Comparative Genomics of Trypanosomatid Parasitic Protozoa

Najib M. El-Sayed(Center for Infectious Disease Research), Peter J. Myler(Center for Infectious Disease Research), Gaëlle Blandin(Center for Infectious Disease Research), Matthew Berriman(Center for Infectious Disease Research), Jonathan Crabtree(Center for Infectious Disease Research), Gautam Aggarwal(Center for Infectious Disease Research), Elisabet Caler(Center for Infectious Disease Research), Hubert Renauld(Center for Infectious Disease Research), Elizabeth A. Worthey(Center for Infectious Disease Research), Christiane Hertz‐Fowler(Center for Infectious Disease Research), Elodie Ghedin(Center for Infectious Disease Research), Christopher S. Peacock(Center for Infectious Disease Research), Daniella Castanheira Bartholomeu(Center for Infectious Disease Research), Brian J. Haas(Center for Infectious Disease Research), Anh-Nhi Tran(Center for Infectious Disease Research), Jennifer R. Wortman(Center for Infectious Disease Research), U. Cecilia M. Alsmark(Center for Infectious Disease Research), Samuel V. Angiuoli(Center for Infectious Disease Research), Atashi Anupama(Center for Infectious Disease Research), Jonathan H. Badger(Center for Infectious Disease Research), Frédéric Bringaud(Center for Infectious Disease Research), Eithon Cadag(Center for Infectious Disease Research), Jane M. Carlton(Center for Infectious Disease Research), Gustavo Cerqueira(Center for Infectious Disease Research), Todd Creasy(Center for Infectious Disease Research), Arthur L. Delcher(Center for Infectious Disease Research), Appolinaire Djikeng(Center for Infectious Disease Research), T. Martin Embley(Center for Infectious Disease Research), Christopher R. Hauser(Center for Infectious Disease Research), Alasdair Ivens(Center for Infectious Disease Research), Sarah Kummerfeld(Center for Infectious Disease Research), José B. Pereira‐Leal(Center for Infectious Disease Research), Daniel Nilsson(Center for Infectious Disease Research), Jeremy Peterson(Center for Infectious Disease Research), Steven L. Salzberg(Center for Infectious Disease Research), Joshua M. Shallom(Center for Infectious Disease Research), Joana C. Silva(Center for Infectious Disease Research), Jaideep P. Sundaram(Center for Infectious Disease Research), Scott J Westenberger(Center for Infectious Disease Research), Owen White(Center for Infectious Disease Research), Sara E. Melville(Center for Infectious Disease Research), John E. Donelson(University of Iowa), Björn Andersson(Center for Infectious Disease Research), Kenneth Stuart(Center for Infectious Disease Research), Neil Hall(Center for Infectious Disease Research)
Science
July 14, 2005
10.1126/science.1112181
Cited by 832

Abstract

A comparison of gene content and genome architecture of Trypanosoma brucei, Trypanosoma cruzi, and Leishmania major, three related pathogens with different life cycles and disease pathology, revealed a conserved core proteome of about 6200 genes in large syntenic polycistronic gene clusters. Many species-specific genes, especially large surface antigen families, occur at nonsyntenic chromosome-internal and subtelomeric regions. Retroelements, structural RNAs, and gene family expansion are often associated with syntenic discontinuities that-along with gene divergence, acquisition and loss, and rearrangement within the syntenic regions-have shaped the genomes of each parasite. Contrary to recent reports, our analyses reveal no evidence that these species are descended from an ancestor that contained a photosynthetic endosymbiont.

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