The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases

Susanne Krasemann; Charlotte Madore; Ron Cialic; Caroline Baufeld; Narghes Calcagno; Rachid El Fatimy; Lien Beckers; Elaine O’Loughlin; Yang Xu; Zain Fanek; David Greco; Scott Smith; George Tweet; Zachary Humulock; Tobias Zrzavy; Patricia Conde-Sanroman; Mar Gacias; Zhiping Weng; Hao Chen; Emily Tjon; Fargol Mazaheri; Kristin Hartmann; Asaf Madi; Jason D. Ulrich; Markus Glatzel; Anna Worthmann; Jöerg Heeren; Bogdan Budnik; Cynthia A. Lemere; Tsuneya Ikezu; Frank L. Heppner; Vladimir Litvak; David M. Holtzman; Hans Lassmann; Howard L. Weiner; Jordi Ochando; Christian Haass; Oleg Butovsky

doi:10.1016/j.immuni.2017.08.008

The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases

Susanne Krasemann(Brigham and Women's Hospital), Charlotte Madore(Brigham and Women's Hospital), Ron Cialic(Brigham and Women's Hospital), Caroline Baufeld(Brigham and Women's Hospital), Narghes Calcagno(Brigham and Women's Hospital), Rachid El Fatimy(Brigham and Women's Hospital), Lien Beckers(Brigham and Women's Hospital), Elaine O’Loughlin(Brigham and Women's Hospital), Yang Xu(University of Massachusetts Chan Medical School), Zain Fanek(Brigham and Women's Hospital), David Greco(Brigham and Women's Hospital), Scott Smith(Brigham and Women's Hospital), George Tweet(Brigham and Women's Hospital), Zachary Humulock(Brigham and Women's Hospital), Tobias Zrzavy(Medical University of Vienna), Patricia Conde-Sanroman(Icahn School of Medicine at Mount Sinai), Mar Gacias(Icahn School of Medicine at Mount Sinai), Zhiping Weng(University of Massachusetts Chan Medical School), Hao Chen(University of Massachusetts Chan Medical School), Emily Tjon(Brigham and Women's Hospital), Fargol Mazaheri(German Center for Neurodegenerative Diseases), Kristin Hartmann(Universität Hamburg), Asaf Madi(Brigham and Women's Hospital), Jason D. Ulrich(Hope Center for Neurological Disorders), Markus Glatzel(Universität Hamburg), Anna Worthmann(Universität Hamburg), Jöerg Heeren(Universität Hamburg), Bogdan Budnik(Harvard University), Cynthia A. Lemere(Brigham and Women's Hospital), Tsuneya Ikezu(Boston University), Frank L. Heppner(Charité - Universitätsmedizin Berlin), Vladimir Litvak(University of Massachusetts Chan Medical School), David M. Holtzman(Hope Center for Neurological Disorders), Hans Lassmann(Medical University of Vienna), Howard L. Weiner(Brigham and Women's Hospital), Jordi Ochando(Icahn School of Medicine at Mount Sinai), Christian Haass(German Center for Neurodegenerative Diseases), Oleg Butovsky(Brigham and Women's Hospital)

Immunity

September 1, 2017

10.1016/j.immuni.2017.08.008

Cited by 3,009Open Access

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