McNamara(University of Washington), Deborah A. Meyers, Susan L. Millard(Fred Hutch Cancer Center), Peter J. Mogayzel, Richard B. Moss, Tanda Murray, Dennis W. Nielson, Blakeslee E. Noyes, Wanda K. O’Neal(Broad Institute), David Orenstein, Brian O’Sullivan, Rhonda G. Pace(Fred Hutch Cancer Center), Peter D. Paré, H. Worth Parker, Mary Ann Passero, Elizabeth A. Perkett(Boston University), Adrienne Prestridge, Nicholas Rafaels, Bonnie Ramsey, Elizabeth A. Regan(Centre for Human Genetics), Clement L. Ren, George Retsch‐Bogart(University of Michigan), Michael J. Rock(University of Washington Medical Center), Antony Rosen, Margaret Rosenfeld, Ingo Ruczinski, Andrew Sanford(Broad Institute), David J. Schaeffer(University of Vermont), Cindy Sell(National Heart Lung and Blood Institute), Daniel P. Sheehan, Edwin K. Silverman(Massachusetts General Hospital), Don D. Sin, Terry Spencer, J. Stonebraker, Holly K. Tabor, Laurie Varlotta, Candelaria Vergara, Robert Weiss, Fred Wigley, Robert A. Wise, Fred A. Wright(Churchill Hospital), Mark M. Wurfel, Robert Zanni, Fei Zou(University of Washington), Deborah A. Nickerson(University of Washington), Mark J. Rieder(University of Washington), Phil Green, Jay Shendure, Joshua M. Akey, Carlos D. Bustamante(University of Washington), David R. Crosslin(University of Washington), Evan E. Eichler(University of Mississippi Medical Center), Phillips Fox(University of Michigan), Wenqing Fu(University of Michigan), Allan Gordon, Simon Gravel(University of Washington), Gail P. Jarvik(University of Washington Medical Center), Jill M. Johnsen(University of Michigan), Mengyuan Kan, Eimear E. Kenny, Jeffrey M. Kidd, Fremiet Lara-Garduno, Suzanne M. Leal, Dajiang J. Liu, Sean McGee, Timothy D. O’Connor, Bryan Paeper, Peggy D. Robertson, Joshua D. Smith(University of Washington), Jeffrey Staples(University of Washington), Jacob A. Tennessen, Emily H. Turner(University of Washington), Gao Wang(The Ohio State University), Yi Qian(Fred Hutch Cancer Center), Rebecca D. Jackson(Fred Hutch Cancer Center), Ulrike Peters(Fred Hutch Cancer Center), Christopher S. Carlson(Fred Hutch Cancer Center), Garnet L. Anderson(Stanford University), Hoda Anton‐Culver(Fred Hutch Cancer Center), Themistocles L. Assimes(Stanford University), Paul L. Auer(Fred Hutch Cancer Center), Shirley A.A. Beresford, Chris Bizon(Renaissance Computing Institute), Henry R. Black, Robert L. Brunner, Robert G. Brzyski, Dale R. Burwen, Bette J. Caan, Cara L. Carty, Rowan T. Chlebowski, Steven R. Cummings, J. David Curb(University of North Carolina at Chapel Hill), Charles B. Eaton(University of North Carolina at Chapel Hill), Leslie Ford, Nora Franceschini(University of North Carolina at Chapel Hill), Stephanie M. Fullerton, Margery Gass, Nancy L. Geller, Gerardo Heiss(University of North Carolina at Chapel Hill), Barbara V. Howard, Li Hsu, Carolyn M. Hutter(Fred Hutch Cancer Center), John P. A. Ioannidis, Shuo Jiao(Fred Hutch Cancer Center), Karen Johnson, Charles Kooperberg(Fred Hutch Cancer Center), Lewis Kuller, Andrea Z. LaCroix, Kamakshi Lakshminarayan, Dorothy S. Lane, Norman L. Lasser(University of Michigan), Erin S. LeBlanc, Kuo-ping Li(University of North Carolina at Chapel Hill), Marian C. Limacher, Dan-Yu Lin(University of North Carolina at Chapel Hill), Benjamin A. Logsdon, Shari Ludlam, JoAnn E. Manson(George Washington University), Karen L. Margolis, Lisa W. Martin(George Washington University), Joan McGowan, Keri L. Monda, Jane Morley Kotchen, Lauren Nathan, Judith K. Ockene, Mary Jo O’Sullivan(University of Washington), Lawrence S. Phillips, Ross L. Prentice(University of Iowa), John Robbins, Jennifer G. Robinson(University of Iowa), Jacques E. Rossouw, Haleh Sangi‐Haghpeykar, Gloria E. Sarto, Sally A. Shumaker, Michael S. Simon, Marcia L. Stefanick(University of North Carolina at Chapel Hill), Evan A. Stein(Tougaloo College), Hua Tang, Kira C. Taylor, Cynthia A. Thomson, Timothy A. Thornton, Linda Van Horn, Mara Z. Vitolins, Jean Wactawski‐Wende, Robert W. Wallace, Sylvia Wassertheil‐Smoller(University of Washington), Donglin Zeng(University of Michigan), Deborah Applebaum‐Bowden, Michael Feolo, Weiniu Gan, Dina N. Paltoo, Phyliss Sholinsky, Anne Sturcke
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