A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

Pontus Boström(Harvard University), Jun Wu(Dana-Farber Cancer Institute), Mark P. Jedrychowski(Harvard University), Anisha Korde(Harvard University), Li Ye(Dana-Farber Cancer Institute), James C. Lo(Dana-Farber Cancer Institute), Kyle A. Rasbach(Harvard University), Elisabeth A. Boström(Brigham and Women's Hospital), Jang Hyun Choi(Harvard University), Jonathan Z. Long(Harvard University), Shingo Kajimura(University of California, San Francisco), Maria Cristina Zingaretti(Marche Polytechnic University), Birgitte F. Vind(Odense University Hospital), Hua Tu(LakePharma (United States)), Saverio Cinti(Marche Polytechnic University), Kurt Højlund(Odense University Hospital), Steven P. Gygi(Harvard University), Bruce M. Spiegelman(Harvard University)
Nature
January 1, 2012
10.1038/nature10777
Cited by 4,682Open Access
Full Text

Abstract

Related Papers

A Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis
Pere Puigserver, Zhidan Wu, Cheol Won Park et al.|Cell|1998|3.8k
Locating proteins in the cell using TargetP, SignalP and related tools
Olof Emanuelsson, Søren Brunak, Gunnar von Heijne et al.|Nature Protocols|2007|3.2k
New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure
Yu‐Hua Tseng, Efi Kokkotou, Tim J. Schulz et al.|Nature|2008|1.1k
The role of exercise and PGC1α in inflammation and chronic disease
Christoph Handschin, Bruce M. Spiegelman|Nature|2008|1.1k
PGC-1α protects skeletal muscle from atrophy by suppressing FoxO3 action and atrophy-specific gene transcription
Marco Sandri, Jiandie D. Lin, Christoph Handschin et al.|Proceedings of the National Academy of Sciences|2006|965