&alpha;-Glucosidase Inhibition Properties of Cucurbitane-Type Triterpene Glycosides from the Fruits of <i>Momordica charantia</i>
Nguyễn Xuân Nhiệm(Vietnam Academy of Science and Technology), Phan Văn Kiệm(Vietnam Academy of Science and Technology), Châu Văn Minh(Vietnam Academy of Science and Technology), Ninh Khắc Bản, Nguyễn Xuân Cường(Vietnam Academy of Science and Technology), Nguyễn Hữu Tùng(Chungnam National University), Lê Minh Hà(Vietnam Academy of Science and Technology), Do Thi Ha(Chungnam National University), Bùi Hữu Tài(Chungnam National University), Trần Hồng Quang(Vietnam Academy of Science and Technology), Tran Minh Ngoc(Chungnam National University), Young‐In Kwon(Food & Nutrition), Hae‐Dong Jang(Hannam University), Young Ho Kim(Chungnam National University)
Cited by 77Open Access
Abstract
Fourteen cucurbitane-type triterpene glycosides (1-14) were isolated from a methanol extract of Momordica charantia fruits, including three new compounds, charantosides A-C (1, 5, 6). Their structures were elucidated by chemical and spectroscopic methods. All isolated compounds were evaluated for alpha-glucosidase inhibitory effect. Of which, 12 and 13 showed moderate inhibitory activity against alpha-glucosidase. Whereas, 2, 3, 6-11, and 14 showed weak inhibitory activity, and 1, 4, and 5 were inactive.
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