Additional information 1. Additional information on generation of drug resistant cell lines. Additional information 2. Details of sample preparation and gene expression profiling. Additional information 3. Gene expression Data. Additional information 4. PCR primer sequences. Additional information 5. Additional details of analysis and quantification of sphingosine-1-phosphatefrom cell lines using high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). Additional information 6. Additional details of chemotherapy treatment of patients. Additional information 7. Pathways identified in Gene enrichment analysis (DAVID v6.7) of resistant cell lines. (PDF 725 kb)