Tumor-Selective Delivery of Macromolecular Drugs via the EPR Effect: Background and Future Prospects
Hiroshi Maeda(Kumamoto University)
Cited by 979
Related Papers
A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs.
|PubMed|1986|6.8k
Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review
|Journal of Controlled Release|2000|6.5k
The EPR effect: Unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect
|Advanced Drug Delivery Reviews|2010|3.5k
The enhanced permeability and retention (EPR) effect in tumor vasculature: the key role of tumor-selective macromolecular drug targeting
|Advances in Enzyme Regulation|2001|2.5k
The EPR effect for macromolecular drug delivery to solid tumors: Improvement of tumor uptake, lowering of systemic toxicity, and distinct tumor imaging in vivo
|Advanced Drug Delivery Reviews|2012|2.3k