Leaderboards/Biomarkers in Disease Mechanisms

Biomarkers in Disease Mechanisms

Last updated July 15, 2026

Rising Stars

Fresh ink, massive impact

Researchers

1
Lincoln Biswas
Nanyang Technological University
2
Leena Sapra
Mayo Clinic in Florida
3
Matteo Stravalaci
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
4
Laura Brylka
Universität Hamburg
5
Jiaming Bi
Southern Medical University
6
Anna Birnhuber
Medical University of Graz
7
Xuan-Ying Xin
Yanbian University of Science and Technology
8
Bhesh Raj Sharma
St. Jude Children's Research Hospital
9
Bo Yang
Sun Yat-sen University
10
Xiayao Diao
Chinese Academy of Medical Sciences & Peking Union Medical College

Papers

1
Cancer situation in China: an analysis based on the global epidemiological data released in 2024
Cancer Communications|2024
119 cit.
2
Publication in Bone Research (2024) [77 citations, W4392121888]
Bone Research|2024
77 cit.
3
Publication in The Journal of Immunology (2025) [32 citations, W4409585391]
The Journal of Immunology|2025
32 cit.
4
<i>Bacillus coagulans</i> ameliorates inflammatory bone loss in post-menopausal osteoporosis via modulating the “Gut-Immune-Bone” axis
Gut Microbes|2025
30 cit.
5
Publication in Proceedings of the National Academy of Sciences (2025) [26 citations, W4412111100]
Proceedings of the National Academy of Sciences|2025
26 cit.
6
Targeting the osteoclastogenic cytokine IL-9 as a novel immunotherapeutic strategy in mitigating inflammatory bone loss in post-menopausal osteoporosis
JBMR Plus|2024
18 cit.
7
Compromised anti-osteoclastogenic and immunomodulatory functions of regulatory B cells (Bregs) aggravate inflammatory bone loss in post-menopausal osteoporosis
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease|2025
7 cit.
8
Pulmonary vascular remodeling in Fra-2 transgenic mice is driven by type 2 inflammation and accompanied by pulmonary vascular hyperresponsiveness
American Journal of Physiology-Lung Cellular and Molecular Physiology|2025
3 cit.
9
Publication in Trends in Immunology (2025) [1 citation, W4407988214]
Trends in Immunology|2025
1 cit.
10
Publication (2024) [W4404098332]
Unknown Journal|2024
0 cit.

Emerging Leaders

Drafting the new consensus

Researchers

1
Thomas Clozel
Owl Research Institute
2
Junchao Duan
Third Way
3
Lingpeng Zhu
Wuxi People's Hospital
4
Yanjing Wang
Central South University
5
Taotao Ma
Guiyang Medical University
6
Chen Wang
Renji Hospital
7
Mohamed Lamkanfi
Ghent University Hospital
8
Jianyun Yan
Zhujiang Hospital
9
V. V. Skibitsky
Kuban State Medical University
10
Yanzhuo Zhao
Henan University Huaihe Hospital and Huaihe Clinical Institute

Papers

1
Repression of the antiporter SLC7A11/glutathione/glutathione peroxidase 4 axis drives ferroptosis of vascular smooth muscle cells to facilitate vascular calcification
Kidney International|2022
358 cit.
2
Silica nanoparticles induce pyroptosis and cardiac hypertrophy via ROS/NLRP3/Caspase-1 pathway
Free Radical Biology and Medicine|2022
139 cit.
3
Size-dependent toxicity of polystyrene microplastics on the gastrointestinal tract: Oxidative stress related-DNA damage and potential carcinogenicity
The Science of The Total Environment|2023
85 cit.
4
Sodium-glucose cotransporter 2 inhibitor canagliflozin alleviates vascular calcification through suppression of nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3 inflammasome
Cardiovascular Research|2023
65 cit.
5
Downregulation of <scp>HDAC9</scp> by the ketone metabolite β‐hydroxybutyrate suppresses vascular calcification
The Journal of Pathology|2022
59 cit.
6
Iron derived from NCOA4-mediated ferritinophagy causes cellular senescence via the cGAS-STING pathway
Cell Death Discovery|2023
56 cit.
7
Melatonin alleviates PM2.5-triggered macrophage M1 polarization and atherosclerosis via regulating NOX2-mediated oxidative stress homeostasis
Free Radical Biology and Medicine|2022
50 cit.
8
Enhanced safety prediction of vault settlement in urban tunnels using the pair-copula and Bayesian network
Applied Soft Computing|2022
45 cit.
9
New insight into air pollution-related cardiovascular disease: an adverse outcome pathway framework of PM2.5-associated vascular calcification
Cardiovascular Research|2024
44 cit.
10
PM2.5-induced iron homeostasis imbalance triggers cardiac hypertrophy through ferroptosis in a selective autophagy crosstalk manner
Redox Biology|2024
42 cit.

Current Senior Leaders

Wrote the book, still writing it

Researchers

1
Alberto Mantovani
Humanitas University
2
Luke O'neill
Trinity College Dublin
3
Matthew A. Cooper
Red de Investigación en Sida
4
Tomas Ganz
University of California, Los Angeles
5
Yehia Abed
University of Palestine
6
Cecília Garlanda
Humanitas University
7
Iichiro Shimomura
The University of Osaka
8
Riccardo Vigneri
Ospedale Garibaldi
9
Lee‐Ming Chuang
National Taiwan University
10
Andreas Pfeiffer
Helmholtz Zentrum München

Papers

1
Increased oxidative stress in obesity and its impact on metabolic syndrome
Journal of Clinical Investigation|2004
5.3k cit.
2
Succinate is an inflammatory signal that induces IL-1β through HIF-1α
Nature|2013
4k cit.
3
A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases
Nature Medicine|2015
2.8k cit.
4
Transcriptional Profiling of the Human Monocyte-to-Macrophage Differentiation and Polarization: New Molecules and Patterns of Gene Expression
The Journal of Immunology|2006
2.3k cit.
5
IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin
Journal of Clinical Investigation|2004
2.2k cit.
6
Hepcidin, a Urinary Antimicrobial Peptide Synthesized in the Liver
Journal of Biological Chemistry|2001
2.2k cit.
7
Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages
Cell|2016
2.2k cit.
8
IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin
Journal of Clinical Investigation|2004
2.1k cit.
9
Obesity and inflammation: the linking mechanism and the complications
Archives of Medical Science|2016
1.9k cit.
10
Visfatin: A Protein Secreted by Visceral Fat That Mimics the Effects of Insulin
Science|2004
1.9k cit.

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