Leaderboards/Genetics, Aging, and Longevity in Model Organisms

Genetics, Aging, and Longevity in Model Organisms

Last updated July 15, 2026

Rising Stars

Fresh ink, massive impact

Researchers

1
Philipp Schlegel
University of Cambridge
2
M. Austin Argentieri
Broad Institute
3
Tomas Schmauck‐Medina
University of Oslo
4
Liyang Song
Westlake University
5
Dayoon Kwon
University of California, Los Angeles
6
Cédric Debès
University of Cologne
7
Natalia Bobba‐Alves
Columbia University Irving Medical Center
8
Zakirullah Khan
Kyungpook National University
9
Aida Rodríguez‐Nuevo
Centre for Genomic Regulation
10
Kristen Browder
Pennsylvania State University

Papers

1
Whole-brain annotation and multi-connectome cell typing of Drosophila
Nature|2024
367 cit.
2
Proteomic aging clock predicts mortality and risk of common age-related diseases in diverse populations
Nature Medicine|2024
281 cit.
3
Integrating the environmental and genetic architectures of aging and mortality
Nature Medicine|2025
160 cit.
4
Exogenous melatonin induces salt and drought stress tolerance in rice by promoting plant growth and defense system
Scientific Reports|2024
127 cit.
5
Publication in Nature (2025) [84 citations, W4408613778]
Nature|2025
84 cit.
6
Diet and the gut microbiome in patients with Parkinson’s disease
npj Parkinson s Disease|2024
69 cit.
7
Exogenous GABA Enhances Copper Stress Resilience in Rice Plants via Antioxidant Defense Mechanisms, Gene Regulation, Mineral Uptake, and Copper Homeostasis
Antioxidants|2024
25 cit.
8
Mitigation of nickel toxicity in rice plants by exogenous γ-aminobutyric acid: Enhancement of growth, antioxidant defense, and metal homeostasis
Plant Stress|2025
12 cit.
9
Interaction Between Traffic-Related Air Pollution and Parkinson Disease Polygenic Risk Score
JAMA Network Open|2025
8 cit.
10
Of scents and cytokines: How olfactory and food aversions relate to nausea and immunomodulation in early pregnancy
Evolution Medicine and Public Health|2025
2 cit.

Emerging Leaders

Drafting the new consensus

Researchers

1
Lucas B. Harrington
Mammoth Biosciences (United States)
2
Jonathan S. Packer
Foresite (United States)
3
Darren A. Cusanovich
University of Arizona
4
Lijia Ma
Westlake University
5
Sebastian Will
Columbia University Irving Medical Center
6
Keir J. Menzies
University of Ottawa
7
Xuyuan Liu
Beijing Institute of Education
8
Chris Rinsch
Amazentis (Switzerland)
9
James A. Gagnon
University of Utah
10
Gregory M. Findlay
The Francis Crick Institute

Papers

1
Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults
Cell Reports Medicine|2022
217 cit.
2
Observation of Bose–Einstein condensation of dipolar molecules
Nature|2024
136 cit.
3
Collisionally stable gas of bosonic dipolar ground-state molecules
Nature Physics|2023
67 cit.
4
Ultracold Gas of Dipolar NaCs Ground State Molecules
Physical Review Letters|2023
65 cit.
5
Saturation genome editing maps the functional spectrum of pathogenic VHL alleles
Nature Genetics|2024
48 cit.
6
Deep sampling of gRNA in the human genome and deep-learning-informed prediction of gRNA activities
Cell Discovery|2023
32 cit.
7
High phase-space density gas of NaCs Feshbach molecules
Physical Review Research|2022
24 cit.
8
PEAC-seq adopts Prime Editor to detect CRISPR off-target and DNA translocation
Nature Communications|2022
24 cit.
9
Germ cell progression through zebrafish spermatogenesis declines with age
Development|2024
20 cit.
10
Extensive evaluation of ATAC-seq protocols for native or formaldehyde-fixed nuclei
BMC Genomics|2022
18 cit.

Current Senior Leaders

Wrote the book, still writing it

Researchers

1
Gary Ruvkun
Harvard University
2
H. Robert Horvitz
Moscow Institute of Thermal Technology
3
Craig C. Mello
University of Massachusetts Chan Medical School
4
Victor Ambros
University of Massachusetts Chan Medical School
5
Cynthia Kenyon
Buck Institute for Research on Aging
6
Cornelia I. Bargmann
Rockefeller University
7
Leonard Guarente
Lifespan
8
Paul W. Sternberg
California Institute of Technology
9
David Sinclair
Center for Human Genetics
10
Linda Partridge
MRC Unit for Lifelong Health and Ageing

Papers

1
Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
Nature|1998
15.3k cit.
2
The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
Cell|1993
12.8k cit.
3
The functions of animal microRNAs
Nature|2004
10.8k cit.
4
The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans
Nature|2000
5k cit.
5
Resveratrol improves health and survival of mice on a high-calorie diet
Nature|2006
4.2k cit.
6
Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans
Cell|1993
4.2k cit.
7
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
Nature|2003
3.8k cit.
8
Post-embryonic cell lineages of the nematode, Caenorhabditis elegans
Developmental Biology|1977
3.6k cit.
9
Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
Nature|2000
3.5k cit.
10
A C. elegans mutant that lives twice as long as wild type
Nature|1993
3.4k cit.

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