Two electron reduction of 2,3-dimethoxy-1,4-naphthoquinone metabolism in vivo prevents redox stress but interaction with the electron transport chain may be a mechanism of toxicity
Timothy W. Gant(Medical Research Council), Werner K. Lutz(University of Leicester), Toby J. Athersuch(University of Leicester), Friederike Teichert(University of Leicester), Amy Pointon(Medical Research Council), Joanne Charlwood(University of Leicester), Jonathan J. Lyon(GlaxoSmithKline (United Kingdom)), E. SHIRLEY TAYLOR(Medical Research Council), Joel D. Parry(Age UK), Ursula Lutz(University of Leicester), Hector C. Keun(Hammersmith Hospital)
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