Noninvasive Raman Spectroscopy in Living Mice for Evaluation of Tumor Targeting with Carbon Nanotubes
Cristina Zavaleta(Stanford University), Adam de la Zerda(Stanford University), Zhuang Liu(Stanford University), Shay Keren(Stanford University), Zhen Cheng(Stanford University), Meike L. Schipper(Stanford University), Xinyue Chen(Stanford University), Hongjie Dai(Stanford University), Sanjiv S. Gambhir(Stanford University)
Cited by 269Open Access
Abstract
An optimized noninvasive Raman microscope was used to evaluate tumor targeting and localization of single walled carbon nanotubes (SWNTs) in mice. Raman images were acquired in two groups of tumor-bearing mice. The control group received plain-SWNTs, whereas the experimental group received tumor targeting RGD-SWNTs intravenously. Raman imaging commenced over the next 72 h and revealed increased accumulation of RGD-SWNTs in tumor ( p < 0.05) as opposed to plain-SWNTs. These results support the development of a new preclinical Raman imager.
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