Leaderboards/Cancer-related gene regulation

Cancer-related gene regulation

Last updated July 15, 2026

Rising Stars

Fresh ink, massive impact

Researchers

1
Eliza Yankova
Wellcome/MRC Cambridge Stem Cell Institute
2
Netanel Loyfer
Hebrew University of Jerusalem
3
Jia Xiong
Zhejiang University
4
Shahin Ramazi
Tarbiat Modares University
5
Huilong Yin
Henan Medical University
6
Fanying Tang
AbbVie (United States)
7
Tomasz Chełmicki
Centre National de la Recherche Scientifique
8
Jonathan Welti
Institute of Cancer Research
9
Lihui Dong
Westlake University
10
Jiaqi Liu
Chinese Academy of Medical Sciences & Peking Union Medical College

Papers

1
Publication in Advanced Science (2025) [51 citations, W4407006010]
Advanced Science|2025
51 cit.
2
Inhibition of METTL3 in macrophages provides protection against intestinal inflammation
Cellular and Molecular Immunology|2024
24 cit.
3
Publication in The Journal of Nutritional Biochemistry (2024) [17 citations, W4401713364]
The Journal of Nutritional Biochemistry|2024
17 cit.
4
NXP800 Activates the Unfolded Protein Response, Altering AR and E2F Function to Impact Castration-Resistant Prostate Cancer Growth
Clinical Cancer Research|2025
8 cit.
5
Publication in Cancer Cell (2025) [5 citations, W4411058809]
Cancer Cell|2025
5 cit.
6
Publication in Animal Nutriomics (2024) [2 citations, W4405784311]
Animal Nutriomics|2024
2 cit.
7
<i>wgbstools</i> : a computational suite for DNA methylation sequencing data analysis
Life Science Alliance|2026
2 cit.
8
Abstract 6283: Performance evaluation of tumor microenvironment deconvolution and gene prediction methods in lung cancer
Cancer Research|2025
1 cit.
9
Abstract 1768: Pharmacological inhibition of METTL1 as a novel therapeutic strategy against aggressive malignancies
Cancer Research|2025
0 cit.
10
Publication in bioRxiv (Cold Spring Harbor Laboratory) (2026) [W7141366989]
bioRxiv (Cold Spring Harbor Laboratory)|2026
0 cit.

Emerging Leaders

Drafting the new consensus

Researchers

1
Erin Curley
Christiana Care Health System
2
Abed AlFatah Mansour
Salk Institute for Biological Studies
3
Yunsun Nam
The University of Texas Southwestern Medical Center
4
Shuibin Lin
Sun Yat-sen University
5
Konstantinos Tzelepis
Wellcome/MRC Cambridge Stem Cell Institute
6
Oliver Rausch
Mission Therapeutics (United Kingdom)
7
Dali Han
Beijing Institute of Genomics
8
Huiying Sun
Dalian Minzu University
9
Jianbo Diao
WuXi AppTec (China)
10
Jiwei Guo
Binzhou Medical University

Papers

1
N7-methylguanosine tRNA modification promotes esophageal squamous cell carcinoma tumorigenesis via the RPTOR/ULK1/autophagy axis
Nature Communications|2022
181 cit.
2
N6-methyladenosine (m6A) in 18S rRNA promotes fatty acid metabolism and oncogenic transformation
Nature Metabolism|2022
141 cit.
3
Structures and mechanisms of tRNA methylation by METTL1–WDR4
Nature|2023
122 cit.
4
Targeting tumour-intrinsic N <sup>7</sup> -methylguanosine tRNA modification inhibits MDSC recruitment and improves anti-PD-1 efficacy
Gut|2022
81 cit.
5
NAT10-mediated ac4C tRNA modification promotes EGFR mRNA translation and gefitinib resistance in cancer
Cell Reports|2023
73 cit.
6
METTL1/WDR4-mediated tRNA m7G modification and mRNA translation control promote oncogenesis and doxorubicin resistance
Oncogene|2023
48 cit.
7
N<sup>7</sup>-methylguanosine (m<sup>7</sup>G) tRNA modification: a novel autophagy modulator in cancer
Autophagy|2022
34 cit.
8
Pharmacological inhibition of METTL3 impacts specific haematopoietic lineages
Leukemia|2023
30 cit.
9
Treatment of acute myeloid leukemia models by targeting a cell surface RNA-binding protein
Nature Biotechnology|2025
20 cit.
10
Cellular Composition and 5hmC Signature Predict the Treatment Response of AML Patients to Azacitidine Combined with Chemotherapy
Advanced Science|2023
14 cit.

Current Senior Leaders

Wrote the book, still writing it

Researchers

1
Yi Zhang
Sun Yat-sen University
2
Chuan He
University of Chicago
3
C. David Allis
Rockefeller University
4
Hans Clevers
Hubrecht Institute for Developmental Biology and Stem Cell Research
5
Thomas Jenuwein
Max Planck Institute of Immunobiology and Epigenetics
6
Stephen B. Baylin
Johns Hopkins University
7
Danny Reinberg
Howard Hughes Medical Institute
8
Tony Kouzarides
The Gurdon Institute
9
Yang Shi
Wuhan University
10
Joan Massagué
Memorial Sloan Kettering Cancer Center

Papers

1
The language of covalent histone modifications
Nature|2000
8.6k cit.
2
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche
Nature|2009
7.2k cit.
3
Identification of stem cells in small intestine and colon by marker gene Lgr5
Nature|2007
5.7k cit.
4
N6-methyladenosine-dependent regulation of messenger RNA stability
Nature|2013
4.8k cit.
5
N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO
Nature Chemical Biology|2011
4.1k cit.
6
Histone Demethylation Mediated by the Nuclear Amine Oxidase Homolog LSD1
Cell|2004
4k cit.
7
Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium
Gastroenterology|2011
3.8k cit.
8
Role of Histone H3 Lysine 27 Methylation in Polycomb-Group Silencing
Science|2002
3.8k cit.
9
ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility
Molecular Cell|2012
3.7k cit.
10
N6-methyladenosine Modulates Messenger RNA Translation Efficiency
Cell|2015
3.6k cit.

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