Leaderboards/Click Chemistry and Applications

Click Chemistry and Applications

Last updated July 15, 2026

Rising Stars

Fresh ink, massive impact

Researchers

1
Andrew T. McNutt
University of Pittsburgh
2
Marine Bugnon
SIB Swiss Institute of Bioinformatics
3
Anna Lauko
University of Washington
4
Justin Jurczyk
University of California, Berkeley
5
Samuel L. Scinto
University of Delaware
6
V. S. Kulkarni
MNR Dental College and Hospital
7
Thumpati Prasanth
Virginia Commonwealth University
8
Miljan Kuljanin
Harvard University
9
Fabio Henrique dos Santos Rodrigues
Universidade Estadual de Campinas (UNICAMP)
10
Youxin Fu
Nanjing University

Papers

1
SwissDock 2024: major enhancements for small-molecule docking with Attracting Cavities and AutoDock Vina
Nucleic Acids Research|2024
480 cit.
2
Publication in Science (2025) [178 citations, W4407434658]
Science|2025
178 cit.
3
GNINA 1.3: the next increment in molecular docking with deep learning
Journal of Cheminformatics|2025
105 cit.
4
Triplet‐Triplet Energy Transfer: A Simple Strategy for an Efficient Visible Light‐Induced Photoclick Reaction
Angewandte Chemie International Edition|2024
12 cit.
5
Mechanism Inversion in Visible Light-Induced Photoclick Reactions
Journal of the American Chemical Society|2025
6 cit.
6
Publication in Journal of the American Chemical Society (2026) [1 citation, W7133210218]
Journal of the American Chemical Society|2026
1 cit.
7
Open-ComBind: Harnessing unlabeled data for improved binding pose prediction
Biophysical Journal|2024
0 cit.
8
Publication in Angewandte Chemie (2024) [W4393055292]
Angewandte Chemie|2024
0 cit.
9
Publication in Chinese Chemical Letters (2025) [W4412909905]
Chinese Chemical Letters|2025
0 cit.
10
Publication in Figshare (2026) [W7133338935]
Figshare|2026
0 cit.

Emerging Leaders

Drafting the new consensus

Researchers

1
Jiajia Dong
Zhaotong University
2
Nir London
Weizmann Institute of Science
3
Rob Oslund
Arup Group (United States)
4
Jamal Saeh
AstraZeneca (Brazil)
5
Bahaa G. M. Youssif
Assiut University
6
Haoxing Wu
Sichuan University
7
Xiaoyu Yang
Shanghai University of Traditional Chinese Medicine
8
Xinyuan Fan
Peking University
9
Ku‐Lung Hsu
The University of Texas at Austin
10
James V. Oakley
Princeton University

Papers

1
Detection of cell–cell interactions via photocatalytic cell tagging
Nature Chemical Biology|2022
126 cit.
2
Radius measurement via super-resolution microscopy enables the development of a variable radii proximity labeling platform
Proceedings of the National Academy of Sciences|2022
118 cit.
3
Enantioselective Synthesis of Azahelicenes through Organocatalyzed Multicomponent Reactions
Angewandte Chemie International Edition|2023
80 cit.
4
Enantioselective Synthesis of Planar‐Chiral Macrocycles through Asymmetric Electrophilic Aromatic Amination
Angewandte Chemie International Edition|2022
76 cit.
5
Bioorthogonal photocatalytic proximity labeling in primary living samples
Nature Communications|2024
74 cit.
6
Catalytic Asymmetric Synthesis of Axially Chiral Diaryl Ethers through Enantioselective Desymmetrization
Angewandte Chemie International Edition|2023
73 cit.
7
Catalytic Enantioselective Synthesis of Inherently Chiral Molecules: Recent Advances
European Journal of Organic Chemistry|2023
66 cit.
8
Overcoming Spectral Dependence: A General Strategy for Developing Far‐Red and Near‐Infrared Ultra‐Fluorogenic Tetrazine Bioorthogonal Probes
Angewandte Chemie International Edition|2022
64 cit.
9
Optimization and SAR investigation of novel 2,3-dihydropyrazino[1,2-a]indole-1,4-dione derivatives as EGFR and BRAFV600E dual inhibitors with potent antiproliferative and antioxidant activities
Bioorganic Chemistry|2022
59 cit.
10
New 1,3,4‐oxadiazoles linked with the 1,2,3‐triazole moiety as antiproliferative agents targeting the EGFR tyrosine kinase
Archiv der Pharmazie|2022
55 cit.

Current Senior Leaders

Wrote the book, still writing it

Researchers

1
K. Barry Sharpless
Scripps Research Institute
2
Carolyn R. Bertozzi
Howard Hughes Medical Institute
3
Valery V. Fokin
Scripps Research Institute
4
Benjamin F. Cravatt
Scripps Institution of Oceanography
5
Arthur J. Olson
Scripps Research Institute
6
Stephen B. H. Kent
University of Illinois Chicago
7
Morten Meldal
University of Copenhagen
8
M. G. Finn
Georgia Institute of Technology
9
Craig J. Hawker
University of California System
10
Frank Wuest
University of Alberta

Papers

1
AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading
Journal of Computational Chemistry|2009
37.1k cit.
2
AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility
Journal of Computational Chemistry|2009
25k cit.
3
Click Chemistry: Diverse Chemical Function from a Few Good Reactions
Angewandte Chemie International Edition|2001
13k cit.
4
A Stepwise Huisgen Cycloaddition Process: Copper(I)-Catalyzed Regioselective “Ligation” of Azides and Terminal Alkynes
Angewandte Chemie International Edition|2002
11.5k cit.
5
Automated docking using a Lamarckian genetic algorithm and an empirical binding free energy function
Journal of Computational Chemistry|1998
10.8k cit.
6
Click Chemistry: Diverse Chemical Function from a Few Good Reactions
Angewandte Chemie International Edition|2001
9.3k cit.
7
Peptidotriazoles on Solid Phase:  [1,2,3]-Triazoles by Regiospecific Copper(I)-Catalyzed 1,3-Dipolar Cycloadditions of Terminal Alkynes to Azides
The Journal of Organic Chemistry|2002
8.5k cit.
8
In situ click chemistry generation of cyclooxygenase-2 inhibitors
Nature Communications|2017
7.6k cit.
9
Synthesis of Proteins by Native Chemical Ligation
Science|1994
4.1k cit.
10
Small-Molecule Library Screening by Docking with PyRx
Methods in molecular biology|2014
3.9k cit.

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