A Role for CD5 in TCR-Mediated Signal Transduction and Thymocyte Selection
Alexander Tarakhovsky(University of Cologne), Steven B. Kanner(Bristol-Myers Squibb (United States)), Joachim Hombach(University of Zurich), Jeffrey A. Ledbetter(Bristol-Myers Squibb (United States)), Werner Müller(University of Cologne), Nigel Killeen(University of California, San Francisco), Klaus Rajewsky(University of Cologne)
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Abstract
CD5 is a transmembrane protein that is expressed on the surface of T cells and a subset of B cells. The absence of CD5 rendered thymocytes hyperresponsive to stimulation through the T cell antigen receptor (TCR) in vitro. Selection of T cells expressing three distinct transgenic TCRs was also abnormal in CD5-deficient mice. These observations indicate that CD5 can influence the fate of developing thymocytes by acting as a negative regulator of TCR-mediated signal transduction.
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