Leaderboards/Endoplasmic Reticulum Stress and Disease

Endoplasmic Reticulum Stress and Disease

Last updated July 15, 2026

Rising Stars

Fresh ink, massive impact

Researchers

1
Yuxuan Li
Second Affiliated Hospital of Zhejiang University
2
Xiangyi Pu
Chinese Academy of Medical Sciences & Peking Union Medical College
3
Jing Jin
University of Science and Technology of China
4
Christina T. Stankey
Washington University in St. Louis
5
Shouya Feng
The University of Melbourne
6
Matthew D. Figley
Washington University in St. Louis
7
Qiaoxia Zheng
Institute of Biophysics
8
F.X. Reymond Sutandy
National Central University
9
Chengran Yang
Washington University in St. Louis
10
Sumit Sen Santara
Indian Institute of Science Education and Research Kolkata

Papers

1
Updated mechanisms of MASLD pathogenesis
Lipids in Health and Disease|2024
239 cit.
2
Publication in Nature (2024) [142 citations, W4399366020]
Nature|2024
142 cit.
3
Tanshinone IIA modulates Sirt5 and Metll3 interaction to govern mitochondria-endoplasmic reticulum unfolded protein response in coronary microvascular injury
Phytomedicine|2025
103 cit.
4
Ginsenoside Rb1 ameliorates heart failure through DUSP-1-TMBIM-6-mediated mitochondrial quality control and gut flora interactions
Phytomedicine|2024
75 cit.
5
Ginsenoside Rb1 attenuates coronary microvascular inflammatory injury via NDUFS4-SIRT5-DUSP1-mediated mitochondrial quality control in a murine ischemia-reperfusion model
Journal of Ginseng Research|2025
50 cit.
6
Ca2+/calmodulin-dependent protein kinase II β decodes ER Ca2+ transients to trigger autophagosome formation
Molecular Cell|2024
21 cit.
7
European and African ancestry-specific plasma protein-QTL and metabolite-QTL analyses identify ancestry-specific T2D effector proteins and metabolites
Nature Communications|2025
5 cit.
8
Upgrading delivery rooms in Africa’s primary healthcare systems: a combination strategy of the ‘staff, stuff, space, and systems’ framework and emerging technologies
Journal of Global Health|2025
3 cit.
9
iTr35 cells: a novel immunoregulatory subset involved in bone loss in rheumatoid arthritis and clinical implications
Annals of Medicine|2025
3 cit.
10
Publication in The Journal of Rheumatology (2025) [1 citation, W4410513271]
The Journal of Rheumatology|2025
1 cit.

Emerging Leaders

Drafting the new consensus

Researchers

1
Liliana Malinovska
ETH Zurich
2
Christian Münch
Goethe University Frankfurt
3
Abdou Rachid Thiam
Centre National de la Recherche Scientifique
4
Arne Moeller
Osnabrück University
5
Christoph J. Burckhardt
Southwestern Medical Center
6
Charlotte L. Scott
Ghent University
7
Thomas Ve
Griffith University
8
Seok‐Kyu Kwon
Korea Institute of Brain Science
9
Woo‐Jae Park
Chung-Ang University
10
Martin Graef
Cornell University

Papers

1
Spatial proteogenomics reveals distinct and evolutionarily conserved hepatic macrophage niches
Cell|2022
936 cit.
2
A cytosolic surveillance mechanism activates the mitochondrial UPR
Nature|2023
188 cit.
3
Structural basis of SARM1 activation, substrate recognition, and inhibition by small molecules
Molecular Cell|2022
142 cit.
4
Protein import motor complex reacts to mitochondrial misfolding by reducing protein import and activating mitophagy
Nature Communications|2022
85 cit.
5
Spatially restricted and ontogenically distinct hepatic macrophages are required for tissue repair
Immunity|2025
69 cit.
6
Cholesterol esters form supercooled lipid droplets whose nucleation is facilitated by triacylglycerols
Nature Communications|2023
68 cit.
7
Parallel phospholipid transfer by Vps13 and Atg2 determines autophagosome biogenesis dynamics
The Journal of Cell Biology|2023
44 cit.
8
LC3B is lipidated to large lipid droplets during prolonged starvation for noncanonical autophagy
Developmental Cell|2023
35 cit.
9
Structural characterization of macro domain–containing Thoeris antiphage defense systems
Science Advances|2024
27 cit.
10
Giant organelle vesicles to uncover intracellular membrane mechanics and plasticity
Nature Communications|2024
19 cit.

Current Senior Leaders

Wrote the book, still writing it

Researchers

1
David Ron
Institute for Medical Research
2
Randal J. Kaufman
Discovery Institute
3
Daniel J. Klionsky
University of Michigan
4
Yoshinori Ohsumi
Tokyo Institute of Technology
5
Peter Walter
Bay Institute
6
Scott D. Emr
Cornell University
7
Randy Schekman
Howard Hughes Medical Institute
8
Kazutoshi Mori
Kyoto University
9
Amy S. Lee
University of Southern California
10
Gökhan S. Hotamışlıgil
Harvard University

Papers

1
Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance
Science|1993
7.5k cit.
2
Autophagy fights disease through cellular self-digestion
Nature|2008
6.4k cit.
3
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
Autophagy|2016
6k cit.
4
XBP1 mRNA Is Induced by ATF6 and Spliced by IRE1 in Response to ER Stress to Produce a Highly Active Transcription Factor
Cell|2001
4.1k cit.
5
Guidelines for the use and interpretation of assays for monitoring autophagy
Autophagy|2012
4k cit.
6
Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes
Science|2004
3.8k cit.
7
Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance.
Journal of Clinical Investigation|1995
3.5k cit.
8
A central role for JNK in obesity and insulin resistance
Nature|2002
3.3k cit.
9
An Integrated Stress Response Regulates Amino Acid Metabolism and Resistance to Oxidative Stress
Molecular Cell|2003
3.3k cit.
10
Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase
Nature|1999
3.3k cit.

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