Leaderboards/Inflammasome and immune disorders

Inflammasome and immune disorders

Last updated July 15, 2026

Rising Stars

Fresh ink, massive impact

Researchers

1
Hongxu Xian
National University of Singapore
2
Alhamdu Adamu
Shanxi Medical University
3
Juan Ignacio Jiménez‐Loygorri
National Research Council
4
Alva M. Casey
University of Cambridge
5
Chi G. Weindel
Texas A&M Health Science Center
6
Jun Li
Second Affiliated Hospital of Zhejiang University
7
Inga V. Hochheiser
University of Bonn
8
Arumugam Balasubramanian
Harvard University
9
Alex G. Johnson
Harvard University
10
Yuanyuan Wei
Second Affiliated Hospital of Zhejiang University

Papers

1
The role of neuroinflammation in neurodegenerative diseases: current understanding and future therapeutic targets
Frontiers in Aging Neuroscience|2024
427 cit.
2
Mitophagy curtails cytosolic mtDNA-dependent activation of cGAS/STING inflammation during aging
Nature Communications|2024
289 cit.
3
The palmitoylation of gasdermin D directs its membrane translocation and pore formation during pyroptosis
Science Immunology|2024
177 cit.
4
Publication in Nature Metabolism (2025) [99 citations, W4407752013]
Nature Metabolism|2025
99 cit.
5
Structure and assembly of a bacterial gasdermin pore
Nature|2024
41 cit.
6
Urolithin A promotes p62-dependent lysophagy to prevent acute retinal neurodegeneration
Molecular Neurodegeneration|2024
24 cit.
7
Aging STINGs: mitophagy at the crossroads of neuroinflammation
Autophagy|2024
21 cit.
8
Mitochondrial DNA oxidation propagates autoimmunity by enabling plasmacytoid dendritic cells to induce TFH differentiation
Nature Immunology|2025
14 cit.
9
Recycling the recyclers: lysophagy emerges as a new pharmacological target for retinal degeneration
Autophagy|2024
7 cit.
10
Fast and quantitative mitophagy assessment by flow cytometry using the mito-QC reporter
Frontiers in Cell and Developmental Biology|2024
7 cit.

Emerging Leaders

Drafting the new consensus

Researchers

1
Robert J. Glynn
Brigham and Women's Hospital
2
Xing Liu
Chinese Academy of Sciences
3
Daniel A. Bachovchin
Memorial Sloan Kettering Cancer Center
4
Yogendra Kanthi
National Heart Lung and Blood Institute
5
Andrea Ablasser
École Polytechnique Fédérale de Lausanne
6
Huabin He
Jiujiang First People's Hospital
7
Chengliang Zhu
Wuhan University
8
Jason D. Goldman
University of Washington
9
Zhaofang Bai
Fujian University of Traditional Chinese Medicine
10
Zhibo Liu
Beijing National Laboratory for Molecular Sciences

Papers

1
cGAS–STING drives ageing-related inflammation and neurodegeneration
Nature|2023
925 cit.
2
The cGAS–STING pathway drives type I IFN immunopathology in COVID-19
Nature|2022
542 cit.
3
Streptococcal pyrogenic exotoxin B cleaves GSDMA and triggers pyroptosis
Nature|2022
361 cit.
4
Clathrin-associated AP-1 controls termination of STING signalling
Nature|2022
149 cit.
5
Boron encapsulated in a liposome can be used for combinational neutron capture therapy
Nature Communications|2022
122 cit.
6
Association between systemic immune-inflammation index and chronic obstructive pulmonary disease: a population-based study
BMC Pulmonary Medicine|2023
116 cit.
7
Radiotherapy Reduces <i>N</i>-Oxides for Prodrug Activation in Tumors
Journal of the American Chemical Society|2022
104 cit.
8
Endothelial Cell–Activating Antibodies in COVID‐19
Arthritis & Rheumatology|2022
81 cit.
9
Localized nuclear reaction breaks boron drug capsules loaded with immune adjuvants for cancer immunotherapy
Nature Communications|2023
70 cit.
10
Radiotherapy activates picolinium prodrugs in tumours
Nature Chemistry|2024
70 cit.

Current Senior Leaders

Wrote the book, still writing it

Researchers

1
Feng Shao
Nantong University
2
Thirumala‐Devi Kanneganti
St. Jude Children's Research Hospital
3
Vishva M. Dixit
Molecular Oncology (United States)
4
Zhijian J. Chen
Howard Hughes Medical Institute
5
Eicke Latz
German Rheumatism Research Centre
6
Gabriel Núñez
Michigan Center for Translational Pathology
7
Richard A. Flavell
Yale University
8
Hao Wu
Yanbian University of Science and Technology
9
Emad S. Alnemri
Thomas Jefferson University
10
Daniel L. Kastner
National Institutes of Health

Papers

1
Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death
Nature|2015
6.5k cit.
2
Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3
Nature|2001
6.1k cit.
3
Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway
Science|2012
4.8k cit.
4
NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
Nature|2010
3.9k cit.
5
Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling
Nature|2015
3.7k cit.
6
Identification and Characterization of MAVS, a Mitochondrial Antiviral Signaling Protein that Activates NF-κB and IRF3
Cell|2005
3.3k cit.
7
Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin
Nature|2017
3.2k cit.
8
FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex
Cell|1996
3.1k cit.
9
Cryopyrin activates the inflammasome in response to toxins and ATP
Nature|2006
3k cit.
10
Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization
Nature Immunology|2008
3k cit.

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