Discovery of (+)-N-(3-Aminopropyl)-N-[1-(5-benzyl-3-methyl-4-oxo-[1,2]thiazolo[5,4-d]pyrimidin-6-yl)-2-methylpropyl]-4-methylbenzamide (AZD4877), a Kinesin Spindle Protein Inhibitor and Potential Anticancer Agent

Maria‐Elena Theoclitou(AstraZeneca (United Kingdom)), Xiaolan Zheng(AstraZeneca (United States)), Lillian Castriotta(AstraZeneca (United States)), Timothy Pontz(AstraZeneca (United States)), Sandra Filla(AstraZeneca (United States)), Ellen Freed(Memorial Sloan Kettering Cancer Center), Dennis Huszar(Millennium Engineering and Integration (United States)), Tracy L. Deegan(AstraZeneca (United States)), Maniyan P. Padmanilayam(AstraZeneca (United Kingdom)), Patrick Brassil(AstraZeneca (United States)), Brian Aquila(AstraZeneca (United States)), Ezhuthachan Jayachandran(AstraZeneca (United States)), Muthusamy Jayaraman(Forma Therapeutics (United States)), Daniel Russell(AstraZeneca (United States)), David Whitston(AstraZeneca (United States)), Audrey M. Davies(AstraZeneca (United States)), Erin Code(AstraZeneca (United States)), Deborah Lawson(AstraZeneca (United States)), Paula Lewis, Haiqing Hu(AstraZeneca (United States)), Murali V.P. Nadella(AstraZeneca (South Korea)), Vibha Oza(AstraZeneca (United States)), Lucienne Ronco(Ontario Genomics), Michael P. Collins(Io Therapeutics (United States))

Journal of Medicinal Chemistry

September 7, 2011

Cited by 44

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Discovery of (+)-<i>N</i>-(3-Aminopropyl)-<i>N</i>-[1-(5-benzyl-3-methyl-4-oxo-[1,2]thiazolo[5,4-<i>d</i>]pyrimidin-6-yl)-2-methylpropyl]-4-methylbenzamide (AZD4877), a Kinesin Spindle Protein Inhibitor and Potential Anticancer Agent