Mapping Human Genetic Diversity in Asia
Mahmood Ameen Abdulla(University of Malaya), Ikhlak Ahmed(Central Food Technological Research Institute), Anunchai Assawamakin(National Science and Technology Development Agency), Jong Bhak(Korea Research Institute of Bioscience and Biotechnology), Samir K. Brahmachari(Central Food Technological Research Institute), Gayvelline C. Calacal(University of the Philippines System), Amit Chaurasia(Central Food Technological Research Institute), Chien-Hsiun Chen(Academia Sinica), Jieming Chen(Agency for Science, Technology and Research), Yuan-Tsong Chen(Academia Sinica), Jiayou Chu(Chinese Academy of Medical Sciences & Peking Union Medical College), Eva Maria C. Cutiongco–de la Paz(University of the Philippines System), Maria Corazon A. De Ungria(University of the Philippines System), Frederick C. Delfin(University of the Philippines System), Juli Edo(University of Malaya), Suthat Fuchareon(Mahidol University), Ho Ghang(Korea Research Institute of Bioscience and Biotechnology), Takashi Gojobori(National Institute of Advanced Industrial Science and Technology), Junsong Han, Sheng-Feng Ho(Academia Sinica), Boon‐Peng Hoh(Universiti Sains Malaysia), Wei Huang, Hidetoshi Inoko(Tokai University), Pankaj Jha(Central Food Technological Research Institute), Timothy A. Jinam(University of Malaya), Jin Li(Fudan University), Jongsun Jung, Daoroong Kangwanpong(Chiang Mai University), Jatupol Kampuansai(Chiang Mai University), Giulia C. Kennedy(Thermo Fisher Scientific (Israel)), Preeti Khurana(Central Food Technological Research Institute), Hyung Lae Kim, Kwang-Joong Kim, Sangsoo Kim(Soongsil University), Woo-Yeon Kim(Korea Research Institute of Bioscience and Biotechnology), Kuchan Kimm(Eulji University), Ryosuke Kimura(The University of Tokyo), Tomohiro Koike, Supasak Kulawonganunchai(National Science and Technology Development Agency), Vikrant Kumar(Agency for Science, Technology and Research), Poh San Lai(National University of Singapore), Jong‐Young Lee, Sunghoon Lee(Korea Research Institute of Bioscience and Biotechnology), Edison T. Liu(Agency for Science, Technology and Research), Partha P. Majumder(Indian Statistical Institute), Kiran Kumar Mandapati(Central Food Technological Research Institute), Sangkot Marzuki, Wayne Mitchell(Nanyang Technological University), Mitali Mukerji(Central Food Technological Research Institute), Kenji Naritomi(University of the Ryukyus), Chumpol Ngamphiw(National Science and Technology Development Agency), Norio Niikawa(Health Sciences University of Hokkaido), Nao Nishida(The University of Tokyo), Bermseok Oh, Sang Ho Oh(Korea Research Institute of Bioscience and Biotechnology), Jun Ohashi(The University of Tokyo), Akira Oka(Tokai University), Rick Twee‐Hee Ong(Agency for Science, Technology and Research), Carmencita D. Padilla(University of the Philippines System), Prasit Palittapongarnpim(National Science and Technology Development Agency), Henry B. Perdigon(University of the Philippines System), Maude E. Phipps(Monash University Malaysia), Eileen Png(Agency for Science, Technology and Research), Yoshiyuki Sakaki, Jazelyn M. Salvador(University of the Philippines System), Yuliana Sandraling, Vinod Scaria(Central Food Technological Research Institute), Mark Seielstad(Agency for Science, Technology and Research), Mohd Ros Sidek(Universiti Sains Malaysia), Amit Kumar Sinha(Central Food Technological Research Institute), Metawee Srikummool(Chiang Mai University), Herawati Sudoyo, Sumio Sugano(The University of Tokyo), Helena Suryadi, Yoshiyuki Suzuki, Kristina Tabbada(University of the Philippines System), Adrian Tan(Agency for Science, Technology and Research), Katsushi Tokunaga(The University of Tokyo), Sissades Tongsima(National Science and Technology Development Agency), Lilian P. Villamor(University of the Philippines System), Eric W. Wang(Thermo Fisher Scientific (Israel)), Ying Wang, Haifeng Wang, Jer-Yuarn Wu(Academia Sinica), Huasheng Xiao, Shuhua Xu, Jin Ok Yang(Korea Research Institute of Bioscience and Biotechnology), Yin Yao Shugart(National Institutes of Health), Hyang Sook Yoo(Korea Research Institute of Bioscience and Biotechnology), Wentao Yuan, Guoping Zhao, Bin Alwi Zilfalil(Universiti Sains Malaysia)
Cited by 729
Abstract
Asia harbors substantial cultural and linguistic diversity, but the geographic structure of genetic variation across the continent remains enigmatic. Here we report a large-scale survey of autosomal variation from a broad geographic sample of Asian human populations. Our results show that genetic ancestry is strongly correlated with linguistic affiliations as well as geography. Most populations show relatedness within ethnic/linguistic groups, despite prevalent gene flow among populations. More than 90% of East Asian (EA) haplotypes could be found in either Southeast Asian (SEA) or Central-South Asian (CSA) populations and show clinal structure with haplotype diversity decreasing from south to north. Furthermore, 50% of EA haplotypes were found in SEA only and 5% were found in CSA only, indicating that SEA was a major geographic source of EA populations.