Leaderboards/Liver physiology and pathology

Liver physiology and pathology

Last updated July 15, 2026

Rising Stars

Fresh ink, massive impact

Researchers

1
Sonakshi Bhattacharjee
AiCuris (Germany)
2
Federico F. De Ponti
VIB-UGent Center for Inflammation Research
3
Paulina Núñez Bernal
Heidelberg University
4
Shahrbanoo Keshavarz Azizi Raftar
University of California, San Francisco
5
Yu Miyamoto
The University of Osaka
6
Shani Ben‐Moshe
Max Planck Institute of Biochemistry
7
Yuzo Koda
Keio University
8
María del Mar Rigual
Spanish National Cancer Research Centre
9
Flavio Bonanini
Mimetas (Netherlands)
10
Shikai Hu
Chinese Academy of Medical Sciences & Peking Union Medical College

Papers

1
Periportal macrophages protect against commensal-driven liver inflammation
Nature|2024
112 cit.
2
A microvascularized in vitro liver model for disease modeling and drug discovery
Biofabrication|2024
19 cit.
3
A comparison between different human hepatocyte models reveals profound differences in net glucose production, lipid composition and metabolism in vitro
Experimental Cell Research|2024
10 cit.
4
Dancing with disorder: chorea – an unusual and neglected manifestation of antiphospholipid syndrome
Lupus Science & Medicine|2024
1 cit.
5
Abstract 1218: A comprehensive and scalable human liver-on-a-chip model forfibrosis drug discovery and gene delivery applications
Cancer Research|2025
1 cit.
6
Abstract 4199: Comprehensive 3D liver cancer model to study the tumor microenvironment for therapy development
Cancer Research|2024
0 cit.
7
OS-054 CD8+ tissue-resident memory T cells promotes liver fibrosis resolution and are regulated by intestinal microbiota
Journal of Hepatology|2025
0 cit.
8
NOVEL AUTOANTIBODIES IDENTIFIED IN THE ANTIPHOSPHOLIPID SYNDROME
The Journal of Rheumatology|2025
0 cit.

Emerging Leaders

Drafting the new consensus

Researchers

1
Meritxell Huch
Center for Systems Biology Dresden
2
Mathew J. Garnett
Wellcome Sanger Institute
3
Dominic Grün
University of Würzburg
4
Myung Jin Son
Korea Research Institute of Bioscience and Biotechnology
5
Leila Akkari
Oncode Institute
6
S. Tamir Rashid
Imperial College London
7
Yunfang Wang
Beijing Tsinghua Chang Gung Hospital
8
Ludi Zhang
Hebei Medical University
9
Enis Kostallari
Mayo Clinic in Arizona
10
Albert Gough
University of Pittsburgh

Papers

1
Macrophage-mediated myelin recycling fuels brain cancer malignancy
Cell|2024
187 cit.
2
CD103+ regulatory T cells underlie resistance to radio-immunotherapy and impair CD8+ T cell activation in glioblastoma
Nature Cancer|2023
98 cit.
3
RNF43/ZNRF3 loss predisposes to hepatocellular-carcinoma by impairing liver regeneration and altering the liver lipid metabolic ground-state
Nature Communications|2022
70 cit.
4
A multicellular liver organoid model for investigating hepatitis C virus infection and nonalcoholic fatty liver disease progression
Hepatology|2023
39 cit.
5
Region-specific cellular and molecular basis of liver regeneration after acute pericentral injury
Cell stem cell|2024
38 cit.
6
Cancer cell genetics shaping of the tumor microenvironment reveals myeloid cell-centric exploitable vulnerabilities in hepatocellular carcinoma
Nature Communications|2024
35 cit.
7
Mouse liver assembloids model periportal architecture and biliary fibrosis
Nature|2025
32 cit.
8
Glycolysis in hepatic stellate cells coordinates fibrogenic extracellular vesicle release spatially to amplify liver fibrosis
Science Advances|2024
30 cit.
9
RGD density along with substrate stiffness regulate hPSC hepatocyte functionality through YAP signalling
Biomaterials|2022
26 cit.
10
VarID2 quantifies gene expression noise dynamics and unveils functional heterogeneity of ageing hematopoietic stem cells
Genome biology|2023
26 cit.

Current Senior Leaders

Wrote the book, still writing it

Researchers

1
Hans Clevers
Hubrecht Institute for Developmental Biology and Stem Cell Research
2
Paolo M. Comoglio
IFOM
3
George K. Michalopoulos
University of Pittsburgh
4
David A. Brenner
Institute of Medical Microbiology and Hygiene
5
Markus Grompe
Oregon Health & Science University
6
Robert F. Schwabe
Columbia University
7
Anna Mae Diehl
Duke Medical Center
8
Rebecca Taub
Madrigal Pharmaceuticals (United States)
9
Martin L. Yarmush
Rutgers, The State University of New Jersey
10
Frank Tacke
Charité - Universitätsmedizin Berlin

Papers

1
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche
Nature|2009
7.2k cit.
2
Identification of stem cells in small intestine and colon by marker gene Lgr5
Nature|2007
5.7k cit.
3
EASL 2017 Clinical Practice Guidelines on the management of hepatitis B virus infection
Journal of Hepatology|2017
5.4k cit.
4
Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium
Gastroenterology|2011
3.8k cit.
5
Constitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC <sup>−/−</sup> Colon Carcinoma
Science|1997
3.3k cit.
6
Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts
Nature|2010
2.5k cit.
7
Prospective Derivation of a Living Organoid Biobank of Colorectal Cancer Patients
Cell|2015
2.4k cit.
8
Purified hematopoietic stem cells can differentiate into hepatocytes in vivo
Nature Medicine|2000
2.3k cit.
9
Crypt stem cells as the cells-of-origin of intestinal cancer
Nature|2008
2.2k cit.
10
The β-Catenin/TCF-4 Complex Imposes a Crypt Progenitor Phenotype on Colorectal Cancer Cells
Cell|2002
2k cit.

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