Cited by 1.5k
Island Health
Publishes on Prion Diseases and Protein Misfolding, Trace Elements in Health, Neurological diseases and metabolism. 73 papers and 10.8k citations.
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Purification of prions from scrapie-infected hamster brain yielded a protein that was not found in a similar fraction from uninfected brain. The protein migrated with an apparent molecular size of 27,000 to 30,000 daltons in sodium dodecyl sulfate polyacrylamide gels. The resistance of this protein to digestion by proteinase K distinguished it from proteins of similar molecular weight found in normal hamster brain. Initial results suggest that the amount of this protein correlates with the titer of the agent.