Human herpesvirus 6 infection associated with anticonvulsant hypersensitivity syndrome and reactive haemophagocytic syndrome

V. Descamps, F. Bouscarat(Hôpital Bichat-Claude-Bernard), S. Laglenne(Hôpital Bichat-Claude-Bernard), E. Aslangul(Hôpital Bichat-Claude-Bernard), Benoît Veber(Hôpital Bichat-Claude-Bernard), Diane Descamps(Hôpital Bichat-Claude-Bernard), J-L. SARAUX(Centre hospitalier Emile Roux), M J Grange(Hôpital Bichat-Claude-Bernard), M Grossin(Hôpital Bichat-Claude-Bernard), E Navratil(Hôpital Beaujon), B. Crickx(Hôpital Bichat-Claude-Bernard), S Bélaïch(Hôpital Bichat-Claude-Bernard)
British Journal of Dermatology
October 1, 1997
Cited by 206

Abstract

Viral infections are thought to play a part in some cutaneous drug reactions. Human herpesvirus 6 (HHV6), which is the agent of exanthema subitum (sixth disease), has never been implicated in a drug reaction. We report a patient with severe phenobarbital-induced anticonvulsant hypersensitivity syndrome in whom a fulminant haemophagocytic syndrome was associated with HHV6 infection. We discuss the possible role of HHV6 in this reactive condition.


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