Leaderboards/Enzyme function and inhibition

Enzyme function and inhibition

Last updated July 15, 2026

Rising Stars

Fresh ink, massive impact

Researchers

1
Aida Buza
University of Prishtina
2
Blinera Zognjani
University of Prishtina
3
Saliha Gündoğdu
Sakarya University
4
Annachiara Sarnella
Institute of Biostructure and Bioimaging
5
Xuxian Su
Sun Yat-sen University
6
Salma M. Hefny
Tanta University
7
Michael Tapera
University of Wuppertal
8
Nebih Lolak
Adıyaman University
9
Anjali Rawat
Sir Ganga Ram Hospital
10
Mubashir Aziz
Islamia University of Bahawalpur

Papers

1
Publication in Bioorganic Chemistry (2025) [50 citations, W4411544902]
Bioorganic Chemistry|2025
50 cit.
2
Publication in RSC Medicinal Chemistry (2024) [48 citations, W4403130423]
RSC Medicinal Chemistry|2024
48 cit.
3
Novel 1,2,4-triazole-maleamic acid derivatives: synthesis and evaluation as anticancer agents with carbonic anhydrase inhibitory activity
Journal of Molecular Structure|2024
36 cit.
4
Publication in Pharmacology Research & Perspectives (2025) [13 citations, W4408845952]
Pharmacology Research & Perspectives|2025
13 cit.
5
Publication in Archives of Biochemistry and Biophysics (2024) [8 citations, W4403330219]
Archives of Biochemistry and Biophysics|2024
8 cit.
6
Imidazole-based hydrazones as potent anti-colon cancer agents: Design, synthesis, biological evaluation and computational studies
Journal of Molecular Structure|2024
6 cit.
7
Identification of dimethyl 2,2’-((methylenebis(2-(2H-benzo[d][1,2,3]triazol-2-yl)-4-(2,4,4-trimethylpentan-2-yl)-6,1phenylene))bis(oxy))diacetate (TAJ4) as antagonist of NEK-Family: a future for potential drug discovery
BMC Cancer|2024
4 cit.
8
Cytotoxic activity, caspase-3 mediated apoptosis, and PARP-1 inhibition targeted molecular modeling studies of novel imidazole-fused hydrazones
Journal of Molecular Liquids|2025
3 cit.
9
Publication in Anti-Cancer Agents in Medicinal Chemistry (2024) [2 citations, W4391879817]
Anti-Cancer Agents in Medicinal Chemistry|2024
2 cit.
10
Publication in Molecules (2024) [2 citations, W4401324138]
Molecules|2024
2 cit.

Emerging Leaders

Drafting the new consensus

Researchers

1
Alessio Nocentini
University of Florence
2
Szu Shen Wong
Keele University
3
Süleyman Akocak
Adıyaman University
4
Ümit M. Koçyiğit
Sivas Cumhuriyet Üniversitesi
5
Stephen Chia
Universitätsklinikum Erlangen
6
Murat Şentürk
Ağrı İbrahim Çeçen University
7
Haytham O. Tawfik
Tanta University
8
Chae Un Kim
Ulsan National Institute of Science and Technology
9
Fikret Türkan
University of Turku
10
Oztekin Algul
Erzincan Binali Yıldırım University

Papers

1
The Concise Guide to PHARMACOLOGY 2023/24: Enzymes
British Journal of Pharmacology|2023
439 cit.
2
Ligand-Based Design on the Dog-Bone-Shaped BIBR1532 Pharmacophoric Features and Synthesis of Novel Analogues as Promising Telomerase Inhibitors with In Vitro and In Vivo Evaluations
Journal of Medicinal Chemistry|2022
67 cit.
3
Discovery of new carbonic anhydrase IX inhibitors as anticancer agents by toning the hydrophobic and hydrophilic rims of the active site to encounter the dual-tail approach
European Journal of Medicinal Chemistry|2022
63 cit.
4
Discovery of sulfonamide-tethered isatin derivatives as novel anticancer agents and VEGFR-2 inhibitors
Journal of Enzyme Inhibition and Medicinal Chemistry|2023
47 cit.
5
Synthesis, characterization, and biological evaluation of some novel Schiff bases as potential metabolic enzyme inhibitors
Archiv der Pharmazie|2022
44 cit.
6
A new framework for novel analogues of pazopanib as potent and selective human carbonic anhydrase inhibitors: Design, repurposing rational, synthesis, crystallographic, in vivo and in vitro biological assessments
European Journal of Medicinal Chemistry|2024
43 cit.
7
Discovery and Mechanistic Studies of Dual-Target Hits for Carbonic Anhydrase IX and VEGFR-2 as Potential Agents for Solid Tumors: X-ray, <i>In Vitro</i>, <i>In Vivo</i>, and <i>In Silico</i> Investigations of Coumarin-Based Thiazoles
Journal of Medicinal Chemistry|2024
42 cit.
8
Determination of biological studies and molecular docking calculations of isatin-thiosemicarbazone hybrid compounds
Journal of Molecular Structure|2022
41 cit.
9
Lead Optimization of BIBR1591 To Improve Its Telomerase Inhibitory Activity: Design and Synthesis of Novel Four Chemical Series with In Silico, In Vitro, and In Vivo Preclinical Assessments
Journal of Medicinal Chemistry|2023
36 cit.
10
Novel 3-(6-methylpyridin-2-yl)coumarin-based chalcones as selective inhibitors of cancer-related carbonic anhydrases IX and XII endowed with anti-proliferative activity
Journal of Enzyme Inhibition and Medicinal Chemistry|2022
35 cit.

Current Senior Leaders

Wrote the book, still writing it

Researchers

1
Claudiu T. Supuran
University of Florence
2
İlhami Gülçın
Tokat Gaziosmanpaşa Üniversitesi
3
Robert McKenna
University of Florida
4
Clemente Capasso
Institute of Biosciences and Bioresources
5
Adrian L. Harris
University of Oxford
6
Şükrü Beydemir
Anadolu University
7
Israel Silman
Weizmann Institute of Science
8
Arthur Kornberg
Texas Tech University
9
Nathan O. Kaplan
Brandeis University
10
Shoukat Dedhar
Sunnybrook Health Science Centre

Papers

1
Atomic Structure of Acetylcholinesterase from <i>Torpedo californica</i> : A Prototypic Acetylcholine-Binding Protein
Science|1991
2.7k cit.
2
Antioxidant and radical scavenging properties of curcumin
Chemico-Biological Interactions|2008
1.9k cit.
3
Detection of elevated levels of tumour‐associated microRNAs in serum of patients with diffuse large B‐cell lymphoma
British Journal of Haematology|2008
1.7k cit.
4
Carbonic anhydrase inhibitors
Medicinal Research Reviews|2002
1.4k cit.
5
The Expression and Distribution of the Hypoxia-Inducible Factors HIF-1α and HIF-2α in Normal Human Tissues, Cancers, and Tumor-Associated Macrophages
American Journal Of Pathology|2000
1.3k cit.
6
Hypoxia-inducible expression of tumor-associated carbonic anhydrases.
PubMed|2000
1.3k cit.
7
Association of macrophage infiltration with angiogenesis and prognosis in invasive breast carcinoma.
PubMed|1996
1.2k cit.
8
Antioxidant activity of caffeic acid (3,4-dihydroxycinnamic acid)
Toxicology|2005
1.1k cit.
9
THE EXTINCTION COEFFICIENTS OF THE REDUCED BAND OF PYRIDINE NUCLEOTIDES
Journal of Biological Chemistry|1948
1.1k cit.
10
Regulation of cell adhesion and anchorage-dependent growth by a new β1-integrin-linked protein kinase
Nature|1996
1.1k cit.

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