Leaderboards/Sirtuins and Resveratrol in Medicine

Sirtuins and Resveratrol in Medicine

Last updated July 15, 2026

Rising Stars

Fresh ink, massive impact

Researchers

1
Jing Jin
University of Science and Technology of China
2
Matthew D. Figley
Washington University in St. Louis
3
Jiaxin Deng
Chengdu Sport University
4
Rabia R. Khawaja
Albert Einstein College of Medicine
5
Runhua Du
Chinese Academy of Sciences
6
Hui-ru Li
Hunan University
7
Helena A. K. Lapatto
University of Helsinki
8
Qi‐Hang Zhao
Nanchang University
9
Yasser Majeed
Carnegie Mellon University Qatar
10
Asael Roichman
Princeton University

Papers

1
Publication in Biomedicine & Pharmacotherapy (2024) [115 citations, W4392266553]
Biomedicine & Pharmacotherapy|2024
115 cit.
2
Sirtuin 1/sirtuin 3 are robust lysine delactylases and sirtuin 1-mediated delactylation regulates glycolysis
iScience|2024
103 cit.
3
Publication in Nature Aging (2025) [35 citations, W4407150820]
Nature Aging|2025
35 cit.
4
Microbiome metabolism of dietary phytochemicals controls the anticancer activity of PI3K inhibitors
Cell|2025
26 cit.
5
Publication in Frontiers in Public Health (2024) [16 citations, W4403079596]
Frontiers in Public Health|2024
16 cit.
6
Publication in Nature Cell Biology (2025) [10 citations, W4415143512]
Nature Cell Biology|2025
10 cit.
7
Dietary Fiber Lacks a Consistent Effect on Immune Checkpoint Blockade Efficacy Across Diverse Murine Tumor Models
Cancer Research|2025
8 cit.
8
Publication in BMC Pediatrics (2025) [2 citations, W4415943985]
BMC Pediatrics|2025
2 cit.
9
Publication (2025) [W4413905548]
Unknown Journal|2025
0 cit.
10
Publication (2025) [W4413905566]
Unknown Journal|2025
0 cit.

Emerging Leaders

Drafting the new consensus

Researchers

1
Keir J. Menzies
University of Ottawa
2
Xiaoyang Su
Rutgers, The State University of New Jersey
3
Di Zhang
Shandong University of Technology
4
Sama F. Sleiman
Lebanese American University
5
Ivana Novak
University of Split
6
Zhixun Dou
Université Paris-Saclay
7
Xiaoqing Wang
Roche (China)
8
Lindsay E. Wu
UNSW Sydney
9
Cynthia Tannous
Centre National de la Recherche Scientifique
10
Shanping He
Hunan Normal University

Papers

1
Lysine l-lactylation is the dominant lactylation isomer induced by glycolysis
Nature Chemical Biology|2024
140 cit.
2
Upregulation of PD-L1 in Senescence and Aging
Molecular and Cellular Biology|2022
122 cit.
3
Host–microbiome interactions in nicotinamide mononucleotide (NMN) deamidation
FEBS Letters|2023
27 cit.
4
Tannic acid attenuates intestinal oxidative damage by improving antioxidant capacity and intestinal barrier in weaned piglets and IPEC-J2 cells
Frontiers in Nutrition|2022
21 cit.
5
WSTF nuclear autophagy regulates chronic but not acute inflammation
Nature|2025
16 cit.
6
Nicotinamide Riboside Supplementation Restores Myocardial Nicotinamide Adenine Dinucleotide Levels, Improves Survival, and Promotes Protective Environment Post Myocardial Infarction
Cardiovascular Drugs and Therapy|2023
13 cit.
7
Fertility protection during chemotherapy treatment by boosting the NAD(P)+ metabolome
EMBO Molecular Medicine|2024
13 cit.
8
Stable isotope tracing reveals compartmentalized nitrogen assimilation in scleractinian corals
Frontiers in Marine Science|2022
11 cit.
9
Oleic and linoleic acids promote chondrocyte apoptosis by inhibiting autophagy via downregulation of SIRT1/FOXO1 signaling
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease|2024
10 cit.
10
HDAC1 promotes basal autophagy and proliferation of colorectal cancer cells by mediating ATG16L1 deacetylation
Biochemical and Biophysical Research Communications|2024
8 cit.

Current Senior Leaders

Wrote the book, still writing it

Researchers

1
David Sinclair
Center for Human Genetics
2
Leonard Guarente
Lifespan
3
Johan Auwerx
École Polytechnique Fédérale de Lausanne
4
Eric Verdin
Buck Institute for Research on Aging
5
Nihal Ahmad
University of Wisconsin–Madison
6
Rafael de Cabo
National Institute on Aging
7
John M. Denu
University of Wisconsin System
8
Shin‐ichiro Imai
Washington University in St. Louis
9
Yingming Zhao
May Institute
10
Pere Puigserver
Harvard University

Papers

1
Dose translation from animal to human studies revisited
The FASEB Journal|2007
6.3k cit.
2
Resveratrol improves health and survival of mice on a high-calorie diet
Nature|2006
4.2k cit.
3
Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1α
Cell|2006
4k cit.
4
Metabolic regulation of gene expression by histone lactylation
Nature|2019
3.9k cit.
5
A Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis
Cell|1998
3.8k cit.
6
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
Nature|2003
3.8k cit.
7
Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
Nature|2000
3.5k cit.
8
AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
Nature|2009
3.2k cit.
9
Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1
Nature|2005
3.1k cit.
10
The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms
Genes & Development|1999
2.3k cit.

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