Neocortical neurogenesis in humans is restricted to development
Ratan D. Bhardwaj(Karolinska Institutet), Maurice A. Curtis(Salk Institute for Biological Studies), Kirsty L. Spalding(Nobel Foundation), Bruce A. Buchholz(Lawrence Livermore National Laboratory), David Fink(Australian Nuclear Science and Technology Organisation), Thomas Björk‐Eriksson(Yale University), Claes Nordborg(Sahlgrenska University Hospital), Fred H. Gage(Salk Institute for Biological Studies), Henrik Druid(Lawrence Livermore National Laboratory), Peter S. Eriksson(Lawrence Livermore National Laboratory), Jonas Frisén(Lawrence Livermore National Laboratory)
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Abstract
Stem cells generate neurons in discrete regions in the postnatal mammalian brain. However, the extent of neurogenesis in the adult human brain has been difficult to establish. We have taken advantage of the integration of (14)C, generated by nuclear bomb tests during the Cold War, in DNA to establish the age of neurons in the major areas of the human cerebral neocortex. Together with the analysis of the neocortex from patients who received BrdU, which integrates in the DNA of dividing cells, our results demonstrate that, whereas nonneuronal cells turn over, neurons in the human cerebral neocortex are not generated in adulthood at detectable levels but are generated perinatally.
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