PATRIC, the bacterial bioinformatics database and analysis resource

Alice R. Wattam(University of Maryland, Baltimore), David Abraham(University of Maryland, Baltimore), Oral Dalay(University of Maryland, Baltimore), Terry Disz(University of Maryland, Baltimore), Timothy Driscoll(University of Maryland, Baltimore), Joseph L. Gabbard(University of Maryland, Baltimore), Joseph J. Gillespie(University of Maryland, Baltimore), Roger Gough(University of Maryland, Baltimore), Deborah Hix(University of Maryland, Baltimore), Ronald W. Kenyon(University of Maryland, Baltimore), Dustin Machi(University of Maryland, Baltimore), Chunhong Mao(University of Maryland, Baltimore), Eric K. Nordberg(University of Maryland, Baltimore), Robert Olson(University of Maryland, Baltimore), Ross Overbeek(University of Maryland, Baltimore), Gordon D. Pusch(University of Maryland, Baltimore), Maulik Shukla(University of Maryland, Baltimore), Julie Schulman(University of Maryland, Baltimore), Rick Stevens(University of Maryland, Baltimore), Daniel E. Sullivan(University of Maryland, Baltimore), Veronika Vonstein(University of Maryland, Baltimore), Andrew Warren(University of Maryland, Baltimore), Rebecca Will(University of Maryland, Baltimore), Meredith Wilson(University of Maryland, Baltimore), Hyun Seung Yoo(University of Maryland, Baltimore), Chengdong Zhang(University of Maryland, Baltimore), Yan Zhang(University of Maryland, Baltimore), Bruno Sobral(University of Maryland, Baltimore)
Nucleic Acids Research
November 12, 2013
10.1093/nar/gkt1099
Cited by 1,339Open Access
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Abstract

The Pathosystems Resource Integration Center (PATRIC) is the all-bacterial Bioinformatics Resource Center (BRC) (http://www.patricbrc.org). A joint effort by two of the original National Institute of Allergy and Infectious Diseases-funded BRCs, PATRIC provides researchers with an online resource that stores and integrates a variety of data types [e.g. genomics, transcriptomics, protein-protein interactions (PPIs), three-dimensional protein structures and sequence typing data] and associated metadata. Datatypes are summarized for individual genomes and across taxonomic levels. All genomes in PATRIC, currently more than 10,000, are consistently annotated using RAST, the Rapid Annotations using Subsystems Technology. Summaries of different data types are also provided for individual genes, where comparisons of different annotations are available, and also include available transcriptomic data. PATRIC provides a variety of ways for researchers to find data of interest and a private workspace where they can store both genomic and gene associations, and their own private data. Both private and public data can be analyzed together using a suite of tools to perform comparative genomic or transcriptomic analysis. PATRIC also includes integrated information related to disease and PPIs. All the data and integrated analysis and visualization tools are freely available. This manuscript describes updates to the PATRIC since its initial report in the 2007 NAR Database Issue.

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