Design, synthesis and biological evaluation of novel 1-methyl-3-oxo-2,3,5,6,7,8-hexahydroisoquinolins as potential EZH2 inhibitors
Lidan Zhang(Sichuan University), Luoting Yu(State Key Laboratory of Biotherapy), Lifeng Zhao(Chengdu University), Ningyu Wang(Southwest Jiaotong University), Menghua Xiong(South China University of Technology), Ying Xu(Chengdu Medical College), Chao Gao(Sichuan University), Tiantao Gao(Sichuan University), Xinyu You(State Key Laboratory of Biotherapy), Qiyi Zhang(Blood Center of Zhejiang Province), Bing He(Hong Kong Baptist University), Xuejiao Song(Sichuan University), Qiang Feng(École Polytechnique Fédérale de Lausanne), Cuiting Peng(Sichuan University), Yong Luo(Sichuan University)
Cited by 20
Related Papers
Osteoclast-derived exosomal miR-214-3p inhibits osteoblastic bone formation
|Nature Communications|2016|588
Biomedical polymers: synthesis, properties, and applications
|Science China Chemistry|2022|187
Obacunone alleviates ferroptosis during lipopolysaccharide-induced acute lung injury by upregulating Nrf2-dependent antioxidant responses
|Cellular & Molecular Biology Letters|2022|170
The Anthelmintic Drug Niclosamide Induces Apoptosis, Impairs Metastasis and Reduces Immunosuppressive Cells in Breast Cancer Model
|PLoS ONE|2014|131
Design and Synthesis of EZH2-Based PROTACs to Degrade the PRC2 Complex for Targeting the Noncatalytic Activity of EZH2
|Journal of Medicinal Chemistry|2021|116