James A. McCubrey, Linda S. Steelman, William H. Chappell et al.|Biochimica et Biophysica Acta (BBA) - Molecular Cell Research|2006
Cited by 2.3kOpen Access
Indiana University Health
Publishes on PI3K/AKT/mTOR signaling in cancer, Melanoma and MAPK Pathways, Cytokine Signaling Pathways and Interactions. 152 papers and 16.4k citations.
Add your photo, update your bio, and get notified when your ranking changes.
Dysregulated signaling through the Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways is often the result of genetic alterations in critical components in these pathways or upstream activators. Unrestricted cellular proliferation and decreased sensitivity to apoptotic-inducing agents are typically associated with activation of these pro-survival pathways. This review discusses the functions these pathways have in normal and neoplastic tissue growth and how they contribute to resistance to apoptotic stimuli. Crosstalk and commonly identified mutations that occur within these pathways that contribute to abnormal activation and cancer growth will also be addressed. Finally the recently described roles of these pathways in cancer stem cells, cellular senescence and aging will be evaluated. Controlling the expression of these pathways could ameliorate human health.