Leaderboards/Peroxisome Proliferator-Activated Receptors

Peroxisome Proliferator-Activated Receptors

Last updated July 15, 2026

Rising Stars

Fresh ink, massive impact

Researchers

1
Michael S. Haney
Neurosciences Institute
2
Junliang Kuang
Shanghai Sixth People's Hospital
3
Guoyuan Qi
University of Arizona
4
Qing Zeng
Southern Medical University
5
Michal K. Handzlik
Salk Institute for Biological Studies
6
Mengdie Dong
Nantong University
7
Yongjian Hu
Jinggangshan University
8
Ju-Qiong Wang
Yonsei University
9
Zhending Gan
South China Agricultural University
10
Nikos Koundouros
Cornell University

Papers

1
APOE4/4 is linked to damaging lipid droplets in Alzheimer’s disease microglia
Nature|2024
474 cit.
2
Lipids and lipid metabolism in cellular senescence: Emerging targets for age-related diseases
Ageing Research Reviews|2024
152 cit.
3
Publication in Science (2025) [34 citations, W4408388856]
Science|2025
34 cit.
4
Investigating regional-specific gut microbial distribution: an uncharted territory in disease therapeutics
Protein & Cell|2024
4 cit.
5
Identification of the Saga Complex As a Key Regulator of Hematopoiesis
Blood|2024
0 cit.

Emerging Leaders

Drafting the new consensus

Researchers

1
Shaun Conway
Unknown
2
Irfan J. Lodhi
Washington University in St. Louis
3
Huai‐Qiang Ju
Sun Yat-sen University
4
Jurre J. Kamphorst
AstraZeneca (Brazil)
5
Xiangjian Luo
Central South University
6
Julieta Alfonso
The Nature Conservancy
7
Tsuyoshi Osawa
The University of Tokyo
8
Gregory Louie
Duke University
9
Priyanka Baloni
Purdue University West Lafayette
10
Chao Ran
Feed Research Institute

Papers

1
Methionine deficiency facilitates antitumour immunity by altering m<sup>6</sup>A methylation of immune checkpoint transcripts
Gut|2022
215 cit.
2
Acyl-CoA synthetase long-chain 3-mediated fatty acid oxidation is required for TGFβ1-induced epithelial-mesenchymal transition and metastasis of colorectal carcinoma
International Journal of Biological Sciences|2022
109 cit.
3
Multi-Omic analyses characterize the ceramide/sphingomyelin pathway as a therapeutic target in Alzheimer’s disease
Communications Biology|2022
104 cit.
4
Liver ACOX1 regulates levels of circulating lipids that promote metabolic health through adipose remodeling
Nature Communications|2024
73 cit.
5
The liver microenvironment orchestrates FGL1-mediated immune escape and progression of metastatic colorectal cancer
Nature Communications|2023
62 cit.
6
The Macrophage-Associated LncRNA <i>MALR</i> Facilitates ILF3 Liquid–Liquid Phase Separation to Promote HIF1α Signaling in Esophageal Cancer
Cancer Research|2022
58 cit.
7
Arginine methylation of MTHFD1 by PRMT5 enhances anoikis resistance and cancer metastasis
Oncogene|2022
43 cit.
8
PGC1α-mediated fatty acid oxidation promotes TGFβ1-induced epithelial-mesenchymal transition and metastasis of nasopharyngeal carcinoma
Life Sciences|2022
40 cit.
9
Construction of exosome non-coding RNA feature for non-invasive, early detection of gastric cancer patients by machine learning: a multi-cohort study
Gut|2025
40 cit.
10
TMEM135 links peroxisomes to the regulation of brown fat mitochondrial fission and energy homeostasis
Nature Communications|2023
37 cit.

Current Senior Leaders

Wrote the book, still writing it

Researchers

1
Bruce M. Spiegelman
Dana-Farber Cancer Institute
2
Ronald M. Evans
University of California San Diego
3
Johan Auwerx
École Polytechnique Fédérale de Lausanne
4
Bart Staels
Inserm
5
Daniel P. Kelly
Cardiovascular Institute of the South
6
Walter Wahli
École Nationale Vétérinaire de Toulouse
7
Christopher K. Glass
University of California San Diego
8
Hong Chen
Ningxia Medical University
9
Frank J. Gonzalez
National Cancer Institute
10
Peter Tontonoz
University of California, Los Angeles

Papers

1
Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities
Molecular Cell|2010
14.6k cit.
2
Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance
Science|1993
7.5k cit.
3
Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
Journal of Clinical Investigation|2003
5.8k cit.
4
Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
Journal of Clinical Investigation|2003
5.7k cit.
5
A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis
Nature|2012
4.7k cit.
6
Mechanisms Controlling Mitochondrial Biogenesis and Respiration through the Thermogenic Coactivator PGC-1
Cell|1999
4.1k cit.
7
Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1α
Cell|2006
4k cit.
8
A Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis
Cell|1998
3.8k cit.
9
Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor
Cell|1994
3.5k cit.
10
The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation
Nature|1998
3.5k cit.

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