Application of Fragment-Based NMR Screening, X-ray Crystallography, Structure-Based Design, and Focused Chemical Library Design to Identify Novel μM Leads for the Development of nM BACE-1 (β-Site APP Cleaving Enzyme 1) Inhibitors
Yu‐Sen Wang, Daniel F. Wyss, Michael Czarniecki(Merck & Co., Inc., Rahway, NJ, USA (United States)), Terry L. Nechuta, Eric M. Parker(University of New Hampshire), Vincent Madison, Matthew Kennedy(Merck & Co., Inc., Rahway, NJ, USA (United States)), Andrew W. Stamford(Merck & Co., Inc., Rahway, NJ, USA (United States)), William J. Greenlee, John C. Hunter, Johannes Voigt, Elizabeth M. Smith(Merck & Co., Inc., Rahway, NJ, USA (United States)), Corey Strickland(Merck & Co., Inc., Rahway, NJ, USA (United States)), Mary M. Senior, Brian M. Beyer, Brian A. McKittrick(Merck & Co., Inc., Rahway, NJ, USA (United States))
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