<i>In silico</i>and<i>in vitro</i>evaluation of exonic and intronic off-target effects form a critical element of therapeutic ASO gapmer optimization
Piotr J. Kamola(GlaxoSmithKline (United Kingdom)), Joel D. Parry(Age UK), Mark R. Edbrooke(GlaxoSmithKline (United Kingdom)), Nigel J. Gooderham(Imperial College London), Aliza A. Panjwani(GlaxoSmithKline (United Kingdom)), Kenneth L. Clark(Northern Research Station), Paul A. Wilson(GlaxoSmithKline (United Kingdom)), Gaelle A. Douillard Guilloux(GlaxoSmithKline (France)), William E. Wixted(GlaxoSmithKline (United Kingdom)), Klio Maratou(GlaxoSmithKline (United Kingdom)), Kitty Moores(GlaxoSmithKline (United Kingdom)), Stephen Hughes(GlaxoSmithKline (United Kingdom)), Timothy W. Gant(Natural Environment Research Council), Linda C. Warnock(GlaxoSmithKline (United Kingdom)), Gemma Turner(GlaxoSmithKline (United Kingdom)), Emma Koppe(GlaxoSmithKline (United Kingdom)), Jeremy Kitson(GlaxoSmithKline (United Kingdom)), Sofie Eriksson(GlaxoSmithKline (United Kingdom))
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