Leaderboards/Bone Metabolism and Diseases

Bone Metabolism and Diseases

Last updated July 15, 2026

Rising Stars

Fresh ink, massive impact

Researchers

1
Leena Sapra
Mayo Clinic in Florida
2
Caifeng Deng
First Affiliated Hospital of Chengdu Medical College
3
Kwansung Seo
Kyung Hee University
4
Yongkuk Park
Brigham and Women's Hospital
5
An Lao
Fudan University
6
Renpeng Peng
Tongji Hospital
7
Neashan Mathavan
ETH Zurich
8
Pingcui Xu
Zhejiang Chinese Medical University
9
Hui Sophie Shu
Center for Excellence in Molecular Cell Science
10
James Rowe
MRC Cognition and Brain Sciences Unit

Papers

1
IL-17 promotes osteoclast-induced bone loss by regulating glutamine-dependent energy metabolism
Cell Death and Disease|2024
42 cit.
2
Frequency Spectrum Is More Effective for Multimodal Representation and Fusion: A Multimodal Spectrum Rumor Detector
Proceedings of the AAAI Conference on Artificial Intelligence|2024
39 cit.
3
<i>Bacillus coagulans</i> ameliorates inflammatory bone loss in post-menopausal osteoporosis via modulating the “Gut-Immune-Bone” axis
Gut Microbes|2025
30 cit.
4
Publication in Pharmacological Research (2024) [28 citations, W4392303169]
Pharmacological Research|2024
28 cit.
5
Sequential Targeting Chondroitin Sulfate‐Bilirubin Nanomedicine Attenuates Osteoarthritis via Reprogramming Lipid Metabolism in M1 Macrophages
Advanced Science|2025
23 cit.
6
Targeting the osteoclastogenic cytokine IL-9 as a novel immunotherapeutic strategy in mitigating inflammatory bone loss in post-menopausal osteoporosis
JBMR Plus|2024
18 cit.
7
Genetically engineered chondrocyte-mimetic nanoplatform attenuates osteoarthritis by blocking IL-1β and restoring sirtuin-3
Science Advances|2025
12 cit.
8
Compromised anti-osteoclastogenic and immunomodulatory functions of regulatory B cells (Bregs) aggravate inflammatory bone loss in post-menopausal osteoporosis
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease|2025
7 cit.
9
Sustained and enhanced inhibitory effects of allelochemicals on Microcystis Aeruginosa during its recruitment stage
The Science of The Total Environment|2024
6 cit.
10
Senescence-regulating agents remodel mesenchymal stem cell-schwann cell circuitry for diabetic bone regeneration
Biomaterials|2025
4 cit.

Emerging Leaders

Drafting the new consensus

Researchers

1
Xiao Chen
XinHua Hospital
2
Ingvar Jarle Vaage
Oslo University Hospital
3
Weiguo Zou
Center for Excellence in Molecular Cell Science
4
Ce Dou
Army Medical University
5
Jin Fan
Jiangsu Province Hospital
6
Hyung‐Mun Yun
Kyung Hee University
7
Zhengxiao Ouyang
Central South University
8
Jeroen J. J. P. van den Beucken
Radboud University Nijmegen
9
Xiaogang Wang
Third Affiliated Hospital of Southern Medical University
10
Xingang Cui
Second Military Medical University

Papers

1
Iron overload promotes intervertebral disc degeneration via inducing oxidative stress and ferroptosis in endplate chondrocytes
Free Radical Biology and Medicine|2022
159 cit.
2
Discovery and Application of Postnatal Nucleus Pulposus Progenitors Essential for Intervertebral Disc Homeostasis and Degeneration
Advanced Science|2022
83 cit.
3
TET enzymes regulate skeletal development through increasing chromatin accessibility of RUNX2 target genes
Nature Communications|2022
65 cit.
4
Icariin protects vertebral endplate chondrocytes against apoptosis and degeneration via activating Nrf-2/HO-1 pathway
Frontiers in Pharmacology|2022
56 cit.
5
The RNA-binding protein Musashi2 governs osteoblast-adipocyte lineage commitment by suppressing PPARγ signaling
Bone Research|2022
52 cit.
6
Astaxanthin suppresses oxidative stress and calcification in vertebral cartilage endplate via activating Nrf-2/HO-1 signaling pathway
International Immunopharmacology|2023
47 cit.
7
Sialylation of TLR2 initiates osteoclast fusion
Bone Research|2022
40 cit.
8
Osteoclast-derived apoptotic bodies inhibit naive CD8+ T cell activation via Siglec15, promoting breast cancer secondary metastasis
Cell Reports Medicine|2023
34 cit.
9
HIF-2α/TFR1 mediated iron homeostasis disruption aggravates cartilage endplate degeneration through ferroptotic damage and mtDNA release: A new mechanism of intervertebral disc degeneration
Journal of Orthopaedic Translation|2024
33 cit.
10
Activation of the Nrf-2 pathway by pinocembrin safeguards vertebral endplate chondrocytes against apoptosis and degeneration caused by oxidative stress
Life Sciences|2023
32 cit.

Current Senior Leaders

Wrote the book, still writing it

Researchers

1
Gérard Karsenty
Columbia University Irving Medical Center
2
Steven L. Teitelbaum
Washington University in St. Louis
3
Josef Penninger
Helmholtz Centre for Infection Research
4
Gregory R. Mundy
The University of Texas at San Antonio Health Science Center
5
Toshio Suda
Chinese Academy of Sciences
6
Stavros C. Manolagas
University of Arkansas for Medical Sciences
7
Claus Christiansen
VA Eastern Colorado Health Care System
8
Ernesto Canalis
UConn Health
9
Jane B. Lian
University of Vermont
10
Toshihisa Komori
Nagasaki University

Papers

1
Targeted Disruption of Results in a Complete Lack of Bone Formation owing to Maturational Arrest of Osteoblasts
Cell|1997
4.2k cit.
2
A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus–induced lung injury
Nature Medicine|2005
3.6k cit.
3
Denosumab for Prevention of Fractures in Postmenopausal Women with Osteoporosis
New England Journal of Medicine|2009
3.4k cit.
4
OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis
Nature|1999
3.4k cit.
5
Angiotensin-converting enzyme 2 protects from severe acute lung failure
Nature|2005
2.6k cit.
6
Endocrine Regulation of Energy Metabolism by the Skeleton
Cell|2007
2.5k cit.
7
Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2
Cell|2020
2.3k cit.
8
Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein
Nature|1997
2.1k cit.
9
Leptin Inhibits Bone Formation through a Hypothalamic Relay
Cell|2000
2.1k cit.
10
Tie2/Angiopoietin-1 Signaling Regulates Hematopoietic Stem Cell Quiescence in the Bone Marrow Niche
Cell|2004
1.9k cit.

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