Leaderboards/Inflammation biomarkers and pathways

Inflammation biomarkers and pathways

Last updated July 15, 2026

Rising Stars

Fresh ink, massive impact

Papers

Identification of senescent, TREM2-expressing microglia in aging and Alzheimer’s disease model mouse brain

Nature Neuroscience|2024

151 cit.

Lemborexant ameliorates tau-mediated sleep loss and neurodegeneration in males in a mouse model of tauopathy

Nature Neuroscience|2025

14 cit.

Bulk and single-cell RNA sequencing analysis with 101 machine learning combinations reveal neutrophil extracellular trap involvement in hepatic ischemia-reperfusion injury and early allograft dysfunction

International Immunopharmacology|2024

10 cit.

Rod-shaped microglia interact with neuronal dendrites to attenuate cortical excitability during TDP-43-related neurodegeneration

Immunity|2025

10 cit.

Lemborexant, a Dual Orexin Receptor Antagonist, ameliorates Tau‐mediated Sleep Loss and Neurodegeneration

Alzheimer s & Dementia|2024

1 cit.

Publication in Journal of Translational Medicine (2026) [W7155491648]

Journal of Translational Medicine|2026

0 cit.

Emerging Leaders

Drafting the new consensus

Researchers

Kathryn M. Monroe

Denali Therapeutics (United States)

Tina Schwabe

Alector (United States)

Ilaria Tassi

Alector (United States)

Nicolai Franzmeier

LMU Klinikum

Marc Suárez‐Calvet

Pasqual Maragall Foundation

Shilpa Sambashivan

Sana Biotechnology (United States)

Fabia Filipello

IRCCS Humanitas Research Hospital

Francesca Cignarella

Alector (United States)

Wen Sun

University of Science and Technology of China

Laralynne Przybyla

University of California, San Francisco

Papers

Plasma and CSF biomarkers in a memory clinic: Head‐to‐head comparison of phosphorylated tau immunoassays

Alzheimer s & Dementia|2022

224 cit.

A TREM2-activating antibody with a blood–brain barrier transport vehicle enhances microglial metabolism in Alzheimer’s disease models

Nature Neuroscience|2023

222 cit.

Tau deposition patterns are associated with functional connectivity in primary tauopathies

Nature Communications|2022

108 cit.

Earlier Alzheimer’s disease onset is associated with tau pathology in brain hub regions and facilitated tau spreading

Nature Communications|2022

87 cit.

Amyloid-associated hyperconnectivity drives tau spread across connected brain regions in Alzheimer’s disease

Science Translational Medicine|2025

74 cit.

Defects in lysosomal function and lipid metabolism in human microglia harboring a TREM2 loss of function mutation

Acta Neuropathologica|2023

70 cit.

ApoE4 and Connectivity-Mediated Spreading of Tau Pathology at Lower Amyloid Levels

JAMA Neurology|2023

67 cit.

Uncompetitive, adduct-forming SARM1 inhibitors are neuroprotective in preclinical models of nerve injury and disease

Neuron|2022

65 cit.

Elevated CSF GAP-43 is associated with accelerated tau accumulation and spread in Alzheimer’s disease

Nature Communications|2024

52 cit.

Alpha synuclein co-pathology is associated with accelerated amyloid-driven tau accumulation in Alzheimer’s disease

Molecular Neurodegeneration|2025

41 cit.

Current Senior Leaders

Wrote the book, still writing it

Researchers

Marco Colonna

Washington University in St. Louis

Anthony Cerami

Araim Pharmaceuticals (United States)

Christian Haass

German Center for Neurodegenerative Diseases

Oleg Butovsky

Brigham and Women's Hospital

Howard L. Weiner

Baylor College of Medicine

David M. Holtzman

Hope Center for Neurological Disorders

Guojun Bu

Hong Kong University of Science and Technology

John Ziebuhr

Justus-Liebig-Universität Gießen

Joachim L. Schultze

German Center for Neurodegenerative Diseases

Oliver Stegle

German Cancer Research Center

Papers

The species Severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2

Nature Microbiology|2020

7.7k cit.

The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases

Immunity|2017

3k cit.

Identification of a unique TGF-β–dependent molecular and functional signature in microglia

Nature Neuroscience|2013

2.6k cit.

Shock and Tissue Injury Induced by Recombinant Human Cachectin

Science|1986

2.6k cit.

Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia

Nature|1987

2.5k cit.

Passive Immunization Against Cachectin/Tumor Necrosis Factor Protects Mice from Lethal Effect of Endotoxin

Science|1985

2.4k cit.

Transcriptome-Based Network Analysis Reveals a Spectrum Model of Human Macrophage Activation

Immunity|2014

2.2k cit.

Regulatory T Cell Clones Induced by Oral Tolerance: Suppression of Autoimmune Encephalomyelitis

Science|1994

2k cit.

Amyloid β-peptide is produced by cultured cells during normal metabolism

Nature|1992

1.9k cit.

Control of Treg and TH17 cell differentiation by the aryl hydrocarbon receptor

Nature|2008

1.8k cit.

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