Leaderboards/RNA modifications and cancer

RNA modifications and cancer

Last updated July 15, 2026

Rising Stars

Fresh ink, massive impact

Researchers

1
Jaime A. Castro-Mondragón
Inserm
2
Eliza Yankova
Wellcome/MRC Cambridge Stem Cell Institute
3
Netanel Loyfer
Hebrew University of Jerusalem
4
Zhaonan Zou
Kumamoto University
5
Jia Xiong
Zhejiang University
6
Baiyu Qiu
Columbia University
7
Botai Li
Chinese Academy of Sciences
8
Pietro Boccaletto
International Institute of Molecular and Cell Biology
9
Florêncio Porto Freitas
University of Würzburg
10
Andrea Cappannini
International Institute of Molecular and Cell Biology

Papers

1
Phospholipids with two polyunsaturated fatty acyl tails promote ferroptosis
Cell|2024
351 cit.
2
7-Dehydrocholesterol is an endogenous suppressor of ferroptosis
Nature|2024
305 cit.
3
ChIP-Atlas 3.0: a data-mining suite to explore chromosome architecture together with large-scale regulome data
Nucleic Acids Research|2024
185 cit.
4
Fatal COVID-19 pulmonary disease involves ferroptosis
Nature Communications|2024
51 cit.
5
<i>wgbstools</i> : a computational suite for DNA methylation sequencing data analysis
Life Science Alliance|2026
2 cit.
6
Abstract 1768: Pharmacological inhibition of METTL1 as a novel therapeutic strategy against aggressive malignancies
Cancer Research|2025
0 cit.
7
Publication in bioRxiv (Cold Spring Harbor Laboratory) (2026) [W7141366989]
bioRxiv (Cold Spring Harbor Laboratory)|2026
0 cit.
8
Publication in Cancer Letters (2026) [W7143376854]
Cancer Letters|2026
0 cit.
9
ChIP-Atlas 2025 update: 10-year anniversary of a data-mining platform for exploring epigenomic landscape
Nucleic Acids Research|2026
0 cit.
10
Publication in Cancer Immunology Research (2026) [W7165028562]
Cancer Immunology Research|2026
0 cit.

Emerging Leaders

Drafting the new consensus

Researchers

1
Anthony Mathelier
Oslo University Hospital
2
Mallar Bhattacharya
University of California, San Francisco
3
Kyle Kai‐How Farh
Illumina (United States)
4
Patricia P. Chan
University of California, Santa Cruz
5
Schraga Schwartz
Weizmann Institute of Science
6
Shuibin Lin
Sun Yat-sen University
7
J.L. Hansen
Washington University in St. Louis
8
Huai‐Qiang Ju
Sun Yat-sen University
9
Eva Maria Novoa
Garvan Institute of Medical Research
10
Konstantinos Tzelepis
Wellcome/MRC Cambridge Stem Cell Institute

Papers

1
JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles
Nucleic Acids Research|2023
1k cit.
2
Quantitative analysis of tRNA abundance and modifications by nanopore RNA sequencing
Nature Biotechnology|2023
223 cit.
3
Methionine deficiency facilitates antitumour immunity by altering m<sup>6</sup>A methylation of immune checkpoint transcripts
Gut|2022
215 cit.
4
Exclusion of m6A from splice-site proximal regions by the exon junction complex dictates m6A topologies and mRNA stability
Molecular Cell|2023
201 cit.
5
N7-methylguanosine tRNA modification promotes esophageal squamous cell carcinoma tumorigenesis via the RPTOR/ULK1/autophagy axis
Nature Communications|2022
181 cit.
6
The landscape of tolerated genetic variation in humans and primates
Science|2023
177 cit.
7
N6-methyladenosine (m6A) in 18S rRNA promotes fatty acid metabolism and oncogenic transformation
Nature Metabolism|2022
141 cit.
8
Identification of constrained sequence elements across 239 primate genomes
Nature|2023
113 cit.
9
Long-read sequencing in the era of epigenomics and epitranscriptomics
Nature Methods|2023
95 cit.
10
Targeting tumour-intrinsic N <sup>7</sup> -methylguanosine tRNA modification inhibits MDSC recruitment and improves anti-PD-1 efficacy
Gut|2022
81 cit.

Current Senior Leaders

Wrote the book, still writing it

Researchers

1
Simon Anders
European Molecular Biology Laboratory
2
Steven L. Salzberg
Johns Hopkins University
3
Chuan He
University of Chicago
4
Jill P. Mesirov
University of California San Diego
5
Lior Pachter
California Institute of Technology
6
Frank Oliver Glöckner
Alfred-Wegener-Institut Helmholtz-Zentrum für Polar- und Meeresforschung
7
Aviv Regev
Broad Institute
8
Howard Y. Chang
Stanford University
9
Gideon Dreyfuss
University of Pennsylvania
10
Harry F. Noller
University of California, Santa Cruz

Papers

1
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
Genome biology|2014
100.5k cit.
2
Fast gapped-read alignment with Bowtie 2
Nature Methods|2012
61.1k cit.
3
Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles
Proceedings of the National Academy of Sciences|2005
56.7k cit.
4
The SILVA ribosomal RNA gene database project: improved data processing and web-based tools
Nucleic Acids Research|2012
34k cit.
5
HISAT: a fast spliced aligner with low memory requirements
Nature Methods|2015
26.1k cit.
6
Ultrafast and memory-efficient alignment of short DNA sequences to the human genome
Genome biology|2009
23k cit.
7
HTSeq—a Python framework to work with high-throughput sequencing data
Bioinformatics|2014
22.7k cit.
8
Full-length transcriptome assembly from RNA-Seq data without a reference genome
Nature Biotechnology|2011
22.6k cit.
9
Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation
Nature Biotechnology|2010
16.5k cit.
10
Differential expression analysis for sequence count data
Genome biology|2010
16.4k cit.

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